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Zeptomole Imaging of Cytosolic MicroRNA Cancer Biomarkers with A Light-Controlled nanoantenna

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Nano-Micro Letters 2021年第12期13卷 468-482页

作者： Yang Song Xiaoli Cai Grayson Ostermeyer Shichao Ding Dan Du Yuehe Lin School of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA Nanosong Systems LLC RedmondWA 98052USA School of Biological Sciences Washington State UniversityPullmanWA 99164USA

Detecting and quantifying intracellular microRNAs(miRNAs)are a critical step in resolving a cancer diagnostic and resolving the ensemble of gene products that orchestrate the living state of ***,the nanoprobe for detecting low abundance miRNAs in cell cytosol is restricted by either the"one-to-one"signaltrigger model or di culty for cytosol *** address these challenges,we designed a lightharvesting nanoantenna-based nanoprobe,which directs excitation energy to a single molecule to sensitively detect cytosolic *** light irradiation,the light-harvesting nanoantenna e ectively disrupted lysosomal structures by generationof reactive oxygen species,substantially achieved cytosol *** nanoantenna containing>4000 donor dyes can e ciently transfer excitation energy to one or two acceptors with 99%e ciency,leading to unprecedented signal amplification and biosensing *** designed nanoantenna can quantify cytosolic miR-210 at zeptomolar *** fluorescence lifetime of the donor exhibited good relationship with miR-210 concentration in the range of 0.032 to 2.97 amol/*** zeptomole sensitivity of nanoantenna provides accurate bioimaging of miR-210 both in multiple cell lines and in vivo assay,which creates a pathway for the creation of miRNA toolbox for quantitative epigenetics and personalized medicine.

关键词： Light-harvest nanoantenna miRNA detection Zeptomole Multiple cell lines

Nonlinear frequency conversion in optical nanoantennas and metasurfaces:materials evolution and fabrication

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Opto-Electronic Advances 2018年第10期1卷 1-12页

作者： Mohsen Rahmani Giuseppe Leo Igal Brener Anatoly V. Zayats Stefan A. Maier Costantino De Angelis Hoe Tan Valerio Flavio Gili Fouad Karouta Rupert Oulton Kaushal Vora Mykhaylo Lysevych Isabelle Staude Lei Xu Andrey E. Miroshnichenko Chennupati Jagadish Dragomir N. Neshev Research School of Physics and Engineering The Australian National University Canberra ACT 2601 Australia Matériaux et Phénomènes Quantiques Université Paris Diderot-Sorbonne Paris Cité 10 rue A. Domon et L. Duquet 75013 Paris France Center for Integrated Nanotechnologies Sandia National Laboratories Albuquerque New Mexico 87185 United States Department of Physics King’s College London Strand London WC2R 2LS United Kingdom The Blackett Laboratory Department of Physics Imperial College London London SW7 2AZ United Kingdom Chair in Hybrid Nanosystems Nano Institute Munich Fakultat für Physik Ludwig-Maximilians-Universitat München München Germany Deptartment of Information Engineering Universitàdegli Studi di Brescia and INO-CNR Via Branze 38 25123 Brescia Italy Institute of Applied Physics Abbe Center of Photonics Friedrich Schiller University Jena 07745 Jena Germany School of Engineering and Information Technology University of New South Wales Canberra ACT 2600 Australia

Nonlinear frequency conversion is one of the most fundamental processes in nonlinear *** has a wide range of applications in our daily lives,including novel light sources,sensing,and information *** is usually assumed that nonlinear frequency conversion requires large crystals that gradually accumulate a strong ***,the large size of nonlinear crystals is not compatible with the miniaturisation of modern photonic and optoelectronic ***,shrinking the nonlinear structures down to the nanoscale,while keeping favourable conversion efficiencies,is of great importance for future photonics *** the last decade,researchers have studied the strategies for enhancing the nonlinear efficiencies at the nanoscale,*** employing different nonlinear materials,resonant couplings and hybridization *** this paper,we provide a compact review of the nanomaterials-based efforts,ranging from metal to dielectric and semiconductor nanostructures,including their relevant nanofabrication techniques.

关键词： nonlinear nanophotonics metallic nanoantennas dielectric nanoantennas III-V semiconductor nanoantenna nanofabrication

All-dielectric metasurface beam deflector at the visible frequencies

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光电工程 2017年第1期44卷 103-107页

作者： Daopeng Wang Qingbin Fan Jiaxing Wang Zijie Zhang Yuzhang Liang Ting Xu National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced Microstructures Nanjing University

Beam deflectors are important optical elements which can control the propagation direction of the beam in free ***,with the development of miniaturization of the optical systems,conventional reflector-based mechanical beam deflectors confront a huge challenge due to their large sizes and incompatibility to the device *** we propose an all-dielectric flat metasurface beam deflector which is composed of a single layer array of TiO_2 nanoantennas resting on a fused-silica *** simulations are performed to demonstrate that the proposed deflectors are able to efficiently deflect the incident beam for different angles with transmission efficiency higher than 80%at visible *** ultrathin all-dielectric metasurface deflector may have great potential applications in integrated optics.

关键词： metasurfaces beam deflector nanoantenna integrated optics

Antenna-assisted picosecond control of nanoscale phase transition in vanadium dioxide

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Light(Science & Applications) 2016年第1期5卷 415-423页

作者： Otto L Muskens Luca Bergamini Yudong Wang Jeffrey M Gaskell Nerea Zabala CH de Groot David W Sheel Javier Aizpurua Physics and Astronomy Faculty of Physical Sciences and EngineeringUniversity of SouthamptonSouthampton SO171BJUK Department of Electricity and Electronics FCTZTFUPV-EHUBilbao 48080Spain Materials Physics Center CSIC-UPV/EHU and DIPCSan Sebastian 20018Spain Nano Group Faculty of Physical Sciences and EngineeringUniversity of SouthamptonSouthampton SO171BJUK Materials and Physics Research Centre University of SalfordManchester M54WTUK

Nanoscale devices in which the interaction with light can be configured using external control signals hold great interest for next-generation optoelectronic *** exhibiting a structural or electronic phase transition offer a large modulation contrast with multi-level optical switching and memory *** addition,plasmonic nanoantennas can provide an efficient enhancement mechanism for both the optically induced excitation and the readout of materials strategically positioned in their local ***,we demonstrate picosecond all-optical switching of the local phase transition in plasmonic antenna-vanadium dioxide(VO_(2))hybrids,exploiting strong resonant field enhancement and selective optical pumping in plasmonic ***-and wavelength-dependent pump–probe spectroscopy of multifrequency crossed antenna arrays shows that nanoscale optical switching in plasmonic hotspots does not affect neighboring antennas placed within 100 nm of the excited *** antenna-assisted pumping mechanism is confirmed by numerical model calculations of the resonant,antenna-mediated local heating on a picosecond time *** hybrid,nanoscale excitation mechanism results in 20 times reduced switching energies and 5 times faster recovery times than a VO_(2) film without antennas,enabling fully reversible switching at over two million cycles per second and at local switching energies in the picojoule *** hybrid solution of antennas and VO_(2) provides a conceptual framework to merge the field localization and phase-transition response,enabling precise,nanoscale optical memory functionalities.

关键词： insulator-metal phase transition nanoantenna plasmonics VO_(2)

On-chip wireless silicon photonics: from reconfigurable interconnects to lab-on-chip devices

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Light(Science & Applications) 2017年第1期6卷 517-527页

作者： Carlos García-Meca Sergio Lechago Antoine Brimont Amadeu Griol Sara Mas Luis Sánchez Laurent Bellieres Nuria S Losilla Javier Martí Nanophotonics Technology Center Universitat Politècnica de València46022 ValenciaSpain

Photonic integrated circuits are developing as key enabling components for high-performance computing and advanced networkon-chip,as well as other emerging technologies such as lab-on-chip sensors,with relevant applications in areas from medicine and biotechnology to *** demanding applications will require novel features,such as dynamically reconfigurable light pathways,obtained by properly harnessing on-chip optical *** this paper,we introduce a broadband,high directivity(4150),low loss and reconfigurable silicon photonics nanoantenna that fully enables on-chip radiation *** propose the use of these nanoantennas as versatile building blocks to develop wireless(unguided)silicon photonic devices,which considerably enhance the range of achievable integrated photonic *** examples of applications,we demonstrate 160 Gbit s−1 data transmission over mm-scale wireless interconnects,a compact low-crosstalk 12-port crossing and electrically reconfigurable pathways via optical beam ***,the realization of a flow micro-cytometer for particle characterization demonstrates the smart system integration potential of our approach as lab-on-chip devices.

关键词： integrated optics lab-on-a-chip devices nanoantenna sensing silicon photonics

Design of Carbon Nanotube Antenna in Nanoscale Range

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Open Journal of Antennas and Propagation 2021年第4期9卷 57-64页

作者： Muna Hajjyahya Maen Ishtaiwi Jeelan Sayyed Ayyam Saddouq Department of Physics An-Najah National University Nablus Palestine

In this paper, new values of efficiency for coated and non-coated carbon nanotube dipole antennas are found at different ranges of length and constant radius to have an effective model in wireless communication technology, biomedical engineering, sensors and solar cells. The main issue is to get matching between the antenna and the feeding source (discreet port). To have the best value of matching impedance by optimization method through entering trials of impedance value the aim of this paper is to have the best result of efficiency in each length. A new value of efficiency is shown for coated carbon nanotube dipole antennas, it is about 59%.

关键词： Carbon Nanotube nanoantenna Optimization Method