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Radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1453-1465页

作者： Laurent Quéro Mouna Labidi Marc Bollet Côme Bommier Sophie Guillerm Christophe Hennequin Catherine Thieblemont Department of Radiation Oncology AP-HPSaint Louis HospitalParis 75010France Faculty of Medicine Universitéde ParisParis 75005France Department of Radiation Oncology Hartmann Oncology Radiotherapy GroupLevallois-Perret 92044France Hemato-Oncology DMU DHIAP-HPSaint Louis HospitalParis 75010France

Gastric mucosa-associated lymphoid tissue(MALT)lymphoma is a rare disease which is often associated with Helicobacter pylori(***)***-line treatment of stage IE and IIE localized gastric MALT lymphoma is based on the eradication of *** presence of *** resistance factors such as translocation t(11;18),peri-gastric lymph node involvement and the degree of tumor infiltration of the gastric wall;or lack of response to antibiotic therapy are two main indications to treat with definitive radiotherapy(RT).RT is an effective treatment in localized gastric MALT lymphoma.A moderate dose of 30 Gy allows a high cure rate while being well *** treatment,regular gastric endoscopic follow-up is necessary to detect a potential occurrence of gastric adenocarcinoma.

关键词： Radiotherapy mucosa-associated lymphoid tissue MALT Helicobacter pylori Lymphoma Review

Cutaneous mucosa-associated lymphoid tissue lymphoma complicating Sjögren's syndrome:A case report and review of literature

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World Journal of Clinical Cases 2022年第14期10卷 4509-4518页

作者： Ying Liu Jian Zhu Yan-Hong Huang Qian-Ru Zhang Li-Ling Zhao Ruo-Han Yu Department of Rheumatology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Rheumatology and Immunology The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND The association of Sjögren's syndrome(SS)and lymphoma is *** lymphoid tissue(MALT)or extranodal marginal zone B-cell lymphoma was the most common lymphomatous histology in SS *** in SS patients is frequently located in the parotid gland,while MALT lymphoma of the skin with SS is an exceedingly rare entity that needs to be *** SUMMARY A 60-year-old woman presented with a 3-year history of progressive dry mouth associated with a 1-year history of enlarging cutaneous *** examination revealed two hard subcutaneous nodules on her right lower *** results of Schirmer’s test were positive,despite the absence of dry *** salivary gland biopsy revealed lymphocytic infiltration and chronic inflammation with a focus score of *** patient was diagnosed with *** underwent resection of one cutaneous nodule,and histopathological analysis identified the nodule as MALT *** dry mouth symptoms improved,and the nodules decreased after 6 mo of treatment with hydroxychloroquine sulfate and chemotherapy(thalidomide,cyclophosphamide,and dexamethasone).CONCLUSION Lymphoma is a severe complication of SS,shown by the reported unique case of cutaneous MALT lymphoma with SS.

关键词： Sjögren's syndrome mucosa-associated lymphoid tissue Lymphoma Skin Nodule Case report

Laterally spreading tumor-like primary rectal mucosa-associated lymphoid tissue lymphoma:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3988-3995页

作者： Ya-Li Wei Cong-Cong Min Lin-Lin Ren Shan Xu Yun-Qing Chen Qi Zhang Wen-Jun Zhao Cui-Ping Zhang Xiao-Yan Yin Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Pathology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Colorectal mucosa-associated lymphoid tissue(MALT)lymphoma is a rare disease,and only a few cases have been reported to *** has no specific clinical presentations and shows various endoscopic *** is no uniform consensus on its *** the advancement of endoscopic technology,endoscopic treatment has achieved better results in individual case reports of early-stage *** SUMMARY We report a case of rectal MALT in a 57-year-old Chinese man with no symptoms who received endoscopy as part of a routine physical examination,which incidentally found a 25 mm×20 mm,laterally spreading tumor(LST)-like elevated lesion in the ***,he was referred to our hospital for further endoscopic *** and curable removal of the tumor was performed by endoscopic submucosal *** observed enlarged and dilated branch-like vessels similar to those of gastric MALT lymphoma on magnifying endoscopy with narrow-band *** immunopathological staining showed hyperplastic capillaries in the *** findings revealed diffusely hyperplastic lymphoid tissue in the lamina propria,with a visible lymphoid follicle structure surrounded by a large number of diffusely infiltrated lymphoid cells that had a relatively simple morphology and clear *** addition,immunohistochemical analysis suggested strongly positive expression for CD20 and *** rearrangement results showed positivity for IGH-A,IGH-C,IGK-B,and *** all the above findings together,we arrived at a diagnosis of extranodal marginal zone B-cell lymphoma of MALT lymphoma. Positron emission tomography-computed tomographyexamination showed no other lesions involved. The patient will be followed byperiodic endoscopic *** conclusion, we report a case of rectal MALT with an LST-like appearancetreated by endoscopic submucosal dissection. Further studies will be needed toexplore the clinical behavior, endoscopic appeara

关键词： Primary rectal mucosa-associated lymphoid tissue lymphoma Laterally spreading tumor Endoscopic submucosal dissection mucosa-associated lymphoid tissue Case report

Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma

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World Journal of Gastroenterology 2014年第11期20卷 2751-2759页

作者： Jeong Bae Park Ja Seol KooJeong Department of Internal Medicine College of MedicineDongguk UniversityGyeongju 780-350South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalAnsan 425-707South Korea

Gastrointestinal lymphoma is the most common type of extranodal lymphoma,and most commonly affects the *** zone B-cell lymphoma of the mucosa-associated lymphoid tissue(MALT)and diffuse large B-cell lymphoma are the most common histologic types of gastric *** its increasing incidence,diagnosis of gastric lymphoma is difficult at an earlier stage due to its nonspecific symptoms and endoscopic findings,and,thus,a high index of suspicion,and multiple,deep,repeated biopsies at abnormally and normally appearing sites in the stomach are *** addition,testing for Helicobacter pylori(***)infection and endoscopic ultrasonography to determine the depth of tumor invasion and involvement of regional lymph nodes is essential for predicting response to *** eradication and for assessment of disease *** addition,*** infection and MALT lymphoma development are associated,and complete regression of low-grade MALT lymphomas after *** eradication has been *** and/or chemotherapy can be used in cases that show poor response to *** eradication,negativity for *** infection,or high-grade lymphoma.

关键词： mucosa-associated lymphoid tissue Lymphoma Helicobacter pylori Eradication Remission

Colonic mucosa-associated lymphoid tissue lymphoma identified by chromoendoscopy

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World Journal of Gastroenterology 2014年第48期20卷 18487-18494页

作者： Sang-Wook Seo Seung-Hwa Lee Duck-Joo Lee Kwang-Min Kim Joon-Koo Kang Do-Wan Kim Jeong-Hun Lee Center for Health Promotion Department of Family Practice and Community Health Ajou University School of Medicine Suwon 443-380 South Korea Department of Gastroenterology Ajou University School of Medicine Suwon 443-380 South Korea Department of Anesthesiology Ajou University School of Medicine Suwon 443-380 South Korea Department of Surgery Ajou University School of Medicine Suwon 443-380 South Korea

Colonic mucosa-associated lymphoid tissue (MALT) lymphomas are a rare occurrence and the definitive treatment has not been established. Solitary or multiple, elevated or polypoid lesions are the usual appearances of MALT lymphoma in the large intestine and sometimes the surface may reveal abnormal vascularity. Herein, we report a case of MALT lymphoma and review the relevant literature. Upon colonoscopy, a suspected pathologic lesion was observed in the proximal transverse colon. The lesion could be distinguished more prominently after using narrow-band imaging mode and indigo carmine-dye spraying chromoendoscopy. Histopathologic examination of this biopsy specimen revealed lymphoepithelial lesions with diffuse proliferation of atypical lymphoid cells effacing the glandular architecture and centrocyte-like cells infiltrating the lamina propria. Immunohistochemical analyses showed that tumor cells were positive for CD20 and Bcl-2e, and negative for CD10, CD23, and Bcl-6. According to Ann-Arbor staging system, the patient had stage IIE. A partial colectomy with dissection of the paracolic lymph nodes was performed. Until now, there is no recurrence of lymphoma at follow-up.

关键词： Chromoendoscopy Lymphoma mucosa-associated lymphoid tissue Narrow-band imaging mode

Primary mucosa-associated lymphoid tissue lymphoma of the liver: A report of two cases and review of the literature

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World Journal of Hepatology 2017年第3期9卷 155-160页

作者： Ifeyinwa E Obiorah Lynt Johnson Metin Ozdemirli Department of Pathology Medstar Georgetown University Hospital Department of Surgery Medstar Georgetown University Hospital

mucosa-associated lymphoid tissue(MALT) lymphoma of the liver is a very rare condition and thus the diag-nosis may be challeng-ing-. The clinical presentation is usually variable, rang-ing- from minimal clinical symptoms to severe end stag-e liver disease. In this paper, we describe the clinicopatholog-ic finding-s in two cases of primary hepatic MALT lymphoma. One case is an 80-year-old female with no underlying- chronic liver disease and the second case is a 30-year-old female with autoimmune hepatitis complicated by MALT lymphoma. In both specimens, there was diffuse infiltration of atypical B-lymphocytes that were positive for CD20 and CD79 a, but neg-ative for CD5, CD43 and CD10. There were occasional lymphoepithelial lesions involving- the hepatocytes or bile ducts. Polymerase chain reaction analysis showed monoclonal immunog-lobulin heavy chain g-ene rearrang-ement in both cases. The first case was treated with surg-ery but developed pulmonary recurrence a year after complete resection but went into remission following- treatment with rituximab. A second recurrence occurred in the rig-ht parotid g-land 7 years later, which was treated with idelalisib. The second case was effectively treated with rituximab. To our knowledg-e, the second case is the first reported case linked to autoimmune hepatitis.

关键词： Extranodal mucosa-associated lymphoid tissue Lymphoepithelial Lymphoma Polymerase chain reaction

Marginal zone lymphoma with severe rashes: A case report

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World Journal of Clinical Cases 2024年第3期12卷 565-574页

作者： Si-Jun Bai Ye Geng Yi-Nan Gao Cai-Xia Zhang Qian Mi Chen Zhang Jia-Ling Yang Si-Jie He Zhen-YingYan Jian-Xia He Department of Hematology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial *** SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent ***-line treatment with rituximab combined with zanubrutinib had poor ***,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes *** For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be *** approach may provide a new perspective in the treatment of MZL.

关键词： Marginal zone lymphoma mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab,Obinutuzumab Zanubrutinib Case report

Gastrointestinal mucosal immunity and COVID-19

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World Journal of Gastroenterology 2021年第30期27卷 5047-5059页

作者： Tsvetelina Velikova Violeta Snegarova Alexander Kukov Hristiana Batselova Antoaneta Mihova Radislav Nakov Department of Clinical Immunology University Hospital LozenetzMedical FacultySofia UniversitySt.Kliment OhridskiSofia 1407Bulgaria Clinic of Internal Diseases Naval Hospital-VarnaMilitary Medical AcademyMedical FacultyMedical UniversityVarna 9000Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital"St George"Plovdiv 6000Bulgaria Clinic of Gastroenterology Tsaritsa Joanna University HospitalMedical University of SofiaSofia 1527Bulgaria

As the gastrointestinal tract may also be a crucial entry or interaction site of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the role of the gut mucosal immune system as a first-line physical and immunological defense is ***,gastrointestinal involvement and symptoms in coronavirus disease 2019(COVID-19)patients have been linked to worse clinical *** review discusses recent data on the interactions between the virus and the immune cells and molecules in the mucosa during the *** carrying out appropriate investigations,the mucosal immune system role in SARS-CoV-2 infection in therapy and prevention can be *** line with this,COVID-19 vaccines that stimulate mucosal immunity against the virus may have more advantages than the others.

关键词： mucosa Gut mucosa mucosa-associated lymphoid tissue SARS-CoV-2 COVID-19 Secretory immunoglobulin A Gut microbiota

Primary gastric non-Hodgkin lymphomas:Recent advances regarding disease pathogenesis and treatment

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World Journal of Gastroenterology 2021年第35期27卷 5932-5945页

作者： Michael D Diamantidis Maria Papaioannou Evdoxia Hatjiharissi Department of Hematology Thalassemia and Sickle Cell Disease UnitGeneral Hospital of LarissaLarissa 41221ThessalyGreece Division of Hematology First Department of Internal MedicineAHEPA General HospitalAristotle University of ThessalonikiThessaloniki 54636Greece

Primary gastric lymphomas(PGLs)are distinct lymphoproliferative neoplasms described as heterogeneous entities clinically and *** main histological types are diffuse large B-cell lymphoma(DLBCL)or mucosaassociated lymphoma *** has been one of the main fields of clinical research of our group in recent *** gastric DLBCLs are frequent,sufficient data to guide optimal care are *** today,a multidisciplinary approach has been applied,including chemotherapy,surgery,radiotherapy or a combination of these *** this minireview article,we provide an overview of the clinical manifestations,diagnosis and staging of these diseases,along with their molecular pathogenesis and the most important related clinical published *** then discuss the scientific gaps,perils and pitfalls that exist regarding the aforementioned studies,in parallel with the unmet need for future research and comment on the proper methodology for such retrospective *** to fill this gap,we retrospectively evaluated the trends in clinical presentation,management and outcome among 165 patients with DLBCL PGL who were seen in our institutions in *** study cohort was divided into two subgroups,comparing the main 2 therapeutic options[cyclophosphamide doxorubicin vincristine prednisone(CHOP)vs rituximab-CHOP(R-CHOP)].A better outcome with immunochemotherapy(R-CHOP)was *** the next 2 mo,we will present the update of our study with the same basic conclusion.

关键词： Primary gastric lymphoma Extranodal non-Hodgkin’s lymphoma Diffuse large B-cell lymphoma mucosa-associated lymphoid tissue Immunochemotherapy Rituximab-cyclophosphamide doxorubicin vincristine prednisone