Preparation of pH-Responsive Doxorubicin Nanocapsules by Combining High-gravity Antisolvent Precipitation with In-situ Polymerization for Intracellular Anticancer Drug Delivery

作     者：LIU Jie CHEN Bo ZHANG Jianjun LIU Jie;CHEN Bo;ZHANG Jianjun

作者机构：College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029P.R.China State Key Laboratory of NBC Protection far CivilianBeijing 102205P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2020年第36卷第5期

页      面：927-933页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China(Nos.2147601&21622601) the National Key R&D Pro gram of China(No.2015CB932101) 

主　　题：pH-Responsive Nanocapsule In-situ polymerization High-gravity anti solvent precipitation Anticancer cheniotherapy 

摘      要：Owing to the low pH value in tumor and cancer cells,drug delivery systems based on pH-responsive polymer nanocarriers have been extensively explored for anticancer ***,we developed a pH-responsive doxonibicin(EXDX)nanocapsule(named as DNanoCapsule)prepared by combining in-situ polymerization teclinique with high-gravity antisolvent precipitation technique throngh an amphiphilic polymerized surface *** show an obvious spherical core-shell structure with a single DOX nanoparticle encapsulated in the polymer *** rate studies prove that the DNanoCapsules have robust dnig-release profiles under acidic environments due to the division of the pH-sensitive cross-linker,which triggers thecollapse of the polymer *** in vitro investigations demonstrated that the DNanoCapsules exhibited higli cellular uptake efficiency and cytotoxicity for both HeLa and MCF-7 cancer ***,this work may provide a promising strategy to design and develop various stimuli-responsive drug nanocapsules tor the treatment of cancer or other diseases.