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An nir photothermal-responsive hybrid hydrogel for enhanced wound healing

Bioactive Materials 2022年第10期7卷 162-172页

作者： Lin Jin Xiaoqing Guo Di Gao Yan Liu Jiahua Ni Zhiming Zhang Yiqiao Huang Guibin Xu Zhe Yang Xingcai Zhang Xianhan Jiang Department of Urology The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510700PR China International Joint Research Laboratory for Biomedical Nanomaterials of Henan Zhoukou Normal UniversityZhoukou466001PR China The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an710049PR China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA Research Institute of Xi’an Jiaotong University HangzhouZhejiang311200PR China

Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the ***,we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure,that consists of MXene-loaded nanofibers(MNFs)as the core and dopamine-hyaluronic acid hydrogel(H)as the shell(MNFs@V-H@DA)to encapsulate a growth factor(vascular endothelial growth factor,VEGF,abbreviated as V)and H2S donor(diallyl trisulfide,DATS,abbreviated as DA).The continuous release of DA from this system produced H2S,which would successfully induce macrophages to polarize into M2-lile phenotype,regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound *** is conducive to the proliferation of skin cells,facilitating the wound *** addition,an appropriate amount of VEGF can be released from the MXene nanofibrous skeleton by adjusting the time of near-infrared(nir)light exposure,preventing excessive neovascularization and extracellular matrix deposition at the wound ***,this nir photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue.

关键词： Angiogenesis promotion nir response Hydrogel Nanofibers Scarless wound healing

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