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nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

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Nano-Micro Letters 2021年第10期13卷 29-76页

作者： Xu Li Bingyang Dai Jiaxin Guo Lizhen Zheng Quanyi Guo Jiang Peng Jiankun Xu Ling Qin Musculoskeletal Research Laboratory Department of Orthopedics and TraumatologyThe Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China Joint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials The Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLAInstitute of OrthopedicsChinese PLA General HospitalBeijingPeople’s Republic of China Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China

Osteoarthritis is the most prevalent chronic and debilitating joint disease,resulting in huge medical and socioeconomic ***-articular administration of agents is clinically used for pain ***,the effectiveness is inapparent caused by the rapid clearance of *** overcome this issue,nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic *** the therapeutic programs are inseparable from pathological progress of osteoarthritis,an ideal delivery system should allow the release of therapeutic agents upon specific features of *** this review,we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug ***,we review the interactions of nanoparticles with cartilage microenvironment and the rational ***,we highlight advances in the therapeutic schemes according to the pathology ***,armed with an updated understanding of the pathological mechanisms,we place an emphasis on the development of“smart”bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological *** anticipate that the exploration of nanoparticles by balancing the efficacy,safety,and complexity will lay down a solid foundation tangible for clinical translation.

关键词： nanoparticle Drug delivery Osteoarthritis Articular cartilage Nanomedicine

nanoparticle-reinforced foam system for enhanced oil recovery(EOR):Mechanistic review and perspective

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Petroleum Science 2023年第4期20卷 2282-2304页

作者： Xue-Chen Tang Yi-Qiang Li Zhe-Yu Liu Ning Zhang National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249PR China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249PR China Tianjin Branch of China National Offshore Oil Corporation Limited Tianjin300459PR China

Boosted by economic development and rising living standards,the world's carbon dioxide emissions remain *** temperature rises below 1.5℃ by the end of the century requires rapid global carbon capture and storage *** successful application of carbon capture,utilization,and storage(CCUS)technology in oilfields has become the key to getting rid of this *** flooding,as an organic combination of gas and chemical flooding,became popular in the *** the irreplaceable advantages,as a thermodynamically unstable system,foam's stability has long restricted its development in enhanced oil and gas *** special surface/interface effects and small-size effects,nanoparticles can be used as foam stabilizers to enhance foam stability,thereby improving foam seepage and oil displacement effects in porous *** this paper,the decay kinetics and the stabilization mechanisms of nanoparticle-reinforced foams were systematically *** effects of nanoparticle characteristics,including particle concentration,surface wettability,particle size,and type,and reservoir environment factors,including oil,temperature,pressure,and salinity on the foam stabilization ability were analyzed in *** seepage and flooding mechanisms of nanoparticle-reinforced foams were summarized as:improving the plugging properties of foams,enhancing the interaction between foams and crude oil,and synergistically adjusting the wettability of reservoir ***,the challenges in the practical application of nanoparticle-reinforced foams were highlighted,and the development direction was *** development of nanoparticle-reinforced foam can open the way toward adaptive and evolutive EOR technology,taking one further step towards the high-efficiency production of the petroleum industry.

关键词： nanoparticle Foam stability Porous media Oil displacement mechanism Enhanced oil recovery

Effect of nanoparticle(Pd, Pd/Pt, Ni) deposition on high temperature hydrogenation of Ti-V alloys in gaseous flow containing CO

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Progress in Natural Science:Materials International 2017年第1期27卷 93-98页

作者： S.Suwarno M.Williams J.K.Solberg V.A.Yartys Department of Mechanical Engineering Institut Teknologi Sepuluh Nopember Department of Materials Science and Engineering NTNU Institute for Energy Technology University of the Western Cape

The hydrogenation properties of Ti-V hydrides coated with nanoparticles have been studied in gaseous mixtures of argon and hydrogen with and without additions of 1% CO. nanoparticles of Pd, Ni, and co-deposited Pd/Pt with particle sizes of;0–60 nm were formed by electroless deposition on the hydride surfaces. The alloy resistance to CO could be significantly improved by particle deposition. Large amounts of hydrogen were absorbed in a CO-containing gas when Ni and Pd/Pt deposition had been applied, while pure Pd deposition had no positive effect. Ni was found to have a stronger effect than those of Pd/Pt and Pd, possibly because of the size effect of Ni nanoparticles.

关键词： Metal hydride Titanium Vanadium nanoparticle Palladium Nickel Platinum Carbon monoxide

nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by a-cyclodextrin

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Chinese Chemical Letters 2019年第1期30卷 163-166页

作者： Lei Huang Jiaojiao Chen Muye He Xinyu Hou Yiben Lu Kaiyan Lou Feng Gao Department of Pharmaceutics School of Pharmacy East China University of Science and Technology Shanghai Key Laboratory of New Drug Design East China University of Science and Technology Shanghai Key Laboratory of Functional Materials Chemistry East China University of Science and Technology

This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of different amount of cyclodextrin(α-CD). The effect of α-CD inclusion to the self-assembly behavior of methoxy polyethylene glycol(mPEG) grafted chitosan(CS) was studied. The results showed that the mPEG grafted chitosan(mPEG-g-CS) forms self-assembled nanoparticles with either micelle or hollow sphere morphology depending on the ratio of α-CD to mPEG, as characterized by atomic force microscopy(AFM), transmission electron microscopy(TEM), and X-ray diffraction(XRD). Their sizes and zeta potential increased from 257.6 nmto 768.2 nm and from +4.5 mV to +11.6 mV, respectively, with the increasing amount of α-CD. The correlation between zeta potential and particle size of α-CD/mPEG-g-CS nanoparticles indicated varied PEG density on surface of nanoparticles. Based on the above experimental observations, a likely mechanism for the morphological transition of the rod-coil graft copolymer mPEG-g-CS was proposed.

关键词： a-Cyclodextrin mPEG Grafted chitosan Self-assembly nanoparticle Drug delivery

nanoparticle-based lift-off technique for ultra-thin nanoporous film preparation

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Science in China(Series F) 2008年第6期51卷 819-824页

作者： WANG Wei ZHAO Yu LEI YinHua LI ZhiHong National Key Laboratory of Nano/Micro Fabrication Technology Institute of Microelectronics Peking Uni-versity Beijing 100871 China

Ultra-thin membrane with nanoscale through hole has great potential in biomedical applications, where precise controllability of porosity, pore size and film thickness is urgently required. The present work proposed a cost-effective way to prepare the ultra-thin nanoporous film with a promising controllability. Monodispersed nanoparticle, rather than photoresist, is used as the sacrificial material for this new lift-off process. By releasing the particles, holes can be achieved with predeter-mined characters. A 110 nm-thick nanoporous aluminum film with well-controlled pore＇s diameter was successfully fabricated to validate the technique. The technique has wider process window and better applicability than other nanofabrication methods.

关键词： nanoparticle lift-off nanoporous film

NUMERICAL SIMULATION OF nanoparticle COAGULATION IN A POISEUILLE FLOW VIA A MOMENT METHOD

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Journal of Hydrodynamics 2008年第1期20卷 1-9页

作者： LIU Song LIN Jian-zhong State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China China Jiiiang University Hangzhou 310018 China

Numerical simulations of coagulating nano-scale aerosols in a two dimensional Poiseuille flow between fixed plates are performed. Evolution of the particle field is obtained by utilizing a moment method to approximate the aerosol general dynamic equation. A moment method is used, which assumes a lognormal function for the particle size distribution and requires knowledge of the first three moments. A Damk？hler number is defined to represent the ratio of the convection time scale to the coagulation time scale. Simulations are performed based on three Reynolds numbers, 100, 500 and 1000, and on three initial particle volume fractions corresponding to Damk？hler numbers 0.1, 0.2 and 1.0. Spatio-temporal evolution of the first three moments along with the geometric mean volume and standard deviation are discussed.

关键词： nanoparticle Coagulation moment method Poiseuille flow

nanoparticle drug delivery system for the treatment of brain tumors:Breaching the blood–brain barrier

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2786-2789页

作者： Qiyu Tang Guo Zhao Hong Fang Yale Jiang Peiwen Ma Jiawei Zhoua Dongyan Liu Shujun Xing Gaoquan Li Nian Liu Huiyu Chen Shuhang Wang Ning Li Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Chongqing Upgra Biotechnology Co. Ltd.Chongqing 401331China

To the Editor:Malignant brain tumors represent a substantial morbidity and mortality burden globally,with 308,102 new cases and 251,329 cancer-related deaths in *** tumors encompass primary tumors originating in the brain and brain metastases(BM)that have been spread from cancer lesions of other ***,BM are the most prevalent intracranial malignant tumor affecting approximately 20%-40%of cancer patients2.

关键词： nanoparticle Drug delivery system Blood-brain barrier Tumor Glioma

Solvent-free microwave-assisted synthesis of tenorite nanoparticle-decorated multi-walled carbon nanotubes

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Journal of Materials Science & Technology 2019年第6期35卷 1121-1127页

作者： Jennifer A. Rudd Cathren E. Gowenlock Virginia Gomez Ewa Kazimierska Abdullah M. Al-Enizi Enrico Andreoli Andrew R. Barron Energy Safety Research Institute Swansea University Bay Campus Swansea SA1 8EN UK Chemistry Department College of Sciences KingSaud University Riyadh Saudi Arabia Department of Chemistry Rice University Houston Texas 77005 USA Department of Materials Science and Nanoengineering Rice University Houston Texas 77005 USA

Copper-decorated carbon nanotubes(CNTs) have important applications as precursors for ultraconductive copper wires. Tenorite-decorated CNTs(CuO-CNTs) are ideal candidates and are currently developed using laborious processes. For this reason, we have developed a facile and scalable method for the synthesis of CuO-CNTs from copper acetate. It was found that the optimal loading of copper acetate onto the CNTs was 23.1 wt% and that three 1-minute microwave treatments were sufficient for the decomposition of copper acetate to copper oxide. The loading of copper oxide onto the nanotubes was confirmed using X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy and thermogravimetric analysis. The materials were characterised using X-ray diffraction and scanning electron microscopy.

关键词： Microwave-assisted synthesis Multi-walled carbon nanotubes Tenorite nanoparticle

Preparation and crystallization control of nanoparticle hydroxyapatlte

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Journal of University of Science and Technology Beijing 2004年第5期11卷 449-454页

作者： LianfengGuo WenguangZhang ChengtaoWang SchoolofMechanicalandPowerEngineering ShanghaiJiaotongUniversityShanghai200030China

nanoparticle hydroxyapatite was prepared by a wet chemical precipitationmethod. The effects of different synthesis conditions, i.e. contents of reagents (0.2, 0.5 and 0.8mol/L), reaction temperatures (20, 37, 55 and 75 deg C) and reaction time (0-24 h), were studiedbased on crystallization process analysis and the effects of washing methods (with water or alcohol)were also studied. Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD),transmission electron microscopy (TEM), electron diffraction (ED) and inductively coupled plasmaspectroscopy (ICP) were used to characterize the powders. Chemical analysis shows that the purity ofthe precipitated hydroxyapatite largely depends on reaction time. X-ray diffraction and TEMmicrographs results show that reaction temperature is a key factor affecting crystallinity,morphology and particle size. Degree of supersaturation and stirring also affects thecrystallization. Particles are in a shape of short rod and have a size of 20-40 nm in length at 20deg C and 37 deg C, but acicular morphology and a size of 150-170 nm in length at 75 deg *** are monocrystalline at 20 deg C and 37 deg C, and are poly-crystalline at 55 deg C and 75deg C. The results show that stoichiometry hydroxyapatite with controlled particle size, morphologyand crystallinity can be obtained by carefully controlling the reaction conditions.

关键词： precipitation hydroxyapatite crystallization nanoparticle biomaterial