D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

作     者：Xuejiao Zhang Ang Li Yuanyifei Wang Jin Wang Bowei Zhang Yan Zhang Jingmin Liu Shuo Wang Xuejiao Zhang;Ang Li;Yuanyifei Wang;Jin Wang;Bowei Zhang;Yan Zhang;Jingmin Liu;Shuo Wang

作者机构：Tianjin Key Laboratory of Food Science and HealthSchool of MedicineNankai UniversityTianjin 300072China College of Food Science and TechnologyHebei Agricultural UniversityBaoding 071001China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第1期

页      面：173-182页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：funded by the National Natural Science Foundation of China(No.32030083) 

主　　题：D-Psicose Colitis Gut microbiota Short chain fatty acids Mucin 2 

摘      要：D-Psicose,as a low-calorie rare sugar,has attracted a lot of attention in recent years for alternating to *** anti-obesity effect of D-psicose has been extensively confirmed in previous studies,however,the impact of D-psicose on colitis remains ***,we firstly evaluated the effect of the D-psicose prophylactic intervention on dextran sulfate sodium-induced colitis in C57BL/6 *** pathological symptoms,inflammatory cytokines levels,gut microbiota composition,short chain fatty acids(SCFAs)production and colonic barrier integrity were comprehensively *** results confirmed that D-psicose intervention aggravated colitis,characterized by the exacerbation of colon shortening,increase of colonic inflammatory infiltration,and marked exaltation of disease activity indices and IL-6,IL-1βand TNF-α***,the dysfunction of gut microbiota was identified in the psicose *** abundance of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated while the abundance of probiotics Akkermansia and Lactobacillus were significantly down-regulated in the psicose group compared to the model ***,the production of SCFAs was suppressed in the psicose group,accompanied by a decrease in the level of mucin 2(Muc-2).Collectively,the underlying mechanism of the exacerbation of colitis by D-psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of SCFAs,which leads to the damage of the mucosal barrier and the intensifi cation of inflammatory invasion.