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Relationship of Microvascular Obstruction with Global and Regional myocardial function Determined by Cardiac Magnetic Resonance after ST-Segment Elevation myocardial Infarction

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Chinese Medical Sciences Journal 2023年第1期38卷 11-19页

作者： Ya-Nan Zhao Jia-Ning Cui Xing-Hua Zhang Jin-Feng Li Shi-Min Chen Xiu-Zheng Yue Tao Li Department of Radiology First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Epidemiology and Statistics graduate school of Chinese People’s Liberation Army General HospitalBeijing 100853China Philips Healthcare Beijing 100600China

Objective To investigate the impact of microvascular obstruction(MVO)on the global and regional myocardial function by cardiac magnetic resonance feature-tracking(CMR-FT)in ST-segment-elevation myocardial infarction(STEMI)patients after percutaneous coronary intervention.Methods Consecutive acute STEMI patients who underwent cardiac magnetic resonance imaging 1-7 days after successful reperfusion by percutaneous coronary intervention treatment were included in this retrospective study.Based on the presence or absence of MVO on late gadolinium enhancement images,patients were divided into groups with MVO and without MVO.The infarct zone,adjacent zone,and remote zone were determined based on a myocardial 16-segment model.The radial strain(RS),circumferential strain(CS),and longitudinal strain(LS)of the global left ventricle(LV)and the infarct,adjacent,and remote zones were measured by CMRFT from cine images and compared between patients with and without MVO using independent-samples t-test.Logistic regression analysis was used to assess the association of MVO with the impaired LV function.Results A total of 157 STEMI patients(mean age 56.66±11.38 years)were enrolled.MVO was detected in 37.58%(59/157)of STEMI patients,and the mean size of MVO was 3.00±3.76 mL.Compared with patients without MVO(n=98),the MVO group had significantly reduced LV global RS(t=-4.30,P<0.001),global CS(t=4.99,P<0.001),and global LS(t=3.51,P=0.001).The RS and CS of the infarct zone in patients with MVO were significantly reduced(t=-3.38,P=0.001;t=2.64,P=0.01;respectively)and the infarct size was significantly larger(t=8.37,P<0.001)than that of patients without MVO.The presence of LV MVO[OR=4.10,95%CI:2.05-8.19,P<0.001]and its size[OR=1.38,95%CI:1.10-1.72,P=0.01],along with the heart rate and LV infarct size were significantly associated with impaired LV global CS in univariable Logistic regression analysis,while only heart rate(OR=1.08,95%CI:1.03-1.13,P=0.001)and LV infarct size(OR=1.10,95%CI:1.03-1.16,P=0.003)were independent influencing fa

关键词： cardiac magnetic resonance feature tracking ST-segment elevation myocardial infarction microvascular obstruction myocardial strain myocardial function

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Effect of Moxibustion on Cardiac Remodeling and myocardial function in Rats with Exercise-Induced Fatigue

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 254-257页

作者： Zheng-Xian Shen Jie Zhu Yu-Lei Liang Zhi-Fang Zhang Diagnostics of Traditional Chinese Medicine Research Hebei University of Chinese MedicineShijiazhuangChina Information Technology Center Hebei Province Traditional Chinese Medicine HospitalShijiazhuangChina Moxibustion Research Hebei Key Laboratory of Chinese Medicine Research on Cardio‑Cerebrovascular DiseaseShijiazhuangChina

Objective:To explore the effect of moxibustion at Shenque(CV8)on myocardial structure and function in rats with exercise-induced fatigue.Methods:A 12-week treadmill training program was used to establish a rat model of exercise-induced fatigue.Fifty-six male SD rats removed six rats that did not reach the molding condition,Remaining rats were randomly divided into the following five groups:a normal group(n=10)that did not under go the exercise routine and were not treated,a control group(n=10)that did not under go the exercise routine,but received a mild dose of moxibustion at"Shenque"(CV 8)for 15 min,an untreated group(n=10)that received no treatment after exercise,a CV 8 group(n=10)that received a mild dose of moxibustion at"Shenque"(CV 8)for 15 min after exercise,a non-acupoint(tail)group(n=10)that received a mild dose of moxibustion at"non-acupoint"for 15 min after exercise.At one hour after the end of the 12-week training program,the left ventricular diastolic volume(LVDV),left ventricular systolic volume(LVSV),peak early diastolic mitral blood flow velocity(E),and peak late diastolic mitral blood flow velocity(A)were measured,and the E/A ratio were calculated.The serum myoglobin(Mb),creatine kinase-muscle/brain(CK-MB),and cardiac troponin-I(cTnI)levels were detected using an automatic biochemical analyzer.Results:When the values obtained before and after treatment were compared within the same groups,the LVDV,LVSV,E,and A were increased(P<0.05 or P<0.01),and the E/A were decreased(P<0.01)in the untreated group and the tail group.Regarding inter-group comparisons,the LVDV,LVSV,E,and A were increased(P<0.05 or P<0.01),and the E/A were decreased(P<0.01)in the untreated group and the tail group compared to the normal group and control group.Compared to the untreated group and the tail group,the LVDV,LVSV,E,and A were decreased(P<0.01)and the E/A were increased(P<0.01)in the CV 8 group.Compared to the normal group and the control group,the serum Mb,CK-MB,and cTnI levels were increased(P<0.01)in the untreated gro

关键词： Cardiac remodeling exercise-induced fatigue moxibustion myocardial function rats Shenque(CV8)

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Effects of Ginkgo biloba extract 50 on myocardial function in myocardium ischemic rats

Effects of Ginkgo biloba extract 50 on myocardial function i...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Ai-Hua LIU,Yi-Min BAO,Xing-Yu WANG,Zhi-Xiong ZHANG~* Shanghai University of Traditional Chinese Medicine,Shanghai 201203

＜正＞Objective:To study the effects of Ginkgo biloba extract 50（GBE50） on myocardial function,area at risk and myocardial ultra-structure in myocardium ischemic rats.Methods:Myocardium ischemia was induced by the left anterior descending（LAD） coronary artery occlusion and myocardial function was recorded.In vitro myocardial infarction was measured by 2,3,5-triphenyltetrazolium chloride（TTC） and Evans blue staining of heart sections.Standard hematoxylin and eosin（HE） staining was used for morphological evaluation by light microscopy. Results:Hemodynamic experiments in vivo showed that postischemic cardiac contractile function was reduced in ischemic rats.SM（7.5 g/kg/d×7） and GBE50（100 mg/kg/d×7） improved postischemic cardiac diastolic dysfunction. The area at risk was significantly reduced and myocardial structure was better-preserved in hearts of GBE50 group and SM group.Conclusions:GBE50 could attenuate myocardium damage induced by ischemia and provide potent myocardial protection.

关键词： GBE50 cardiac ischemia myocardial function area at risk ultra-structure

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Cardiac-specific knockout of ET_(A)receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction

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分子细胞生物学报:英文版 2012年第2期4卷 97-107页

作者： Yingmei Zhang Linlin Li Yinan Hua Jennifer M.Nunn Feng Dong Masashi Yanagisawa Jun Ren Department of Cardiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Center for Cardiovascular Research and Alternative Medicine University of WyomingLaramieWY 82071USA Department of Pharmacology Xinjiang Medical UniversityUrumqiXinjiang 830011P.R.China Howard Hughes Medical Institute University of Texas Southwestern Medical CenterDallasTX 75390USA

Cold exposure is associated with oxidative stress and cardiac dysfunction.The endothelin(ET)system,which plays a key role in myocardial homeostasis,may participate in cold exposure-induced cardiovascular dysfunction.This study was designed to examine the role of ET-1 in cold stress-induced cardiac geometric and contractile responses.Wild-type(WT)and ETA receptor knockout(ETAKO)mice were assigned to normal or cold exposure(48C)environment for 2 and 5 weeks prior to evaluation of cardiac geometry,contractile,and intracellular Ca21 properties.Levels of the temperature sensor transient receptor potential vanilloid(TRPV1),mitochondrial proteins for biogenesis and oxidative phosphorylation,including UCP2,HSP90,and PGC1a were evaluated.Cold stress triggered cardiac hypertrophy,depressed myocardial contractile capacity,including fractional shortening,peak shortening,and maximal velocity of shortening/relengthening,reduced intracellular Ca21 release,prolonged intracellular Ca21 decay and relengthening duration,generation of ROS and superoxide,as well as apoptosis,the effects of which were blunted by ETAKO.Western blotting revealed downregulated TRPV1 and PGC1a as well as upregulated UCP2 and activation of GSK3b,GATA4,and CREB in cold-stressed WT mouse hearts,which were obliterated by ETAKO.Levels of HSP90,an essential regulator for thermotolerance,were unchanged.The TRPV1 agonist SA13353 attenuated whereas TRPV1 antagonist capsazepine mimicked cold stress-or ET-1-induced cardiac anomalies.The GSK3b inhibitor SB216763 ablated cold stress-induced cardiac contractile(but not remodeling)changes and ET-1-induced TRPV1 downregulation.These data suggest that ETAKO protects against cold exposure-induced cardiac remodeling and dysfunction mediated through TRPV1 and mitochondrial function.

关键词： low ambient temperature myocardial function ET_(A)receptor TRPV1 mitochondria

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Left-sided vagus nerve stimulation improves cardiopulmonary resuscitation outcomes in rats as effectively as right-sided vagus nerve stimulation

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World Journal of Emergency Medicine 2021年第4期12卷 309-316页

作者： Wei-jing Shao Ting-ting Shu Shuang Xu Li-cai Liang Jehane Michael Le Grange Yu-ran Zhou He Huang Yu Cai Qing Zhang Peng Sun Department of Emergency Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Intensive Care Unit Wuhan Hospital of Traditional Chinese MedicineWuhan 430000China Department of Emergency Medicine the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Emergency Medicine Hankou Branch of Central Theater General HospitalWuhan 430070China Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

BACKGROUND: Our group previously reported that right-sided vagus nerve stimulation(RVNS) significantly improved outcomes after cardiopulmonary resuscitation(CPR) in a rat model of cardiac arrest(CA). However, whether left-sided vagus nerve stimulation(LVNS) could achieve the same effect as RVNS in CPR outcomes remains unknown.METHODS: A rat model of CA was established using modified percutaneous epicardial electrical stimulation to induce ventricular fibrillation(VF). Rats were treated with LVNS or RVNS for 30 minutes before the induction of VF. All animals were observed closely within 72 hours after return of spontaneous circulation(ROSC), and their health and behavior were evaluated every 24 hours.RESULTS: Compared with those in the RVNS group, the hemodynamic measurements in the LVNS group decreased more notably. Vagus nerve stimulation(VNS) decreased the serum levels of tumor necrosis factor-alpha(TNF-α) and the arrhythmia score, and attenuated inflammatory infiltration in myocardial tissue after ROSC, regardless of the side of stimulation, compared with findings in the CPR group. Both LVNS and RVNS ameliorated myocardial function and increased the expression of α-7 nicotinic acetylcholine receptor in the myocardium after ROSC. Moreover, a clear improvement in 72-hour survival was shown with VNS pre-treatment, with no significant difference in efficacy when comparing the laterality of stimulation. CONCLUSIONS: LVNS may have similar effects as RVNS on improving outcomes after CPR.

关键词： Vagus nerve stimulation Cardiac arrest Tumor necrosis factor-alpha myocardial function α-7 nicotinic acetylcholine receptor

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New Insight in the Assessment of Left Ventricular function in Paradoxical Low Flow Aortic Stenosis Patients with Normal Left Ventricular Ejection Fraction: A Mini-Review

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World Journal of Cardiovascular Surgery 2020年第12期10卷 264-270页

作者： Sherif Baath Allah Enrico Mangieri Jan Fedacko Petras Lohana Mohammed Elmahal Amena Elsaady Madian Abdelrahman Jaipaul Singh Mohamed Khorshid Ram B. Singh Galaleldin Nagib Elkilany RAK Medical and Health Science University Masafi Hospital Masafi UAE Cardiac Catheterization Department Sapienza University Rome Italy Internal Medicine Department Pavol Jozef Safárik University Kosice Slovakia Internal Medicine Department Masafi Hospital Fujairah UAE London University London UK Masafi Hospital Masafi UAE Oslo University Oslo Norway School of Natural Sciences University of Central Lancashire Preston UK Faculty of Medicine Zagazig University Zagazig Egypt Halberg Hospital and Research Institute Moradabad India Gulf Medical University Ajman UAE ARE AMMC Tanta University Dubai UAE

Paradoxical valvular aortic stenosis (VAS) is a challenging area of clinical cardiology for the practitioners. It involves a small aortic valve area, low flow rate and mean pressure gradient although there is normal left ventricular ejection fraction. The aim of this study was to assess left ventricular (LV) dysfunction in a symptomatic severe aortic valve stenosis which is of crucial importance in identifying patients at risk of heart failure, postoperative complications and increased mortality. There are new insights which are involved in assessment of LV myocardial function including global longitudinal strain (GLS) by two-dimensional speckle tracking echocardiography (2D STE), myocardial performance index (MPI) and maximum rate of LV pressure rise (+dP/dt) during isovolumetric contraction time of the LV. This information can provide both diagnostic and prognostic information in addition to standard echocardiographic and clinical parameters. However, a profound understanding of the complex interaction between loading conditions, chamber geometry and contractility is necessary for the correct interpretation of myocardial deformation in order to draw appropriate conclusions in patients with aortic valve disease. This mini review is related to new and novel insights into the assessment of left ventricular function (LVF) in paradoxical low flow aortic stenosis patients with normal left ventricular ejection fraction (LVEF).

关键词： Aortic Stenosis LVEF Aortic Valve myocardial function Global Longitudinal Stain Echocardiography

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Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy results of the IMAC(intervention in myocarditis and acute cardiomyopathy)-2 study

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South China Journal of Cardiology 2011年第3期 202-203页

Objectives:We sought to determine clinical and demographic predictors of recovery of left ventricular function for subjects with recent onset cardiomyopathy (ROCM).

关键词： cardiomyopathy echocardiography myocardial function outcomes recovery

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