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Supplementing n-carbamoylglutamate in late gestation increases newborn calf weight by enhanced placental expression of mTOR and angiogenesis factor genes in dairy cows

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Animal nutrition 2021年第4期7卷 981-988页

作者： Fengfei Gu Luyi Jiang Linyu Xie Diming Wang Fengqi Zhao Jianxin Liu Institute of Dairy Science College of Animal SciencesZhejiang UniversityHangzhou310058China Department of Animal and Veterinary Sciences University of VermontBurlingtonVT 05405USA

The objective of this study was to investigate whether supplementation with n-carbamoylglutamate(nCG)to cows during late gestation alters uteroplacental tissue nutrient transporters,calf metabolism and newborn *** multiparous Chinese Holstein cows were used in a randomized complete block design *** the last 28 d of pregnancy,cows were fed a diet without(COn)or with nCG(20 g/d per cow).The body weight of calves was weighed immediately after *** samples were collected at parturition and used to assess mRnA expression of genes involved in transport of arginine,glucose,fatty acid and angiogenesis factors,as well as the mammalian target of rapamycin(mTOR)*** samples of calves before colostrum consumption were also collected for the detection of plasma parameters,amino acids(AA)and metabolomics *** newborn weight(P=0.02)and plasma Arg concentration of nCG-calves was significantly higher(P=0.05)than that of COn-calves,and the plasma concentrations of urea nitrogen tended to be lower(P=0.10)in the nCG *** mRnA abundance of genes involved in glucose transport(solute carrier family 2 member 3[SLC2 A3],Pngiogenesis(nitric oxide synthase 3[nOS3],P=0.02),and mTOR pathway(serine/threonine-protein kinase 1[ACT1],P=0.10;euka ryotic translation initiation factor 4 B pseudogene 1[EIF4 BP1],P=0.08;EIF4 EBP2,P=0.04;and E74-like factor 2[ELF2],P=0.03)was upregulated in the placentome of nCG-supplemented *** addition,17 metabolites were significantly different in the placentome of nCG-supplemented cows compared to non-supplemented cows,and these metabolites are mainly involved in arginine and proline metabolism,alanine,aspartate and glutamate metabolism,and citrate *** summary,the increased body weight of newborn calves from the nCG supplemented dairy cows maybe attributed to the increased angiogenesis and uteroplacental nutrient transport and to the activated mTOR signal pathway,which may result in the increa

关键词： n-carbamoylglutamate Metabolomics newborn calf weight nutrient transporter Placentome Transition dairy cows

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Dietary supplementation with n-carbamoylglutamate initiated from the prepartum stage improves lactation performance of postpartum dairy cows

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Animal nutrition 2021年第1期7卷 232-238页

作者： Fengfei Gu Chao Miao Luyi Jiang Diming Wang Hongyun Liu Jianxin Liu Institute of Dairy Science MoE Key Laboratory of Molecular Animal NutritionCollege of Animal SciencesZhejiang UniversityHangzhou310058China

The objective of this study was to investigate the effects of supplementing n-carbamoylglutamate(nCG),an Arg enhancer,on amino acid(AA)supply and utilization and productive performance of early-lactating dairy *** multiparous Chinese Holstein dairy cows were randomly divided into con-trol(COn,n=15)and nCG(COn diet supplemented with nCG at 20 g/d per cow,n=15)groups at 4 wk before *** were offered individually in tie-stalls,and nCG was supplemented by top-dress feeding onto total mixed ration for the nCG *** experiment lasted until wk 10 after *** matter intake tended to be higher(P=0.06),and yields of milk(Pn(Pnd milk fat(Pn the nCG-cows than in the *** activities of aspartate aminotransferase(Pnine aminotransferase(P=0.03),and plasma level ofβ-hydroxybutyrate(P=0.04)were lower in the nCG-cows than in the COn-cows,whereas plasma glucose(P=0.05)and nitric oxide(nO,Pncentrations were *** vein concentrations of Cys(Pntial AA except Thr and His(Pntial AA(Pnd total AA(Pn the nCG-cows than in the *** arterial supply of all AA was greater in the nCG-cows than in the *** nCG-cows had higher mammary plasma flow of AA(P=0.04)and clearance rate of Cys(Pnd Asp(Pnd higher ratios of uptake to output of Met(P=0.05),Lys(Pnd Asp(P=0.01).In summary,addition of nCG initiated from the prepartum period improved the lactation performance of postpartum dairy cows,which might attribute to greater Arg and nO concentrations,as well as improved AA supply and utilization,liver function,and feed intake in these cows.

关键词： n-carbamoylglutamate Arginine Transition cow Lactation performance

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The significance of n‑carbamoylglutamate in ruminant production

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Journal of Animal Science and Biotechnology 2023年第5期14卷 1798-1814页

作者： Susan A.McCoard David Pacheco AgResearch Limited Grasslands Research CentreTennent DrivePrivate Bag 11008Palmerston North 4442New Zealand

Improving the efficiency and production of grazing ruminants to support food and fiber production,while reducing the environmental footprint and meeting the welfare needs of the animals,is important for sustainable livestock production *** of new technologies that can improve the efficiency of nitrogen(n)utilization in ruminants,and that are effective and safe,has important implications for ruminant livestock production.n-carbomoylglutamate(nCG)is a functional micronutrient that stimulates endogenous synthesis of arginine,which can improve survival,growth,lactation,reproductive performance,and feed efficiency in *** is a growing body of evidence to support the potential of dietary nCG supplementation to improve the productive capacity and n utilization efficiency of *** review summarizes the current literature on the effects of dietary supplementation with nCG in ruminants and impacts on production and potential to reduce the environmental footprint of farmed ruminant *** current literature highlights the potential for commercial application in ruminant livestock to improve productivity and n utilization efficiency.

关键词： Dairy Environment Fetal growth and development Lactation n-carbamoylglutamate nitrogen Red meat Reproduction

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