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Histologic subtypes of non-muscle invasive bladder cancer

World Journal of Clinical Oncology 2024年第7期15卷 835-839页

作者： Nicola Giudici Roland Seiler Department of Urology Spitalzentrum BielBiel 2501Switzerland Department of BioMedical Research University of BernBern 3010Switzerland

The majority of bladder cancers(BCs)are non-muscle invasive BCs(NMIBCs)and show the morphology of a conventional urothelial carcinoma(UC).Aberrant morphology is rare but can be *** classification and characterization of histologic subtypes(HS)in UC in BC have mainly been described in muscle in-vasive bladder cancer(MIBC).However,the currently used classification is ap-plied for invasive urothelial neoplasm and therefore,also valid for a subset of *** standard transurethral diagnostic work-up misses the presence of HS in NMIBC in a considerable percentage of patients and the real prevalence is not *** in NMIBC are associated with an aggressive ***-quently,clinical guidelines categorize HS of NMIBC as“(very)high-risk”tumors and recommend offering radical cystectomy to these *** strategies for bladder preservation can only be offered to highly selected patients and ideally within clinical *** treatment strategies and biomarkers have been established MIBC and NMIBC but have not been comprehensively invest-igated in the context of HS in *** evaluation prior to implementation into clinical practice is needed.

关键词： Urothelial carcinoma Non-muscle invasive bladder cancer muscle invasive bladder cancer Histologic subtypes Histologic variants

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Role of gemcitabine and cisplatin as neoadjuvant chemotherapy in muscle invasive bladder cancer: Experience over the last decade

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Asian Journal of Urology 2019年第3期6卷 222-229页

作者： Sunny Goel Rahul J.Sinha Ved Bhaskar Ruchir Aeron Ashish Sharma Vishwajeet Singh Department of Urology King George Medical UniversityLucknowIndia

Objective:Neoadjuvant chemotherapy followed by radical cystectomy is considered the standard of care for patients with muscle invasive bladder *** the last decade,interest in neoadjuvant chemotherapy has slowly shifted from methotrexate,vinblastine,doxorubicin and cisplatin regime to gemcitabine and cisplatin *** are many publications on gemcitabine and cisplatin regime in literature which cover different aspects of *** review aims to summarise the findings published so far on gemcitabine and cisplatin regime and present it in a concise ***:A systematic literature review was conducted searching the PubMeddatabase in December 2016 using the medical subject heading(MeSH)with the terms gemcitabine,cisplatin,chemotherapy,muscle invasive bladder cancer,and *** relevant studies were included and results were ***:A total of 13 studies were included which published between 2007 and *** 13 studies comprised of 754 subjects suffering from muscle invasive bladder *** proportion of male patients ranged from 60%to 86.4%and the median age ranged from 54.2 to 77.3 years in various *** pathological response(pT0)was seen in 30.0%of patients and pathological downstaging(muscle invasive bladder *** is substantial pathological downstaging with low toxicity in patients of muscle invasive bladder cancer who receive neoadjuvant gemcitabine and cisplatin regime.

关键词： muscle invasive bladder cancer Gemcitabine Cisplatin Neoadjuvant chemotherapy Radical cystectomy

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