Effects of different doses of ginger-partitioned moxibustion on trefoil factor 1,mucin 5AC and epidermal growth factor receptor in rats with spleen deficiency syndrome
不同灸量隔姜灸对脾虚证大鼠三叶因子1、粘蛋白5AC及表皮生长因子受体的影响（英文）作者机构：Hunan University of Chinese Medicine Changsha 410208 China The First Hospital of Hunan University of Chinese Medicine Changsha 410007 China Hunan Academy of Chinese Medicine Changsha 410006 China 不详
出 版 物：《Journal of Acupuncture and Tuina Science》 (针灸推拿医学（英文版）)
年 卷 期：2018年第16卷第1期
页 面：1-7页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by Fund Project of Hunan Province Education Office,No.13C685 Graduate Student Research Innovation Project of Hunan Province,No.CX2016B351 Undergraduate Student Research Innovation Project of Hunan Province,No.201409060207~~
主 题：Moxibustion Therapy Ginger-partitioned Moxibustion Point, Zusanli (ST 36) Point, Zhongwan (CV 12) Researchon Acupoints Gastric Mucosal Damage Spleen Deficiency Syndrome Rats
摘 要：To observe the effects of different doses of ginger-partitioned moxibustion on serum trefoil factor 1 （TFF1） and mucin 5AC （MUCSAC） levels, as well as the expression of epidermal growth factor receptor （EGFR） in gastric mucosa of rats with spleen deficiency syndrome, therefore, to explore the possible mechanism and the dose-effect characteristics of ginger-partitioned moxibustion in spleen deficiency syndrome. Methods： Seventy-five SPF grade Sprague-Dawley （SO） rats were randomly divided into a blank control group （group A）, a model group （group B）, a 3 moxa-cone ginger-partitioned moxibustion group （group C1）, a 6 moxa-cone ginger-partitioned moxibustion group （group C2） and a 9 moxa-cone ginger-partitioned moxibustion group （group C3） using random number table method, 15 rats in each group. Except group A, rats in the other groups received intragastric administration of 4 ~C 200% concentrated Da Huang （Radix et RhizomaRhei） to prepare spleen deficiency syndrome model. After successful modeling, rats in group B received no treatment; rats in group C1, C2 and C3 were treated with 3, 6 and 9 moxa-cone ginger-partitioned moxibustion at Zusanli （ST 36）and Zhongwan （CV 12） respectively for 8 continuous days. The general symptom score of rats was observed. The serum levels of TFF1 and MUC5AC were detected by enzyme-linked immunosorbent assay （ELISA）. The expression of EGFR protein in gastric mucosa was detected by immunohistochemistry. Results： After the treatment, compared with group A, the spleen deficiency symptom score was increased in group B, the levels of serum TFF1 and MUC5AC, the EGFR protein expression in gastric tissues of group C1, C2 and C3 were significantly increased （all P〈0.01）; compared with group B, the spleen deficiency scores were decreased in group C1, C2 and C3, and the serum levels of TFF1 and MUC5AC, as well as EGFR protein expression in gastric tissues were increased （all P〈0.01）. Compared with group C1, the spleen deficiency scores were decreas
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