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Effects of ginger-partitioned moxibustion on the expression levels of PGF2α, E2, P, and mRNAs of PGF2αR and E2R in rats with primary dysmenorrhea due to cold-dampness stagnation

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Journal of Acupuncture and Tuina Science 2022年第2期20卷 104-110页

作者： LIU Chao LI Xinhua ZHOU Chenxi LIANG Yulei ZHANG Xuanping LIU Yucai ZHAO Zhiguo MA Xiaoshun Hebei University of Chinese Medicine Shijiazhuang050200China Key Research Office of Hebei Province Needling and moxibustion Techniques Effect Specificity Shijiazhuang050200China

Objective To observe the effects of ginger-partitioned moxibustion at Shenque(CV8)and Guanyuan(CV4)on the expression levels of endocrine-related molecules and their receptors in rats with primary dysmenorrhea(PD)due to cold-dampness stagnation,thus to explore their analgesic *** Thirty-two female Wistar rats were divided into a normal group,a model group,a ginger-partitioned moxibustion group,and a Western medicine group according to the random number table method,with 8 rats in each *** for rats in the normal group,all other rats were treated with oxytocin combined with ice-water bath to establish the rat models of PD due to cold-dampness *** successful modeling,rats in the normal group and the model group did not receive treatment;rats in the ginger-partitioned moxibustion group received treatments with ginger-partitioned moxibustion at Shenque(CV8)and Guanyuan(CV4);rats in the Western medicine group received ibuprofen by intragastric *** writhing response of rats was compared among groups,and the serum levels of prostaglandin F2α(PGF2α),estrogen(estradiol,E2),progesterone(P),and the mRNA expression of PGF2αand E2 receptors in the uterine tissues were *** No writhing behavior was observed in the normal group;compared with the normal group,the serum PGF2αand E2 levels in the model group were increased(Pmoxibustion group and the Western medicine group(Pmoxibustion group and the Western medicine group were decreased,while the P level was increased(P<0.05 or P<0.01);the mRNA expression levels of the uterine PGF2αand E2 receptors in the ginger-partitioned mox

关键词： moxibustion therapy Indirect moxibustion Ginger-partitioned moxibustion Dinoprost Estradiol Dysmenorrhea Rats

Clinical observation on acupoint pressure plus long-snake moxibustion for upper-limb spastic hemiplegia after cerebral infarction

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Journal of Acupuncture and Tuina Science 2021年第3期19卷 187-192页

作者： Wang Yu-chun Sun Hai-yan Zhang Fu-qing Traditional Chinese Medical Hospital of Taihe County Anhui ProvinceFuyang236601China 不详

Objective To observe the clinical efficacy of acupoint pressure plus long-snake moxibustion for upper-limb spastic hemiplegia after cerebral *** A total of 100 patients were randomized into a control group and an observation group,with 50 cases in each *** groups were treated with the same conventional internal medicine and rehabilitation *** control group was treated with additional acupoint pressure therapy,and the observation group was treated with long-snake moxibustion on the basis of the treatment given to the control *** Ashworth grade,Fugl-Meyer assessment upper limb scale(FMA-UL)and Barthel index(BI)were evaluated,and the root mean square(RMS)values of biceps brachii and flexor carpi radialis on the affected side were measured before and after *** efficacy was evaluated after *** After treatment,the total effective rate of the observation group was significantly higher than that of the control group(Pmoxibustion has great therapeutic efficacy for upper-limb spastic hemiplegia after cerebral *** can improve the degree of spasticity of the affected upper limb,reduce the muscle tone of biceps brachii and flexor carpi radialis on the affected side,and enhance the mobility of the aff

关键词： Acupuncture-moxibustion therapy Acupoint Pressure therapy moxibustion therapy Governor Vessel Cerebral Infarction Poststroke Syndrome Hemiplegia Muscle Spasticity

Effects of different doses of ginger-partitioned moxibustion on trefoil factor 1,mucin 5AC and epidermal growth factor receptor in rats with spleen deficiency syndrome

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Journal of Acupuncture and Tuina Science 2018年第1期16卷 1-7页

作者：贲定严宁炯杰徐寅罗燕李木清王云辉易展杨燕萍(译) Hunan University of Chinese Medicine Changsha 410208 China The First Hospital of Hunan University of Chinese Medicine Changsha 410007 China Hunan Academy of Chinese Medicine Changsha 410006 China 不详

To observe the effects of different doses of ginger-partitioned moxibustion on serum trefoil factor 1 （TFF1） and mucin 5AC （MUCSAC） levels, as well as the expression of epidermal growth factor receptor （EGFR） in gastric mucosa of rats with spleen deficiency syndrome, therefore, to explore the possible mechanism and the dose-effect characteristics of ginger-partitioned moxibustion in spleen deficiency syndrome. Methods： Seventy-five SPF grade Sprague-Dawley （SO） rats were randomly divided into a blank control group （group A）, a model group （group B）, a 3 moxa-cone ginger-partitioned moxibustion group （group C1）, a 6 moxa-cone ginger-partitioned moxibustion group （group C2） and a 9 moxa-cone ginger-partitioned moxibustion group （group C3） using random number table method, 15 rats in each group. Except group A, rats in the other groups received intragastric administration of 4 ~C 200% concentrated Da Huang （Radix et RhizomaRhei） to prepare spleen deficiency syndrome model. After successful modeling, rats in group B received no treatment; rats in group C1, C2 and C3 were treated with 3, 6 and 9 moxa-cone ginger-partitioned moxibustion at Zusanli （ST 36）and Zhongwan （CV 12） respectively for 8 continuous days. The general symptom score of rats was observed. The serum levels of TFF1 and MUC5AC were detected by enzyme-linked immunosorbent assay （ELISA）. The expression of EGFR protein in gastric mucosa was detected by immunohistochemistry. Results： After the treatment, compared with group A, the spleen deficiency symptom score was increased in group B, the levels of serum TFF1 and MUC5AC, the EGFR protein expression in gastric tissues of group C1, C2 and C3 were significantly increased （all P〈0.01）; compared with group B, the spleen deficiency scores were decreased in group C1, C2 and C3, and the serum levels of TFF1 and MUC5AC, as well as EGFR protein expression in gastric tissues were increased （all P〈0.01）. Compared with group C1, the spleen deficiency scores were decreas

关键词： moxibustion therapy Ginger-partitioned moxibustion Point, Zusanli (ST 36) Point, Zhongwan (CV 12) Researchon Acupoints Gastric Mucosal Damage Spleen Deficiency Syndrome Rats

Influence of herbal cake-partitioned moxibustion on lumbar functions and inflammatory factors in patients with lumbar disc herniation due to kidney deficiency and blood stasis

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Journal of Acupuncture and Tuina Science 2022年第5期20卷 370-375页

作者： BI Dingyan LI Hongliang HE Dao CAO Jianan OUYANG Lizhi LIU Huijuan WANG Jing YI Zhan ZHANG Kaiwei Hunan University of Chinese Medicine Changsha 410208China The First Hospital of Hunan University of Chinese Medicine Changsha 410007China Yueyang Hospital of Traditional Chinese Medicine Yueyang 414000China 不详

Objective To observe the efficacy of herbal cake-partitioned moxibustion for lumbar disc herniation(LDH)due to kidney deficiency and blood stasis and observe the influence of this method on lumbar functions and inflammatory factors in patients with this *** A total of 120 LDH patients who met the inclusion criteria were randomly divided into three groups,including a herbal cake-partitioned moxibustion group,a flour cake-partitioned moxibustion group,and a Western medication group,with 40 patients in each *** patients in the Western medication group were treated with diflunisal tablets,0.5 g per dose,2 doses a *** in the herbal cake-partitioned moxibustion group were treated with additional herbal cake-partitioned moxibustion group at Back-Shu Points and Jiaji(EX-B2)Points once a *** in the flour cake-partitioned moxibustion group were treated with the same methods as in the herbal cake-partitioned moxibustion group,except that the herbal cake was replaced by a flour *** the patients were treated for 10 *** treatment,the scores of the visual analog scale(VAS)and Japanese Orthopaedic Association(JOA)and the changes of the interleukin(IL)-6,tumor necrosis factor(TNF)-α,and substance P(SP)levels were observed,and the efficacy was *** After treatment,the VAS score and the levels of IL-6,TNF-α,and SP were lower than those before treatment,and the JOA score was higher than that before treatment in the three groups,indicating intra-group statistical significance(Pmoxibustion group were lower than those of the flour cake-partitioned moxibustion group and the Western medication group,while the JOA score of the herbal cake-partitioned moxibustion group was higher than that of the other two groups,indicating inter-group statistical significance(Pmoxibustion group was 92.5%,hi

关键词： moxibustion therapy Indirect moxibustion Medicinal Cake-partitioned moxibustion Inflammatory Factors Pain Measurement Intervertebral Disc Displacement Low Back Pain

Therapeutic efficacy and mechanism of heat-sensitive moxibustion for vascular dementia

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Journal of Acupuncture and Tuina Science 2020年第1期18卷 47-52页

作者： Wang Min-chao Lin Li-hong Zhang Fu-qing Lishui Second People’s Hospital Zhejiang 323000China 不详

Objective:To observe the clinical efficacy of heat-sensitive moxibustion for vascular dementia and explore its ***:A total of 70 patients with vascular dementia were randomized into an observation group and a control group,with 35 cases in each *** control group was treated with piracetam,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment of the control *** treatment lasted for 8 *** and after the treatment,the mini-mental state examination(MMSE),activity of daily living(ADL)and traditional Chinese medicine(TCM)symptom scores were assessed,and the levels of acetyl choline(Ach)and homocysteine(Hcy)were *** efficacy was evaluated after ***:The total effective rate of the observation group was significantly higher than that of the control group(P0.05);the plasma Ach level in the observation group increased significantly(Pmoxibustion plus piracetam is effective in treating vascular *** can significantly improve dementia symptoms and ADL,which may be related to the correction of plasma Ach and Hcy levels.

关键词： moxibustion therapy Moxa Stick moxibustion Heat-sensitive moxibustion Quality of Life Activities of Daily Living Mental Status and Dementia Tests Dementia,Vascular

Observation on the efficacy of moxibustion for chronic gastritis and a clinical study of moxibustion's effects on serum brain-gut peptides

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Journal of Acupuncture and Tuina Science 2016年第2期14卷 101-109页

作者：钱晨王硕硕吴焕淦赵继梦马晓芃黄任佳刘慧荣田甜孙艳红李璟施征 Shanghai University of Traditional Chinese Medicine Key Laboratory of Acupuncture-moxibustion and Immunological Effects Shanghai University of Traditional Chinese Medicine Yueyang Hospital of Integrated Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences

Objective： To investigate the efficacy and mechanisms of moxibustion-based treatment of chronic gastritis （CG）, and to provide an objective basis for treating CG using moxibustion. Methods： A total of 61 CG patients were divided into an herbal cake-partitioned moxibustion group and a mild-warm moxibustion group. In both treatment groups, bilateral Tianshu （ST 25）, Zhongwan （CV 12） and Qihai （CV 6） were selected for moxibustion. Before and after treatment, all the enrolled patients＇ gastrointestinal disease-related traditional Chinese medicine （TCM） syndrome scores and visual analog scale （VAS） scores were measured, and the changes in the serum levels of the brain-gut peptides ghrelin, somatostatin （SS） and motilin （MTL） were observed. Results： There was no statistically significant difference between the two groups in the clinical efficacy rate （P〈0.05）. After treatment, the gastrointestinal disease-related TCM syndrome scores and VAS scores were reduced to varying extents in both groups, the intra-group differences were statistically significant （all P〈0.01）. In both groups, the serum levels of ghrelin and MTL increased and the serum levels of SS decreased after treatment （all P〈0.01）. And there were no serious adverse events occurred. Conclusion： Both herbal cake-partitioned moxibustion and mild-warm moxibustion are effective for CG, these two therapies exhibited similar therapeutic efficacy of epigastric discomfort or pain. And both the two therapies act to anti-inflammation, promote the recovery of gastric mucosa and improve the gastric motility, which is possibly their crucial action mechanism in treating CD.

关键词： moxibustion therapy Gastritis Point, Tianshu (ST 25) Point, Zhongwan (CV 12) Point, O.ihai (CV 6) Mechanism

Clinical research of postpartum pantalgia treated with individualized moxibustion

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World Journal of Acupuncture-moxibustion 2022年第1期32卷 26-32页

作者： Wan-yu ZHANG Ying DING Bai-pu XU Shenzhen Pingle Orthopedics and Traumatology Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine Shenzhen Municipal Pingshan District Hospital of Traditional Chinese MedicineShenzhen 518118China

Objective:To evaluate the clinical therapeutic effect and safety of individualized moxibustion in treatment of postpartum ***:A total of 99 patients with postpartum pantalgia were divided into three group at the ratio of 1:1:1 according to random number table,*** individualized moxibustion group,a quantitative moxibustion group and a voltaren *** same acupoints were selected in the individualized moxibustion group and the quantitative moxibustion *** the patient in supine,Zhongwǎn(中脘CV12),Guānyuán(关元CV4),bilateral Tiānshū(天枢ST25),bilateral Xuèhǎi(血海SP10),bilateral Yanglingquan(阳陵泉GB34),bilateral Zúsānlǐ(足三里ST36) and bilateral Sānyīnjiāo(三阴交SP6) were *** the patient in prone,Dàzhuī(大椎GV14),bilateral Géshū(膈俞BL17),bilateral Píshū(脾俞BL20),bilateral Shènshū(肾俞BL23),Mìngmén 命门(GV4),bilateral Wěizhōng(委中BL40) and bilateral Yǒngquán(涌泉KI1) were *** the individualized moxibustion group,the moxibusion dose was determined by patient’s constitution and conditions as well as no occurrence of dry throat,thirst and local skin *** the quantitative moxibustion group,the moxibustion dose was fixed as 1 cone at each acupoint in *** these two groups,the treatment was given once every two days,three times a week and the treatment for 2 weeks was as 1 ***,2 courses of treatment were *** the voltaren group,voltaren ointment was used externally at the pain area,once a day,for 4 weeks ***,before treatment,at the end of treatment course and in follow-up,the symptom score of traditional Chinese medicine(TCM),pain score of visual analogue scale(VAS) and patient’s treatment satisfaction score were observed in the patients of the three ***:In comparison within group,TCM symptom score,VAS score and the treatment satisfaction score at the end of treatment were all reduced obviously as compared with those before treatment in each of the three groups(P <0.05).In 4,12 and 24 weeks of followup

关键词： Postpartum pantalgia moxibustion therapy Individualized moxibustion Randomized controlled trial(RCT)

Effect of moxibustion at Shenshu(BL 23) on the ethology,corticosterone and glucocorticoid receptor in aging rats

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Journal of Acupuncture and Tuina Science 2016年第4期14卷 250-256页

作者：雷菲沈文宾崔云华吴焕淦吴璐一刘慧荣包春辉赵继梦周次利赵琛杨燕萍(译) Shanghai R.esearch Institute of Acupuncture and Meridian Shanghai 200630China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Qigong Research Institute Shanghai 200030China 不详

Objective：To observe the effect of moxibustion on learning and memory abilities,corticosterone and glucocorticoid receptor（GR） in subacute aging ***：Twenty four Sprague-Dawley（SD） rats were randomly divided into a normal group,a model group and a moxibustion group,8 rats in each *** in the model group and the moxibustion group were subcutaneously injected with 25% D-galactose [125 mg/（kg·bw）] for 40 d continuous;rats in the normal group were injected with saline at the same position for 40 d *** in the moxibustion group were given mild moxibustion at bilateral Shenshu（BL 23） at the same time of modeling;rats in the normal group and the model group were only identically grabbed without moxibustion for 40 *** learning and memory abilities of rats were observed using the Morris water maze at the end of the *** aorta blood and thymus were collected after water maze ***-linked immunosorbent assay（ELISA） was used to detect serum corticosterone level,and immunohistochemical method was used to detect the expression of thymus ***：Compared with the normal group,rats in the model group showed that a significantly longer escape latency time（P〈0.01） on the third and the fourth days;number of times crossing the platform in 70 s significantly reduced（P〈0.01）;activity times in the fourth quadrant significantly decreased（P〈0.05）;serum corticosterone levels increased（P〈0.01）;thymus GR expression decreased（P〈0.05）.Compared with the model group,rats in the moxibustion group showed that the escape latency times were significantly shorter on the third,the fourth and the fifth days（P〈0.01,P〈0.05）;number of times crossing the platform in 70 s significantly increased（P〈0.05）;activity times in the fourth quadrant significantly increased（P〈0.05）;serum corticosterone levels decreased（P〈0.05）;thymus GR expression increased（P〈0.05）.Conclusion：moxibustion could improve the learning and memory abilities of subacute aging rats,down

关键词： moxibustion therapy Mild moxibustion Point Shenshu(BL 23) Aging Corticosterone Receptors Glucocorticoid

Effect of moxibustion on T lymphocyte subsets in peripheral blood of rats with gastric cancer

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Journal of Acupuncture and Tuina Science 2019年第3期17卷 161-167页

作者： Tan Jing Yang Ren-da Zhao Huan Peng Zhuo-jun Ouyang Li-zhi Lin Ya-ping Yang Yan-ping Hunan University of Chinese Medicine Changsha 410208China 不详

Objective:To observe the effect of moxibustion on T lymphocyte subsets in peripheral blood of rats with gastric cancer. Methods:Sixty healthy Sprague-Dawley (SD) rats were adaptively fed for one week. By the random number table method, 10 rats were randomly selected as a blank group, and 12 rats were randomly selected to simulate the tumor transplantation process;after transplantation, 10 rats were randomly selected as a sham operation group. The remaining 38 rats were used to prepare gastric cancer models by gastric transplantation of the Walker-256 tumor tissue;8 rats were randomly selected to verify the successful modeling after 7 d;the remaining 30 rats were randomly divided into a model group, a moxibustion group and an infrared group by the random number table method, with 10 rats in each group. From the first day of enrollment, the rats in the moxibustion group received mild moxibustion at Zhongwan (CV 12), Guanyuan (CV 4) and bilateral Zusanli (ST 36) (the first group) and bilateral Pishu (BL 20) and Weishu (BL 21) (the second group), and the two groups of acupoints were alternated every other day. The rats in the infrared group received infrared radiation on the stomach area and the area on the back between the T12-T13 spinous processes, the two areas were alternated every other day. Rats in the moxibustion group and the infrared group were treated for 20 min each time, once a day for 21 d. Rats in the blank group, the sham operation group, and the model group were simultaneously grasped and fixed, and no other treatment was performed. After 21 d of intervention, the rats in each group were fasted for 12 h, and blood was collected from the orbits. The numbers of CD3+, CD3+CD4+, CD3+CD8+ T lymphocytes in peripheral blood were determined by flow cytometry, and the ratio of CD3+CD4+/CD3+CD8+ was calculated. The rats were sacrificed and the thymus was dissected under sterile conditions to calculate the thymus index. Results:Compared with the blank group, the th

关键词： Acupuncture-moxibustion therapy moxibustion therapy Moxa Stick moxibustion Neoplasms Stomach T-lymphocytes Immunity, Cellular Rats