De novo strategy with engineering a multifunctional bacterial cellulose-based dressing for rapid healing of infected wounds

作     者：Chen Zhou Zhifei Yang Xiaowei Xun Le Ma Zejing Chen Xiaoming Hu Xidong Wu Yizao Wan Haiyong Ao 

作者机构：Jiangxi Key Laboratory of Nanobiomaterials&Institute of Advanced MaterialsEast China Jiaotong UniversityNanchang330000China Department of Drug Safety EvaluationJiangxi Testing Center of Medical DeviceNanchang330000China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第7期

页      面：212-222页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work is supported by the National Natural Science Foundation of China(Grant No.31760265 and 82160355) grant awarded by Natural Science Foundation of Jiangxi Province(20171ACB21036 and 20192ACB80008) 

主　　题：Bacterial cellulose Quaternized chitosan Multifunctional dressing Antibacterial activity Healing promotion 

摘      要：The treatment and healing of infected skin lesions is one of the major challenges in *** solve this problem,collagen I(Col-I)and the antibacterial agent hydroxypropyltrimethyl ammonium chloride chitosan(HACC)were composited into the bacterial cellulose(BC)three-dimensional network structure by a novel membrane-liquid interface(MLI)culture,and a Col-I/HACC/BC(CHBC)multifunctional dressing was *** water absorption rate and water vapor transmission rate of the obtained CHBC dressing were 35.78±2.45 g/g and 3084±56 g m^(-2)⋅day^(-1),*** water retention of the CHBC dressing was significantly improved compared with the BC caused by the introduced Col-I and *** vitro results indicated that the combined advantages of HACC and Col-I confer on CHBC dressings not only have outstanding antibacterial properties against Staphylococcus aureus(***)compared with BC and CBC,but also exhibit better cytocompatibility than BC and HBC to promote the proliferation and spread of NIH3T3 cells and *** importantly,the results of in vivo animal tests demonstrated that the CHBC dressings fully promoted wound healing for 8 days and exhibited shorter healing times,especially in the case of wound *** skin regeneration effects and higher expression levels of collagen during infection were also shown in the CHBC *** believe that CHBC composites with favorable multifunctionality have potential applications as wound dressings to treat infected wounds.