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Biomedical overview of melanin.2.Updating molecular modeling,synthesis mechanism,and supramolecular properties regarding melanoma therapy

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BIOCELL 2022年第6期46卷 1391-1415页

作者： JUAN CARLOS STOCKERT ALFONSO BLÁZQUEZ-CASTRO Facultad de Medicina Instituto de Oncología“Angel H.Roffo”Universidad de Buenos AiresBuenos AiresC1417DTBArgentina Centro Integrativo de Biología y Química Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiago8370854Chile Departamento de Biología Facultad de CienciasUniversidad Autónoma de MadridMadrid28049Spain

Melanins represent one of the most ancient and important group of natural macromolecular pigments.They have multiple biological roles in almost all organisms across the Phyla,examples being photoprotection,anti-oxidative action,radical scavenger activity,and heavy metal removal.From the biomedical point of view,melanocytes are involved in the origin of melanoma tumors,and the main therapeutic advances for their treatment have been revised in Part 1 of this review.The chemical structure of eumelanin is a biological concern of great importance,and therefore,exploring theoretical molecular models and synthesis mechanisms will be here described,as well as molecular orbital features and supramolecular organization,which are responsible for the key properties that make these biological pigments so important,and so fascinating.Ultimately,this updated overview is devoted to describe present structural models and physico-chemical characteristics of eumelanin,in order to explain and utilize melanin properties on which new photothermal and ultrasonic protocols for melanoma treatment can be devised and applied.

关键词： Eumelanin Melanin models Melanin synthesis molecular orbitals Supramolecular structure

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Spectroscopic properties of thulium ions in bismuth silicate glass

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Chinese Optics Letters 2012年第10期10卷 44-48页

作者：王欣胡丽丽李科峰田颖凡思军 Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Science Graduate Universitiy of Chinese Academy of Science Beijing 100049China

A new type of bismuth silicate glass （Bi2O3-SiO2-ZnO-Al2O3-La2O3） doped with Tm2O3 is prepared by melt-quenching method. The thermal stability of the glass is examined by differential scanning calorimetry. No crystallization peak is found. Using the absorption and emission spectra, the absorption and emission cross-sections are calculated. Their maximum data are 2.9×10^-21cm^2 at 1663 nm and 4.7×10^-21cm^2 at 1826 nm, respectively. Using the Judd-Ofelt theory, the radiation transition probabilities and radiative lifetimes are obtained. The extended overlap integral method is applied to analyze energy transfer process among the Tm3＋ ions. The transfer constants of cross-relaxation and energy migration among the Tm^3＋ ions at the 3H4 level are 7.60×10^-40 and 14.98×10^-40 cm^6 /s, respectively. The critical transfer radius for cross-relaxation is 0.99 nm. The cross relaxation process is easy to realize and is favorable for obtaining ～2-μm laser.

关键词： Bismuth Chemical bonds Differential scanning calorimetry Emission spectroscopy Energy transfer Glass Lanthanum oxides molecular orbitals Silicates Wave functions Zinc oxide

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