Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords
Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords作者机构:Institute of RF- & OE-ICs Southeast University Nanjing 210096 China Key Laboratory of Neural Regeneration of Jiangsu Province Nantong University Nantong 226001 China State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China
出 版 物:《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))
年 卷 期:2009年第19卷第10期
页 面:1261-1269页
核心收录:
学科分类:0831[工学-生物医学工程(可授工学、理学、医学学位)] 08[工学] 0805[工学-材料科学与工程(可授工学、理学学位)] 0836[工学-生物工程] 0702[理学-物理学]
基 金:supported by the National Natural Science Foundation of China (Grant Nos.69825101 30270391 30070255 and 90377013)
主 题:Nerve injury Microelectrode arrays Neural recordings Neurostimulation Functional recovery
摘 要:Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is *** microelectronic system has been realized in the forms of hybrid and integrated *** integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS *** animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic *** the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been ***,the feasibility of the presented method was demonstrated.