Histologic subtypes of non-muscle invasive bladder cancer

作     者：Nicola Giudici Roland Seiler 

作者机构：Department of UrologySpitalzentrum BielBiel 2501Switzerland Department of BioMedical ResearchUniversity of BernBern 3010Switzerland 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2024年第15卷第7期

页      面：835-839页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Urothelial carcinoma Non-muscle invasive bladder cancer Muscle invasive bladder cancer Histologic subtypes Histologic variants 

摘      要：The majority of bladder cancers(BCs)are non-muscle invasive BCs(NMIBCs)and show the morphology of a conventional urothelial carcinoma(UC).Aberrant morphology is rare but can be *** classification and characterization of histologic subtypes(HS)in UC in BC have mainly been described in muscle in-vasive bladder cancer(MIBC).However,the currently used classification is ap-plied for invasive urothelial neoplasm and therefore,also valid for a subset of *** standard transurethral diagnostic work-up misses the presence of HS in NMIBC in a considerable percentage of patients and the real prevalence is not *** in NMIBC are associated with an aggressive ***-quently,clinical guidelines categorize HS of NMIBC as“(very)high-risktumors and recommend offering radical cystectomy to these *** strategies for bladder preservation can only be offered to highly selected patients and ideally within clinical *** treatment strategies and biomarkers have been established MIBC and NMIBC but have not been comprehensively invest-igated in the context of HS in *** evaluation prior to implementation into clinical practice is needed.