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Endovascular treatment of a ruptured pseudoaneurysm of the internal carotid artery in a patient with nasopharyngeal cancer:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9121-9126页

作者： Jung-Soo Park Hyoung Gyu Jang Department of Neurosurgery Jeonbuk National University Medical School and HospitalJeonju 54907South Korea

BACKGROUND Radiation therapy(RT)for nasopharyngeal cancer can cause several *** rare cases,an internal carotid artery pseudoaneurysm can occur,which can be *** report the experience of a nasopharyngeal cancer patient who underwent radiation therapy and subsequently developed a fatal pseudoaneurysm of the petrous internal carotid *** SUMMARY A 39-year-old man was diagnosed with nasopharyngeal cancer 2 years ago(American Joint Committee on cancer Stage T3N2M0)and received concurrent chemoradiation *** subsequently relapsed and received *** week after the 4th cycle of chemotherapy,he was admitted to the emergency room of our hospital because of massive epistaxis accompanied by a headache.A pseudoaneurysm of the petrous internal carotid artery was confirmed by digital subtraction angiography(DSA).Stent-assisted endovascular coil embolization was performed and complete occlusion was *** pseudoaneurysm was observed on DSA after coil embolization;however,intermittent epistaxis was maintained even after coil *** seven days,a diagnostic laryngoscopy was *** bleeding occurred after aspiration of the blood clot during the laryngoscopy and the patient died of hypovolemic *** this case,epistaxis may have been a sign of pseudoaneurysm;therefore,treatment such as embolization should be performed promptly,and careful management should be undertaken after *** This case highlights a rare,serious complication of RT in nasopharyngeal cancer and how it should be recognized and treated.

关键词： Pseudoaneurysm nasopharyngeal cancer Radiation therapy Epistaxis Carotid artery pseudoaneurysm Case report

Emerging radiotherapy technologies and trends in nasopharyngeal cancer

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cancer Communications 2020年第9期40卷 395-405页

作者： Michelle Tseng Francis Ho Yiat Horng Leong Lea ChoungWong Ivan WK Tham Timothy Cheo Anne WM Lee Radiation Oncology Centre Mt Elizabeth Novena HospitalSingapore 329563Singapore Department of Clinical Oncology the University of Hong Kong-Shenzhen Hospitalthe University of Hong KongHong Kong 999077P.R.China

AbTechnology has always driven advances in radiotherapy *** this review,we describe the main technological advances in radiotherapy over the past decades for the treatment of nasopharyngeal cancer(NPC)and highlight some of the pressing issues and challenges that *** aim to identify emerging trends in radiation *** include advances in personalized medicine and advanced imaging modalities,standardization of planning and delineation,assessment of treatment response and adaptive re-planning,impact of particle therapy,and role of artificial intelligence or automation in clinical *** conclusion,we expect significant improvement in the therapeutic ratio of radiotherapy treatment for NPC over the next decade.

关键词： adaptive planning artificial intelligence nasopharyngeal cancer particle therapy personalized medicine radiotherapy

Prognosis and Survival of nasopharyngeal cancer in Cameroon

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第1期10卷 6-19页

作者： Jean Paul Engbang Amadou Njifou Therè se Daphné e Tjomb Maurice Mpessa Louis Richard Njock Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Douala Laquintinie hospital Douala Cameroon

Background: nasopharyngeal carcinoma (NPC) is an entity belonging to up-per aerodigestive tract cancers. NPC is more widespread in Southern China and South East Asia. In our country, it is the leading cause of head and neck cancers. Its prognosis remains bleak because of the late stage at diagnostic. Objectives: The objectives of this study were to determine the prognostic fac-tors and survival rate of patients with nasopharyngeal cancer in six reference hospitals in Cameroon. Material and Methods: It was a retrospective analytic study, conducted from January 2009 to December 2018. It was conducted in oncology, surgery and Ear Nose and Throat (ENT) units of six reference hos-pitals. Data from 114 files meeting the inclusion were collected. We have drawn survival curves and determined the different survival probabilities with the help of Kaplan-Meier Method. The different survival curves were compared using the Log-Rank Test (P Results: The mean age at the time of diagnosis of the 114 patients recruited was 45.30 ± 17.14 years. The predominant histological type was the UCNT (Undifferentiated Carcinoma of the NasoPharynx) representing 84.2%. According to the WHO classification, 2 patients were classified as stage I (1.8%), 33 as stage II (28.9%), 42 as stage III (36.8%), 25 as stage IV A (21.9%) and 12 as stage IV B (10.5%). At the end of the survival assessment period, 34 patients were dead and 73 patients (64%) were still alive. The median overall survival was 44 months. The overall survival rates at one, two, three, and four years were 80%;74%;68%;44%, respectively. The prognostic factors associated with poor survival were: late consultation time of more than 12

关键词： nasopharyngeal cancer Survival Prognostic Factors Detection Cameroon

Clinical outcomes for nasopharyngeal cancer with intracranial extension after taxanebased induction chemotherapy and concurrent chemo-radiotherapy in the modern era

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 25-33页

作者： Sarbani Ghosh-Laskar Avinash Pilar Carlton Johnny Kumar Prabhash Amit Joshi Jai Prakash Agarwal Tejpal Gupta Ashwini Budrukkar Vedang Murthy Monali Swain Vanita Noronha Vijay Maruthi Patil Prathamesh Pai Deepa Nair Devendra Arvind Chaukar Shivakumar Thiagarajan Gouri Pantvaidya Anuja Deshmukh Pankaj Chaturvedi Sudhir Nair Anil D’Cruz Department of Radiation Oncology Tato Memorial HospitalHomi Bhobho National InstituteMumbaiIndia Department of Medical Oncology Tata Memorial HospitalHomi Bhobha Notional InstituteMumbaiIndia Department of Surgical Oncolosy Tota Memorial HospitalHomi Bhabha Notional InstituteMumbait India

Objective:To evaluate the survival outcomes for a cohort of nasopharyngeal cancer with intracranial extension(ICE)treated with induction chemotherapy(ICT)followed by chemo-intensity-modulated radiotherapy(CTRT)at a tertiary cancer ***:We retrospectively analyzed 45 patients with histologically proven,non-metastatic NPC with ICE treated at our institute between October 2008 and October *** were classified as minor ICE or major ICE,based on the extent of *** the patients received 2-3 cycles of a taxane-based ICT regimen followed by *** was delivered with"riskadapted"intensity-modulated radiotherapy(IMRT)technique in all ***:After a median follow up of 45 months(range:8-113 months),the estimated 5-year DFS,LRFS,DMFS,and OS of the entire cohort was 58%,82%,67%and 74%*** multivariate analysis,histological subtype was an independent predictor of LRFS,and age was an independent predictor of *** extent of ICE showed only a trend towards worse DFS(P=0.06).None of the factors significantly predicted for DMFS or ***,N-stage,and response to ICT did not significantly affect any of the *** 2 or worse subcutaneous fibrosis was seen in 22%of patients and grade 2 or worse xerostomia was seen in 24%of patients at last follow ***-three percent of the patients developed clinical hypothyroidism at last follow *** of the patients experienced any neurological or vascular ***:Taxane-based induction chemotherapy followed by chemo-intensity modulated radiotherapy resulted in excellent locoregional control and survival with acceptable toxicities in patients of nasopharyngeal cancer with intracranial *** metastasis continues to be the predominant problem in these patients.

关键词： nasopharyngeal cancer Intracranial extension Clinical outcomes Induction chemotherapy and intensity-modulated radiotherapy

The Current Status of the Delineation and Determination of the Targets and the Radiation Protocols for nasopharyngeal cancer with Intensity-Modulated Radiotherapy

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Chinese Journal of Clinical Oncology 2007年第5期4卷 360-366页

作者： Suyu Zhu Bingqlang Hu Department of Radiation Oncology the Hunan Province Cancer Hospital Changsha 410013 China

IMRT has increased the local-regional control and decreased the complications from treating nasopharyngeal cancer （NPC）. Therefore studying IMRT is important. CT and MRI are complementary, and their joint use is currently considered to be the optimal modality to delineate the extent of the primary spread of NPC. The key problem in delineation of the neck nodes is how to translate anatomic node regions into the CT boundaries. The consensus guideline which narrowed the gap among different cancer centers is recommended in delineating the boundary of the cervical lymph node regions. The definition of the NPC GTV is clear and almost the same among the main cancer centers in their IMRT planning protocols. The suggested biological dose to the GTV is close to or more than 80 Gy; the main differences are the definitions of the CTVs and their schemes for the prescribed dose, and also the dosage to the high cervical region is different among those centers. According to their long-term follow-up results, it is suggested that, besides adding 5-10 mm margins to the primary lesions, the immediate high-risk structures （including the entire nasopharyngeal cavity, retropharyngeal space, clivus, base of the skull, pterygoid plates and muscles, parapharyngeal space, the sphenoid and partial ethmoid sinuses, the posterior third of the maxillary sinuses and the nasal cavity） should also be included with a prescription of more than 60 Gy, and the bilateral Ib, II and Va node levels should be ranked as high-risk regions and differentially prescribed for treatment with no less than 60 Gy.

关键词： nasopharyngeal cancer IMRT target delineation prescribed dose

A Single-cell Raman-based Platform for nasopharyngeal Carcinoma Cell Line Identification and cancer Discrimination

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A Single-cell Raman-based Platform for Nasopharyngeal Carcin...

Preclinical evaluation and pilot clinical study of [^(18)F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Dan Xiong Wei Wu Dayang Chen Xiang Ji Xiuming Zhang Medical Laboratory of the third affiliated hospital of Shenzhen university

nasopharyngeal carcinoma is a kind of head and neck cancer with a high degree of malignancy, which is easy to relapse and metastise. Traditional testing relying on immunofluorescence or fluorescent in situ hybridization were proved to be tedious and expensive. Accurate, quick, and intact diagnosis is important for improving the survival rate of those patients with nasopharyngeal carcinoma. A Ramanbased cell assay is a promising tool for evaluating cancer progress. because it can provide abundant varied compound fingerprints of cancer cells in comparison with normal cells, Herein, we developed an efficient and accurate method on a label-free and noninvasive single-cell Raman microspectroscopy(SCRM) platform, to distinguish NPC cell lines 5-8 F,6-10 B, SUNE1, CNE1,CNE2, C666-1, HK1 from nasopharyngeal normal cell line NPEC1-BMI1. NPC cancer cells and noncancer cells can be differentiated by analyzing their intrinsic phenotypic Raman spectra at a large scale(5337 cm-1 Raman spectra in total). The Raman spectra of glycogen, nucleic acids, and tyrosine in NPC cancer cells were significantly higher than those in non-cancer cells. However, the Raman spectra of lipids in NPC cancer cells were significantly lower than those in non-cancer cells. Those results are consistent with the high expressions of glycogen, nucleic acids, and tyrosine and low expression of lipid in NPC cancer cells. Support Vector Machine(SVM)analysis distinctly differentiates NPC cancer cells from non-cancer cells with 97.85% *** tissues were also clearly distinguished from control tissues with 93.95% ***, our study developed an efficient SCRM-based method to evaluate the cells canceration of nasal tissue in advance which shed light on established quick and accurate diagnose during surgery of nasopharyngeal carcinoma. As a complementary tool, the platform was expected to view the real-time dynamic cancerization status and contributed to improving the diagnosis and opera

关键词： nasopharyngeal cancer Raman spectroscopy Machine learning Biomarker

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Acta Pharmaceutica Sinica B 2022年第2期12卷 867-875页

作者： Kongzhen Hu Junqi Li Lijuan Wang Yong Huang Li Li Shimin Ye Yanjiang Han Shun Huang Hubing Wu Jin Su Ganghua Tang Department of Nuclear Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Shenzhen International Institute for Biomedical Research Shenzhen 518116China National cancer Center/National Clinical Research Center for cancer/cancer Hospital&Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510182China

In recent years,fibroblast activation protein(FAP)has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific ***,we aimed to design a novel^(18)Flabeled FAP tracer([^(18)F]Al F-P-FAPI)for FAP imaging and evaluated its potential for clinical ***[^(18)F]Al F-P-FAPI novel tracer was prepared in an automated manner within 42 min with a non-decay corrected radiochemical yield of 32±6%(n=8).Among A549-FAP cells,[^(18)F]Al F-P-FAPI demonstrated specific uptake,rapid internalization,and low cellular *** to the patent tracer[^(18)F]FAPI-42,[^(18)F]Al F-P-FAPI exhibited lower levels of cellular efflux in the A549-FAP cells and higher stability in ***-PET imaging in the A549-FAP tumor model indicated higher specific tumor uptake of[^(18)F]Al F-P-FAPI(7.0±1.0%ID/g)compared to patent tracers[^(18)F]FAPI-42(3.2±0.6%ID/g)and[68 Ga]Ga-FAPI-04(2.7±0.5%ID/g).Furthermore,in an initial diagnostic application in a patient with nasopharyngeal cancer,[^(18)F]Al F-P-FAPI and[^(18)F]FDG PET/CT showed comparable results for both primary tumors and lymph node *** results suggest that[^(18)F]Al F-P-FAPI can be conveniently prepared,with promising characteristics in the preclinical *** feasibility of FAP imaging was demonstrated using PET studies.

关键词： Fibroblast activation protein [^(18)F]AlF-P-FAPI PET nasopharyngeal cancer

Effect of WNT5A on epithelial-mesenchymal transition and its correlation with tumor invasion and metastasis in nasopharyngeal carcinoma

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Asian Pacific Journal of Tropical Medicine 2014年第6期7卷 488-491页

作者： Hong-Hai Zhu Xiao-Yuan Zhu Ming-Hui Zhou Gen-Yang Cheng Wei-Hua Lou Rhinology of the First Affiliated Hospital of Zhengzhou University Department of Otolaryngology-Head and Neck Surgery the First Affiliated Hospital of Zhengzhou University Department of Nephrology of the First Affiliated Hospital of Zhengzhou University

Objective:To investigate the correlation between nasopharyngeal carcinoma cell WNT5A and epithelial-mesenchytnal transition(emt)/metastasis,and investigate its possible ***:RT-PCR and gene transfection were used to detect the expression of nasopharyngeal carcinoma cell strains WNT5A and EMT related factor *** transfcction of NPC cell line 5-8F was determined by liposome of plasmid with WNT5A *** differential expressions of WNTSA and EMT-related factors in cells before and after transfection were detected by *** scratch assay and Transwell assay were used to detect the motility abilities of cells before and after 5-8F ***:The expressions of WNT5A and EMT related factors matrix metalloproleinasc-2 of the WNTSA transferred group in the nasopharyngeal carcinoma cell line 5-8F were higher than the blank control group and the empty vector transferred group,and the transfer ability of the WNTSA transferred group was higher than that in the blank control group and the empty vector transferred group,while the expressions of EMT related factors E-cadherin were lower than that in the blank control group and the empty vector transferred group,and the transfer ability of the WNT5A transferred group was higher than that in the blank control group and the empty vector transferred ***:In nasopharyngeal carcinoma cells,WNT5A can regulate the epithelial-mesenchymal transition and affect the ability of tumor invasion and metastasis of nasopharyngeal carcinoma.

关键词： WNT5A Epithelial-mesenchymal transition Matrix metalloproteinase-2 E-cadherin nasopharyngeal cancer Metastasis

Detection and analysis of anti-latent membrane protein 2A antibodies in the sera of patients with Epstein-Barr virus associated malignancies

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Chinese Medical Journal 2005年第9期118卷 725-730页

作者： CHENYun YAOKun SUNHua QINGJian PENGGuang-yong DepartmentofMicrobiologyandImmunology NanjingMedicalUniversityNanjing210029China CollegeofEnglish HehaiUniversityNanjing210098China CenterforCellandGeneTherapy BaylorCollegeofMedicineHoustonTexas77054USA

Background Epstein-Barr virus (EBV) associated malignancies with a Type Ⅱ latency gene expression pattern, such as Hodgkin’s disease, and nasopharyngeal carcinoma (NPC), frequently express the EBV antigen latent membrane protein 2A (LMP2A). We expected to establish a highly expressing LMP2A yeast cell strain and get the high quality LMP2A protein, which was used for detection, analysis and characterization of its antibodies in various patients’ sera of EBV associated *** The plasmid pPICZαA-LMP2A containing the full length of LMP2A cDNA was constructed and transformed to Pichia pastoris GS115 to express LMP2A protein. After fermentation and purification, the LMP2A protein was used as an antigen to detect anti-LMP2A antibodies (Abs) in the sera of patients with EBV-associated malignancies in enzyme linked immunosorbent assay (ELISA) or *** LMP2A was expressed successfully with an expected molecular weight of approximately 54 kD and Abs to LMP2A were strikingly specific to NPC. Two-thirds or more sera from NPC patients were positive for anti-LMP2A immunoglobulin G (IgG) Abs. The antibodies were absent from the sera of other EBV-associated diseases except a small fraction of the gastric carcinoma. Comparing anti-viral capsid Ags (VCA) IgA and LMP2A IgA titers in the sera from 76 NPC patients, only 55% were positive for anti-LMP2A IgA Abs while 70% were positive for anti-VCA IgA. However, we found that 3 sera negative for VCA IgA were positive for LMP2A *** The results suggested the potential significance of LMP2A specific Abs for the diagnosis of EBV-associated malignancies, especially NPC.

关键词： latent membrane 2 pastoris nasopharyngeal cancer malignancies