Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords

作     者：Zhigong Wanga,,Xiaosong Gub,Xiaoying Lü c,Zhenglin Jiangb,Wenyuan Li a,Guangming Lü b,Yufeng Wang a,Xiaoyan Shen a,Xintai Zhao a,Huiling Wangc,Zhenyu Zhang a,Hongmei Shen b,Yang Wua,Weixing Shen b,Jingyang Zhang a,Dong Chenc,Xiaoyi Maoa,Huaxiang Shenb a Institute of RF-& OE-ICs,Southeast University,Nanjing 210096,China b Key Laboratory of Neural Regeneration of Jiangsu Province,Nantong University,Nantong 226001,China c State Key Laboratory of Bioelectronics,Southeast University,Nanjing 210096,China 

作者机构：Institute of RF- & OE-ICs Southeast University Nanjing 210096 China Key Laboratory of Neural Regeneration of Jiangsu Province Nantong University Nantong 226001 China State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China 

出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))

年 卷 期：2009年第19卷第10期

页      面：1261-1269页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China (Grant Nos.69825101 30270391 30070255 and 90377013) 

主　　题：Nerve injury Microelectrode arrays Neural recordings Neurostimulation Functional recovery 

摘      要：Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is *** microelectronic system has been realized in the forms of hybrid and integrated *** integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS *** animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic *** the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been ***,the feasibility of the presented method was demonstrated.