检索结果-南通市图书馆

Near infra-red light treatment of Alzheimer's disease

Journal of Innovative Optical Health Sciences 2018年第1期11卷 57-64页

作者： Mengmeng Han Qiyan Wang Xue Wang Yuhui Zeng Yong Huang Qingqiang Meng Jun Zhang Xunbin Wei Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University 1954 Huashan Road Shanghai 200030P.R.China Zhejiang BrainHealth Medical Technology Co.Ltd 332 Wangjiang Road Hangzhou 310002P.R.China Department of Neurosurgery General Hospital of PLA 28 Fuxing Road Beijing 100853 P.R.China

Alzheimers disease(AD)is a chronic neurodegenerative *** symptoms include memoryand spatial learning dificulties,language disorders,and loss of motivation,which get worse overtime,eventually ending in *** ffective treatments are available for AD,*** only attenuate symptoms temporarily and are associated with severe side ***-red(NIR)light has been studied for a long *** investigated the effect of NIR on ADusing a transgenic mouse model,which was obtained by co-injecting two vectors carrying ADmutations in amyloid precursor protein(APP)and presenilin-i(PSEN1)into C57BL/6J *** irradiation equipment consisted of an accommodating box and an LED *** wave-length of NIR light emitted from LED was between 1040 nm and 1090 *** power densitydelivered at the level of the mice was approximately 15 mW/cm^(2),Firstly,we treated the micewith NIR for 40 days,Then,the irradiation was suspended for 28 ***,another 15 daystreatment was brought to *** conducted Morris water maze and immunofluorescenceanalysis to evaluate the effects of *** analysis was based on mea-suring the quantity of plaques in mouse brain slices,Our results show that NIR light improvesmemory and spatial learning ability and reduces plaques *** light represents apotential treatment for AD.

关键词： Alzheimer's disease near infra-red light transgenic mouse model moris water maze immunofluorescence analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：