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n-terminal pro-b-type natriuretic peptide and diastolic function measurements by adenosine stress echocardiography in prediction of coronary stenosis in patients

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Chinese Medical Journal 2011年第14期124卷 2089-2095页

作者： ZHEnG Ping WAnG Hao TIAn Yue-qin GUO Yuan-lin HE Zuo-xiang LU Ye ZHEnG Xin MA Wen-jun XU nan SUn Xin ZHAnG Ling Department of Echocardiography Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China Department of nuclear Medicine Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China Center of Coronary Heart Diseases Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China Center of Hypertension Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

background Stress echocardiography is mainly used in detection of coronary artery disease （CAD） and to assess *** study aimed to use adenosine stress echocardiography （ASE） and n-terminal pro-b-type natriuretic peptide （nT-probnP） to noninvasively assess coronary stenosis in patients with chest pain syndromes or anginal *** nT-probnP was measured after overnight fast in fifty patients, 42 males and 8 females, who were （57＋11）years old. They then underwent echocardiography before and during adenosine administration. Left ventricular （LV）diastolic function analyzed included mitral annular early （E＇） and late velocity （A＇） both at the mitral septal and lateral level and the mitral inflow to annulus ratio （E/E＇）. Coronary angiography was performed the following day after which patients were assigned to three groups： normal results （16 patients）, stenosis 50%-69%（17 patients） and stenosis≥70% （17 patients）.Results nT-probnP levels in the groups of stenosis 50%-69% and≥ 70% were significantly higher than that in the group with normal results （P=0.014 and P=0.040）. During adenosine stress, the E/E＇ in the group of stenosis≥70% was higher than in the group of normal results （P=0.024）. E＇lateral/A＇lateral in the group of stenosis 50%-69% and E＇septal/A＇septal and E＇lateral/A＇lateral in the group of stenosis≥70% were also decreased during stress compared with baseline （P=0.003,P=0.001, P=0.022）. The variation of E＇septal/A＇septal before and during adenosine stress （△E＇septal/A＇septal） between the groups of normal results and stenosis ≥70% were significantly different （P=0.001）. by receiver operating characteristic （ROC）, the specificity of △E＇septal/A＇septal ≥0.037 predicting coronary stenosis ＜70% was 94%. The sensitivity and specificity of nT-probnP≥544.6 fmol/ml in predicting coronary stenosis ≥70% were 93% and 75%, ***-probnP inversely correlated with E＇lateral/A＇lateral （r=-0.390, P=0.014） and positively correlated with E/E＇lateral（r=0.55

关键词： adenosine echocardiography diastole coronary stenosis n-terminal pro-b-type natriuretic peptide

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Value of neutrophil/lymphocyte ratio,n-terminal pro-b-type natriuretic peptide,urea,and creatinine for the prediction of acute kidney injury in acute heart failure:a retrospective observational study

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Journal of bio-X Research 2021年第4期4卷 171-178页

作者： Lisi Huang Jian He Xianghua Lin Ling Luo Rihui Zhong Xiaoying Xie Xiaodan Peng Chaohui Duan Guangdong provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Clinical Laboratory Sun Yat-sen Memorial HospitalSun Yat-sen University State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong ProvinceChina

Objective:Early identification of acute kidney injury(AKI)is essential to improve the prognosis of patients with acute heart failure(AHF).We aimed to determine the utility of neutrophil/lymphocyte ratio(nLR),n-terminal prohormone of brain natriuretic peptide(nT-probnP),urea,and creatinine(Cr),as well as combinations of these,for the prediction of AKI in patients with ***:A total of 153 patients with AHF under the care of Sun Yat-sen Memorial Hospital,Sun Yat-sen University from October 2009 to October 2019 were included in this retrospective observational *** nLR,nT-probnP,urea,and Cr concentrations were measured on *** was defined using the Acute Kidney Injury network *** operating characteristic(ROC)curves,the areas under the curves(AUCs),sensitivity,and specificity were employed to evaluate the ability of each biomarker and their combinations to identify *** study was approved by the Ethics Committee of Sun Yat-sen Memorial Hospital,Sun Yat-sen University(approval ***-KY-KS-2021-126)on June 22,***:Forty-six(30.1%)participants developed AKI during *** nLR and nT-probnP of the participants with AKI were higher than those without(nLR:median 7.886 vs 4.717,PnT-probnP,median 6774 vs 2786pg/mL,Pnalyses demonstrated that high nLR and nT-probnP were associated with higher incidences of AKI(nLR:cut-off 5.681,AUC 0.716,sensitivity 58.9%,specificity 80.4%;nT-probnP:cut-off 5320pg/mL,AUC 0.700,sensitivity 72.9%,specificity 65.2%).Moreover,a combination of nLR,nT-probnP,urea,and Cr yielded an AUC of 0.815,sensitivity 80.4%,and specificity of 74.8%.In addition,the AUCs for the prediction of AKI in the participants with new York Heart Association(nYHA)classes II,III,and IV were 0.936,0.860,and 0.772,respectively,using this ***:A combination of nLR,nT-probnP,urea,and Cr,measured at admission,may represent a promising tool for the prediction of AKI in patients with

关键词： acute kidney injury creatinine neutrophil/lymphocyte ratio n-terminal pro-b-type natriuretic peptide urea

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The Relationship between Abnormal Circadian blood Pressure Rhythm and Risk of Readmission in Patients with Heart Failure with Preserved Ejection Fraction

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Cardiovascular Innovations and Applications 2021年第2期5卷 275-282页

作者： Diqing Wang Zhengfei He Sihua Chen Jianlin Du Department of Cardiology the First People’s Hospital of Fuyang District in HangzhouHangzhou311400China Department of Cardiology the Second Affi liated Hospital of Chongqing Medical UniversityChongqing400010China

Objective:Abnormal circadian blood pressure rhythm has been revealed to be associated with hypertensive target organ damage and cardiovascular events,but its association with readmission risk in patients with heart failure with preserved ejection fraction(HFpEF)remains *** conducted a retrospective study to explore the relationship between circadian blood pressure rhythm and readmission risk in HFpEF ***:We retrospectively collected baseline and follow-up data on HFpEF patients who underwent ambulatory blood pressure monitoring(AbPM)from May 2015 to October *** circadian blood pressure rhythms defi ned by AbPM were grouped as dipper,nondipper,or riser *** and multivariate linear regression analyses were performed to assess the association between circadian blood pressure rhythm and readmission ***:A total of 122 patients were enrolled in this *** mean age and ejection fraction were 69.87 years and 61.44%,respectively,with mean the n-terminal pro-b-type natriuretic peptide(nT-probnP)level being 1048.15 pg/*** were signifi cant differences in the 24-hour systolic blood pressure(SbP),sleep SbP,and sleep diastolic blood pressure(DbP)among the three groups,where the 24-hour SbP,sleep SbP,and sleep DbP in the riser pattern group were markedly higher than in the dipper pattern ***,serum nT-probnP levels,the proportion of patients readmitted for heart failure and the mean number of admissions differed markedly among three ***,multivariate linear regression analysis showed that the riser pattern was a signifi cant and independent risk factor for increased serum nT-probnP level(β=929.16,95%confi dence interval 178.79–1679.53,P=0.016).In multivariate logistic regression analysis,the riser pattern was demonstrated to be a signifi cant risk factor for readmission(odds ratio 11.23,95%confi dence interval 2.01–62.67,P=0.006)in HFpEF ***:The riser blood pressure pattern is a

关键词： Heart failure with preserved ejection fraction circadian blood pressure rhythm ambulatory blood pressure monitoring riser pattern n-terminal pro-b-type natriuretic peptide readmission

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prognostic value of hs-CR, nT-pro-bnP combined with GRACE score for short-term MACEs after PCI in STEMI patients

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South China Journal of Cardiology 2024年第4期25卷 232-237页

作者： WU Jiao Department of Emergency The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang421000China

background ST-elevated myocardial infarction(STEMI) is a common type of acute myocardial infarction with high morbidity, disability and mortality, which seriously threatens the life and health of patients. Percutaneous coronary intervention(PCI) is the preferred treatment for STEMI, which can quickly open blocked coronary arteries and restore myocardial blood perfusion, thus significantly improving the clinical symptoms and prognosis of patients. However, in clinical practice, STEMI patients still face a series of adverse events after PCI, major adverse cardiovascular events(MACEs) are predominant. Therefore, in order to accurately evaluate the short-term MACE after PCI in STEMI patients, it is particularly important to explore more sensitive and specific predictors. Methods Clinical data of 150 STEMI patients admitted to our hospital from June 2021 to May 2024 were retrospectively analyzed, and they were divided into MACEs group(n=42) and non-MACEs group(n=108) according to whether they developed MACEs within 6 months after PCI. The predictive values of highly sensitive C-reactive protein(hs-CRP), n-terminal pro-b-type natriuretic peptide(nT-pro-bnP), the Global Registry of Acute Coronary Events(GRACE) score and synthetic analysis for short-term MACEs after PCI in STEMI patients were respectively analyzed. Either GRACE score >140, hs-CRP level >3 mg/m L or nT-pro-bnP level >1000 pg/m L was considered positive. Synthetic analysis was defined as positive when at least two of the above indicators were positive. Multivariable logistic regression and receiver operation characteristic(ROC) analysis were applied to analyze prognostic values of hs-CR, nT-pro-bnP,GRACE score and synthetic analysis respectively for short-term MACEs after PCI in STEMI patients. Results The level of hs-CRP, nT-pro-bnP and GRACE score in MACEs group were higher than non-MACEs group(Pn analysis showed that hs-CRP, nT-probnP and GRACE score were all independent risk fact

关键词： ST-segment elevation myocardial infarction Percutaneous coronary intervention Highly sensitive C-reactive protein n-terminal pro-b-type natriuretic peptide Global Registry of Acute Coronary Events

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