An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

作     者：Lin Jin Xiaoqing Guo Di Gao Yan Liu Jiahua Ni Zhiming Zhang Yiqiao Huang Guibin Xu Zhe Yang Xingcai Zhang Xianhan Jiang 

作者机构：Department of UrologyThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510700PR China International Joint Research Laboratory for Biomedical Nanomaterials of HenanZhoukou Normal UniversityZhoukou466001PR China The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an710049PR China School of Engineering and Applied SciencesHarvard UniversityCambridgeMA02138USA School of EngineeringMassachusetts Institute of TechnologyCambridgeMA02139USA Research Institute of Xi’an Jiaotong UniversityHangzhouZhejiang311200PR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第10期

页      面：162-172页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(U1904176,82072808) Henan science and technology research project(222102520004)and Zhongyuan Thousand Talents Plan Project(L.Jin) Guangzhou Core Medical Disciplines Project(2021-2023) Guangdong foundation for basic and applied research(2019A1515010222) Biomedicine Joint Fund of Zhejiang Province(LWY20H180002) the China Postdoctoral Science Foundation(2019M663742) 

主　　题：Angiogenesis promotion NIR response Hydrogel Nanofibers Scarless wound healing 

摘      要：Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the ***,we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure,that consists of MXene-loaded nanofibers(MNFs)as the core and dopamine-hyaluronic acid hydrogel(H)as the shell(MNFs@V-H@DA)to encapsulate a growth factor(vascular endothelial growth factor,VEGF,abbreviated as V)and H2S donor(diallyl trisulfide,DATS,abbreviated as DA).The continuous release of DA from this system produced H2S,which would successfully induce macrophages to polarize into M2-lile phenotype,regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound *** is conducive to the proliferation of skin cells,facilitating the wound *** addition,an appropriate amount of VEGF can be released from the MXene nanofibrous skeleton by adjusting the time of near-infrared(NIR)light exposure,preventing excessive neovascularization and extracellular matrix deposition at the wound ***,this NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue.