检索结果-南通市图书馆

A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo

Nano Research 2019年第12期12卷 3024-3030页

作者： Jin Sil Lee Youngmin Hwang Hyeryeon Oh Sunghyun Kim Jin-Hwa Kim Jeung-Hoon Lee Yong Chui Shin Giyoong Tae Won II Choi Center for Convergence Bioceramic Materials Convergence R&D DivisionKorea Institute of Ceramic Engineering and Technology202Osongsaengmyeong l-rof Osong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology123 Cheomdan-gwagiroBuk-guGwangju 61005Republic of Korea SKINMED Co. Ltd.Daejeon 34028Republic of Korea Amicogen Inc.64 Dongburo 1259JinsungJinju 52621Republic of Korea

Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in *** n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair ***,the effect of topical application of CsA is limited by its poor water *** deliverysystems developed to enhance its solubility still showed poor skin *** overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of *** chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kDa enhanced the skin permeation of CsA through humancadaver skin in *** administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in *** results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs.

关键词： chitosan nanocapsule cyclosporin A transdermal delivery hair growth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Properties of Aroma Sustained-release Cotton Fabric with Rose Fragrance nanocapsule

引用

Chinese Journal of Chemical Engineering 2011年第3期19卷 523-528页

作者：胡静肖作兵周如隽马双双王明熙李臻 School of Perfume and Aroma Technology Shanghai Institute of Technology School of Biological Engineering East China University of Science and Technology

The aroma sustained-release cotton fabric was prepared by finishing rose fragrance nanocapsules directly on *** structure and properties of nanocapsules were demonstrated by transmission electron microscope(TEM),dynamic light scattering(DLS),fourier transform infrared spectrometer(FTIR),X-ray diffraction (XRD),gas chromatography-mass spectrometry(GC-MS)and electronic *** results showed that the spherical nanocapsule dispersed evenly and the average diameter kept 51.4 *** existence of COO peak(1741 cm? 1)in the FTIR curve of the finished cotton fabric and the decrease of crystallinity demonstrated that rose fragrance nanocapsules have been incorporated into the cotton *** washing resistance of the cotton fabrics finished by 51.4 nm nanocapsules was much better than that by rose fragrance ***,the loss of fragrance from the cotton fabrics finished by 51.4 nm nanocapsules was obviously lower than that by 532 nm nanocapsules and rose *** smaller the nanocapsule size,the better the sustained release *** nose analysis also displayed that the aroma released from the cotton fabrics finished by nanocapsules after washing has no obvious variety in contrast to that without *** cotton fabrics finished by nanocapsules has the excellent sustained release property.

关键词： aroma cotton fabric sustained-release nanocapsule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interface evolution in the platelet-like SiC@C and SiC@ SiO2 monocrystal nanocapsules

引用

Nano Research 2017年第8期10卷 2644-2656页

作者： Jian Gao Jieyi Yu Lei Zhou Javid Muhammad Xinglong Dong Yinong Wang Hongtao Yu Xie Quan Shaojie Li Youngguan Jung Key Laboratory of Materials Modification by Laser Ion and Electron Beams (Ministry of Education) School of Materials Science and Engineering Dalian University of Technology Dalian 115023 China Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education) School of Environmental Science and Technology Dalian University of Technology Dalian 116024 China InstrumentalAnalysis and Research Center Dalian University of Technology Panjin 124221 China Department of Mechanical Engineering Kumoh National Institute of Technology Daeharkro 53 Gumi Gyeong-Buk 730-701 Republic of Korea

Carbon-coated SiC@C nanocapsules （NCs） with a hexagonal platelet-like morphology were fabricated by a simple direct current （DC） arc-discharge plasma method. The SiC@C NCs were monocrystalline, 120-150 nm in size, and approximately 50 nm thick. The formation of the as-prepared SiC@C NCs included nucleation of truncated octahedral SiC seeds and subsequent anisotropic growth of the seeds into hexagonal nanoplatelets in a carbon-rich atmosphere. The disordered carbon layers on the SiC@C NCs were converted into SiO2 shells of SiC@SiO2 NCs by heat treatment at 650 ℃ in air, during which the shape and inherent characteristics of the crystalline SiC core were obtained. The interface evolution from carbon to SiO2 shells endowed the SiC@SiO2 NCs with enhanced photocatalytic activity due to the hydrophilic and transparent nature of the SiO2 shell, as well as to the photosensitive SiC nanocrystals. The band gap of the nanostructured SiC core was determined to be 2.70 eV. The SiC@SiO2 NCs degraded approximately 95% of methylene blue in 160 min under visible light irradiation.

关键词： silicon carbide silicon oxide nanocapsule monocrystal photocatalyst

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

引用

Nano Research 2017年第4期10卷 1393-1402页

作者： Jin Di Jicheng Yu Qun Wang Shanshan Yao Yanqi Ye Matthew Pless Yong Zhu Yun Jing Zhen Gu Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University Raleigh NC27695 USA Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA Department of Chemical and Biological Engineering Iowa State University Ames IA 50011 USA Department of Mechanical and Aerospace Engineering North Carolina State University Raleigh NC 27695 USA Department of Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Diabetes is a serious public health problem affecting 422 million people worldwide. Traditional diabetes management often requires multiple daily insulin injections, associated with pain and inadequate glycemia control. Herein, we have developed an ultrasound-triggered insulin delivery system capable of pulsatile insulin release that can provide both long-term sustained and fast on-demand responses. In this system, insulin-loaded poly（lactic-co-glycolic acid）（PLGA） nanocapsules are encapsulated within chitosan microgels. The encapsulated insulin in nanocapsules can passively diffuse from the nanoparticle but remain restricted within the microgel. Upon ultrasound treatment, the stored insulin in microgels can be rapidly released to regulate blood glucose levels. In a chemically-induced type I diabetic mouse model, we demonstrated that this system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner.

关键词： controlled drug delivery focused ultrasound diabetes nanocapsule microgel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preparation of pH-Responsive Doxorubicin nanocapsules by Combining High-gravity Antisolvent Precipitation with In-situ Polymerization for Intracellular Anticancer Drug Delivery

引用

Chemical Research in Chinese Universities 2020年第5期36卷 927-933页

作者： LIU Jie CHEN Bo ZHANG Jianjun College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029P.R.China State Key Laboratory of NBC Protection far Civilian Beijing 102205P.R.China

Owing to the low pH value in tumor and cancer cells,drug delivery systems based on pH-responsive polymer nanocarriers have been extensively explored for anticancer ***,we developed a pH-responsive doxonibicin(EXDX)nanocapsule(named as Dnanocapsule)prepared by combining in-situ polymerization teclinique with high-gravity antisolvent precipitation technique throngh an amphiphilic polymerized surface *** show an obvious spherical core-shell structure with a single DOX nanoparticle encapsulated in the polymer *** rate studies prove that the Dnanocapsules have robust dnig-release profiles under acidic environments due to the division of the pH-sensitive cross-linker,which triggers thecollapse of the polymer *** in vitro investigations demonstrated that the Dnanocapsules exhibited higli cellular uptake efficiency and cytotoxicity for both HeLa and MCF-7 cancer ***,this work may provide a promising strategy to design and develop various stimuli-responsive drug nanocapsules tor the treatment of cancer or other diseases.

关键词： pH-Responsive nanocapsule In-situ polymerization High-gravity anti solvent precipitation Anticancer cheniotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Boosting of the enhanced permeability and retention effect with nanocapsules improves the therapeutic effects of cetuximab

引用

Cancer Biology & Medicine 2020年第2期17卷 433-443页

作者： Chao Yang Yanli Tan Hongzhao Qi Junhu Zhou Lixia Long Qi Zhan Yunfei Wang Xubo Yuan Chunsheng Kang Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China Tianjin Neurological Institute Key Laboratory of Post-neurotrauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjin 300052China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 071000China Department of Pathology Hebei University Medical CollegeBaoding 071000China Tianjin Key Laboratory of Composite and Functional Materials School of Material Science and EngineeringTianjin UniversityTianjin 300072China institute for Translational Medicine Qingdao UniversityQingdao 266021China Affiliated Cancer Hospital 8l Institute of Guangzhou Medical University Guangzhou 510095China

Objective:The introduction of therapeutic antibodies(tAbs)into clinical practice has revolutionized tumor treatment strategies,but their tumor therapy efficiency is still far below expectations because of the rapid degradation and limited tumor accumulation of ***:We developed a nanocapsule-based delivery system to induce the self-augmentation of the enhanced permeability and retention(EPR)*** system constantly penetrated across the blood-tumor barrier into the tumor while avoiding the attack of tAbs by the immune *** biodistribution and therapeutic effect were tested with single dose administration of nanocapsule-tAbs in ***:The accumulation of Nano(cetuximab)within subcutaneous PC9 tumors was gradually enhanced over 6 days after single dose administration,which was contrary to the biodistribution of native ***(cetuximab)accumulated in tumor tissues via the EPR effect and released *** released cetuximab acted on vascular endothelial cells to destroy the blood-tumor barrier and induce self-augmentation of the EPR effect,which in turn contributed to further tumor accumulation of long-circulating Nano(cetuximab).Compared with single dose administration of native cetuximab,Nano(cetuximab)showed an effective tumor suppressive effect for 3 ***:The nanocapsule-based delivery system efficiently delivered tAbs to tum or tissues and released them to boost the EPR effect,which facilitated further tumor accumulation of the *** novel self-augmentation of the EPR effect facilitated by the biological characteristics of tAbs and nanotechnology contributed to the improvement of the therapeutic effect of tAbs,and stimulated new ideas for antibody-based tumor therapy.

关键词： Endothelial cells EPR effect nanocapsule single dose administration therapeutic antibody

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolution in the formation of graphene nanocapsules from coal tar pitch

引用

International Journal of Coal Science & Technology 2020年第4期7卷 816-824页

作者： D.M.Puente-Siller A.E.Garcia-Castillo J.A.Lopez-Corpus A.Perea-Garduno Department of Research and Development Altos Hornos de MexicoS.A.B.de C.V.Prolongacion JuarezS/NLa Loma.25770 Monclova.CoahuilaMexico

It has recently been reported that coal tar pitch(CTP)can be utilised as raw material for the production of graphene nanocapsules(GNCs)because it is formed by a great quantity of aromatic organic compounds(which promote the rearrangement of double bonds by a process of polymerisation).Due to the importance of graphene and the search for a non-expensive methodology to produce it,this work used CTP to synthesise GNCs using an in situ activation technique at low temperatures and evaluating the effect of the working temperature on the formation of such *** other words,analysing the form of the particle as the temperature rises from 600 to 900℃.As result of the experimentation,powders were obtained and analysed by the techniques of X-Ray Diffraction,Raman Spectroscopy and Microscopy,employing Field Fmission Scanning Electron Microscopy by normal mode as well as by Scanning Transmission Electron Microscopy and a High-Resolution Scanning Electron *** results show that working with temperatures between 800 and 850℃promotes the production of GNCs,considering that their size reduces as the working temperature rises.

关键词： Synthesis nanocapsule Graphene Tar Agglomeration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gas-blasting nanocapsules to accelerate carboplatin lysosome release and nucleus delivery for prostate cancer treatment

引用

Asian Journal of Pharmaceutical Sciences 2021年第2期16卷 192-202页

作者： Shunli Fu Shuang Liang Dandan Jiang Rui Yang Zipeng Zhang Lili Chang Xinke Zhang Yongjun Liu Na Zhang Department of Pharmaceutics Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China

To improve therapeutic effect and reduce severely side effects of carboplatin(CBP),the gas-generating nanocapsules were developed to accelerate CBP lysosome release and nucleus ***/SB-NC was prepared by co-loading CBP and NaHCO 3(SB)in nanocapsules using w/o/w emulsification solvent *** exhibited vesicle-like spherical morphology,uniform particle size and negative zeta *** the tumor site with a relatively high concentration is the first step for CBP delivery and the results showed that CBP/SB-NC could effectively increase drug accumulation at tumor *** that,the drug delivery carriers need to be internalized into tumor cells and the in vitro cellular uptake ability results showed CBP/SB-NC could be internalized into RM-1 cells more efficient than CBP *** internalized by RM-1 cells,the gas-blasting release process was tested in acid *** was demonstrated that 5 mg/ml NaHCO 3 was optimal to achieve pH-responsive gas-blasting *** vitro release results showed that CBP significantly rapid release in acid environment(pH 5.0)compared to neutral pH(pH 7.4)(P<0.05).Meanwhile,TEM and the change of the concentration of H+results exhibited that the explosion of CBP/SB 5-NC was more easily happened in lysosome acid environment(pH 5.0).The blasting release can accelerate CBP lysosome release to ***,the nucleus delivery results showed CBP/SB 5-NC can promote pH-triggered rapid nucleus *** the results of Pt-DNA adduct assay showed that the binding efficiency between CBP and DNA of CBP/SB 5-NC was higher than CBP *** last,in vitro and in vivo anti-tumor efficacy proved that CBP/SB 5-NC could enhance anti-tumor activity for prostate cancer ***/SB 5-NC also showed superior safety in vitro and in vivo by hemolysis assay and histopathological *** of the results demonstrate that CBP/SB 5-NC would be an efficient gas-blasting release formulation to enhance prostate cance

关键词： Carboplatin nanocapsule pH-responsive release Gas-blasting Prostate cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced Cryogenic Magnetocaloric Effect Induced by Small Size GdNi_5 Nanoparticles

引用

Journal of Materials Science & Technology 2014年第10期30卷 973-978页

作者： Jun Li Song Ma Han Wang Wenjie Gong Jingjing Jiang Shaojie Li Yong Wang Dianyu Geng Zhidong Zhang Shenyang National Laboratory for Materials Science Institute of Metal Researchand International Centre for Materials PhysicsChinese Academy of Sciences

GdNi5 nanoparticles and GdNis/Gd2O3 nanocapsules （with GdNi5 core and Gd2O3 shell） were prepared by arcdischarge technique under different hydrogen partial pressure. The GdNi5 nanoparticles show irregular spherical shape and have a size distribution of 10-50 nm with an average diameter of 15 nm. In comparison, the GdNi5/Gd2O3 nanocapsules present spherical morphology and show a size distribution of 10-100 nm with an average diameter of 60 nm. Under a magnetic field change of 50 kOe, the maximum magnetic entropy change of GdNi5 nanoparticles is 13.5 J/（kg K） at 5 K, while the corresponding value of the GdNis/Gd2O3 nanocapsuels is only 5.7 J/（kg K） at 31 K. The origin of the large magnetic entropy change of GdNi5 nanoparticles is ascribed to its high atomic moments and small anisotropy energy barrier induced by its small particle size.

关键词： Nanoparticle Superparamagnetic property Cryogenic refrigeration Magnetocaloric effect nanocapsule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation of stimuli-responsive nano-sized capsules based on cyclodextrin polymers with redox or light switching properties

引用

Nano Research 2016年第7期9卷 2070-2078页

作者： Ewelina Wajs Thorbjorn T. Nielsen Kim L. Larsen Alex Fragoso Nanobiotechnology & Bioanalysis Group Departament d'Enginyeria Quimica Universitat Rovira i Virgili Avinguda Paisos Catalans 26 43007 Tarragona Spain Department of Chemistry and Biosciences Aalborg University Frederik Bajers Vej 7H 9220 Aalborg SO Denmark

We report the preparation and encapsulation properties of stimuli-responsive nanocapsules, self-assembled by the noncovalent interactions of cyclodextrin- appended polymers （host） and complementary ferrocene or azobenzene carriers （guest）. The encapsulation process was significantly accelerated by applying （electro） chemical or light stimulus, enabling the easier and faster diffusion of guest molecules through the polymer layers. The nanocapsules were characterized by dynamic light scattering, confocal microscopy, ESEM, AFM, W-visible and fluorescence spectroscopy, and electrochemical techniques. The encapsulation and release properties of the nanocapsules were reversible and could be repeated several times, indicating that the prepared nanoassemblies are very stable.

关键词： nanocapsule cyclodextrin,ferrocene,azobenzene,stimuli-responsive materials,encapsulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：