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Diverse expression patterns of mucin 2 in colorectal cancer indicates its mechanism related to the intestinal mucosal barrier

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World Journal of Gastroenterology 2021年第25期27卷 3888-3900页

作者： Guo-Lian Gan Hua-Tao Wu Wen-Jia Chen Chun-Lan Li Qian-Qian Ye Yi-Feng Zheng Jing Liu Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Changjiang Scholar’s Laboratory Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Physiology Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Abnormal expression patterns of mucin 2(MUC2)have been reported in a variety of malignant tumors and precancerous *** MUC2 expression in the intestinal mucosa,caused by various pathogenic factors,is related to mechanical dysfunction of the intestinal mucosa barrier and increased intestinal mucosal ***,the relationship between MUC2 and the intestinal mucosal barrier in patients with colorectal cancer(CRC)is not *** To explore the relationship between MUC2 and intestinal mucosal barrier by characterizing the multiple expression patterns of MUC2 in *** Immunohistochemical staining was performed on intestinal tissue specimens from 100 CRC patients,including both cancer tissues and adjacent normal ***-linked immunosorbent assays were performed on preoperative sera from 66 CRC patients and 20 normal sera to detect the serum levels of MUC2,diamine oxide(DAO),and D-lactate(D-LAC).The relationship between MUC2 expression and clinical parameters was calculated by theχ2 test or Fisher’s exact *** value of MUC2 was evaluated by Kaplan-Meier curve and log-rank *** Immunohistochemical staining of 100 CRC tissues showed that the expression of MUC2 in cancer tissues was lower than that in normal tissues(54%vs 79%,P2 in CRC patients was higher than that in normal controls,and was positively associated with serum levels of human DAO(χ2=3.957,P2)=7.236,P2 was correlated with TNM stage,tumor type,and distant metastasis in CRC patients(P2 expression in CRC tissues predicted a poor *** MUC2 in tissues may play a protective role by participating in the intesti

关键词： Colorectal cancer mucin 2 mucin Expression Intestinal mucosal barrier Prognosis

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

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Food Science and Human Wellness 2024年第1期13卷 173-182页

作者： Xuejiao Zhang Ang Li Yuanyifei Wang Jin Wang Bowei Zhang Yan Zhang Jingmin Liu Shuo Wang Tianjin Key Laboratory of Food Science and Health School of MedicineNankai UniversityTianjin 300072China College of Food Science and Technology Hebei Agricultural UniversityBaoding 071001China

D-Psicose,as a low-calorie rare sugar,has attracted a lot of attention in recent years for alternating to *** anti-obesity effect of D-psicose has been extensively confirmed in previous studies,however,the impact of D-psicose on colitis remains ***,we firstly evaluated the effect of the D-psicose prophylactic intervention on dextran sulfate sodium-induced colitis in C57BL/6 *** pathological symptoms,inflammatory cytokines levels,gut microbiota composition,short chain fatty acids(SCFAs)production and colonic barrier integrity were comprehensively *** results confirmed that D-psicose intervention aggravated colitis,characterized by the exacerbation of colon shortening,increase of colonic inflammatory infiltration,and marked exaltation of disease activity indices and IL-6,IL-1βand TNF-α***,the dysfunction of gut microbiota was identified in the psicose *** abundance of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated while the abundance of probiotics Akkermansia and Lactobacillus were significantly down-regulated in the psicose group compared to the model ***,the production of SCFAs was suppressed in the psicose group,accompanied by a decrease in the level of mucin 2(Muc-2).Collectively,the underlying mechanism of the exacerbation of colitis by D-psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of SCFAs,which leads to the damage of the mucosal barrier and the intensifi cation of inflammatory invasion.

关键词： D-Psicose Colitis Gut microbiota Short chain fatty acids mucin 2

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Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei

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Cancer Biology & Medicine 2024年第7期21卷 586-605页

作者： Qidi Zhao Tian Wei Ru Ma Yubin Fu Rui Yang Yandong Su Yang Yu Bing Li Yan Li School of Clinical Medicine Tsinghua University Department of Surgical Oncology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Department of Peritoneal Cancer Surgery Beijing Shijitan Hospital Capital Medical University

Pseudomyxoma peritonei(PMP) is an indolent malignant syndrome. The standard treatment for PMP is cytoreductive surgery combined with intraperitoneal hyperthermic chemotherapy(CRS + HIPEC). However, the high recurrence rate and latent clinical symptoms and signs are major obstacles to further improving clinical outcomes. Moreover, patients in advanced stages receive little benefit from CRS + HIPEC due to widespread intraperitoneal metastases. Another challenge in PMP treatment involves the progressive sclerosis of PMP cell-secreted mucus, which is often increased due to activating mutations in the gene coding for guanine nucleotide-binding protein alpha subunit(GNAS). Consequently, the development of other PMP therapies is urgently needed. Several immune-related therapies have shown promise, including the use of bacterium-derived non-specific immunogenic agents, radioimmunotherapeutic agents, and tumor cell-derived neoantigens, but a well-recognized immunotherapy has not been established. In this review the roles of GNAS mutations in the promotion of mucin secretion and disease development are discussed. In addition, the immunologic features of the PMP microenvironment and immune-associated treatments are discussed to summarize the current understanding of key features of the disease and to facilitate the development of immunotherapies.

关键词： mutation Pseudomyxoma peritonei immune-related therapy mucin 2 tumor immuno-microenvironment

Effects of casein glycomacropeptide on the early development of primary colorectal cancer in rats

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Food Science and Human Wellness 2013年第3期2卷 113-118页

作者： Qingsen Chen Yun Liang Chenchen Zhu Yali Yan Guangchang Pang Tianjin Key Laboratory of Food Biotechnology College of Biotechnology and Food ScienceTianjin University of CommerceTianjin 300134China

In this paper,we utilized dimethylhydrazine(DMH)-induced colorectal cancer(CC)model rats to explore the effects of casein glycomacropeptide(CGMP)on colorectal *** with CC were orally administrated with 10,50,or 100 mg/kg bw d CGMP,or the same volume of phosphatebuffered saline for 15 *** total numbers of aberrant crypt foci(ACF)and crypts per focus in colon were scored using a light microscope at low magnification after the colon was stained with methylene blue *** methylation level of DNA extracted from colon was detected using methylation-specific *** expression of p16 and mucin 2(MUC2)proteins were measured by *** results showed that although ACF were found in rats treated with CGMP,their number was significantly decreased compared to that of model *** addition,methylation and expression levels of p16 and MUC2 were also inhibited by CGMP,which were more obvious in rats treated with 50 mg/kg bw d *** conclusion,CGMP has potential application as nutritional therapy for preventing colorectal cancer.©2013 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Casein glycomacropeptide Colorectal cancer DNA methylation p16 mucin 2

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