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De novo strategy with engineering a multifunctional bacterial cellulose-based dressing for rapid healing of infected wounds

引用

Bioactive Materials 2022年第7期7卷 212-222页

作者： Chen Zhou Zhifei Yang Xiaowei Xun Le Ma Zejing Chen Xiaoming Hu Xidong Wu Yizao Wan Haiyong Ao Jiangxi Key Laboratory of Nanobiomaterials&Institute of Advanced Materials East China Jiaotong UniversityNanchang330000China Department of Drug Safety Evaluation Jiangxi Testing Center of Medical DeviceNanchang330000China

The treatment and healing of infected skin lesions is one of the major challenges in *** solve this problem,collagen I(Col-I)and the antibacterial agent hydroxypropyltrimethyl ammonium chloride chitosan(HACC)were composited into the bacterial cellulose(BC)three-dimensional network structure by a novel membrane-liquid interface(MLI)culture,and a Col-I/HACC/BC(CHBC)multifunctional dressing was *** water absorption rate and water vapor transmission rate of the obtained CHBC dressing were 35.78±2.45 g/g and 3084±56 g m^(-2)⋅day^(-1),*** water retention of the CHBC dressing was significantly improved compared with the BC caused by the introduced Col-I and *** vitro results indicated that the combined advantages of HACC and Col-I confer on CHBC dressings not only have outstanding antibacterial properties against Staphylococcus aureus(***)compared with BC and CBC,but also exhibit better cytocompatibility than BC and HBC to promote the proliferation and spread of NIH3T3 cells and *** importantly,the results of in vivo animal tests demonstrated that the CHBC dressings fully promoted wound healing for 8 days and exhibited shorter healing times,especially in the case of wound *** skin regeneration effects and higher expression levels of collagen during infection were also shown in the CHBC *** believe that CHBC composites with favorable multifunctionality have potential applications as wound dressings to treat infected wounds.

关键词： Bacterial cellulose Quaternized chitosan multifunctional dressing Antibacterial activity Healing promotion

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