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Functional characterization of the nf-kb binding site in the human NOD2 promoter

Cellular & Molecular Immunology 2010年第4期7卷 288-295页

作者： Chaofeng Hu Liping Sun Yiling Hu Daxiang Lu Huadong Wang Suisheng Tang Department of Pathophysiology Medical CollegeJinan UniversityGuangzhouChina Department of Physiology and Biophysics Faculty of MedicineDalhousie UniversityHalifaxNSCanada Data Mining Department Institute for Infocomm ResearchSingapore

Nucleotide-binding and oligomerization domain 2(NOD2),a member of the NOD protein family,plays an important role in innate *** response to pathogen attack,NOD2 stimulates cytokine and defensin production by activating nuclear factor(nf)-kb,a key transcription factor responsible for mediating downstream ***,the mechanism linking NOD2 regulation and nf-kb activation is poorly *** bioinformatics,we found a completely preserved canonical nf-kb binding site in the NOD2 core promoter(216 to 225 bp)in both humans and *** functional role of this nf-kb binding site was investigated using the enhanced green fluorescent protein(EGFP)reporter system,site-directed mutagenesis,the nf-kb activation inhibitor(JSH-23)and the chromatin immunoprecipitation(ChIP)*** results show that the nf-kb binding site is critical for regulation of the NOD2 *** deletion of the nf-kb binding elements within the NOD2 promoter or treatment with an nf-kb activation inhibitor could lead to a significant loss of NOD2 promoter activity as detected by reporter gene *** canonical nf-kb binding site was bound by nf-kb as determined by the ChIP *** on these results,we suggest a positive feedback regulation between nf-kb and NOD2,which may represent an efficient mechanism in response to pathogen invasion.

关键词： innate immunity nf-kb binding site NOD2 promoter

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