检索结果-南通市图书馆

Practical hints for the diagnosis of mixed neuroendocrine-nonneuroendocrine neoplasms of the digestive system

World Journal of Gastrointestinal Oncology 2024年第11期16卷 4326-4332页

作者： Paola Mattiolo Department of Diagnostics and Public Health Section of PathologyUniversity of VeronaUniversity and Hospital Trust of VeronaVerona 37134Italy Department of Pathology Heinrich Heine University and University Hospital of DuesseldorfDuesseldorf 40225Germany

In this editorial,a comment on the article by Díaz-López et al published in the recent issue of the 2024 is *** focus on the practical implications critical for providing a correct and complete diagnosis of mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)in the gastrointestinal *** diagnosis of MiNEN begins with the recognition of neuroendocrine features in one component of a biphasic *** non-neuroendocrine counterpart can be virtually represented by any neoplastic type,even though the most frequent histologies are glandular and ***,qualification of the neuroendocrine component requires histological and immunohistochemical *** tumors are characterized by a peculiar architectural organization and bland nuclei with granular“salt and pepper”*** neuroendocrine carcinomas have multiple and variable presentations,they typically show a solid or organoid *** histological aspect needs to be confirmed by immunohistochemistry,and a diagnosis is confirmed whenever the expression of keratin and neuroendocrine markers is *** both histopathological and immunohistochemical features of neuroendocrine neoplasms are identified,it is important to consider the three major pitfalls of MiNEN diagnostics:(1)Entrapment of neuroendocrine non-neoplastic cells within the tumor mass;(2)Differential diagnosis with amphicrine neoplasms;and(3)Differential diagnosis of tumors that partially express neuroendocrine *** to the current guidelines for diagnosing digestive MiNEN,each component must represent at least 30%of the entire neoplastic *** the high-grade histopathological subtype frequently determines disease prognosis,both components can significantly affect ***,if one of the components,either neuroendocrine or non-neuroendocrine,does not fulfill the volumetric criteria,the guidelines still encourage reporting *** strict criteria are essential for correct

关键词： mixed neuroendocrine-non-neuroendocrine neoplasm Digestive system neuroendocrine neoplasm Immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma:A case report and review of literature

引用

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1449-1460页

作者： Fei Chen Wei-Wei Li Juan-Fen Mo Min-Jie Chen Su-Hang Wang Shu-Ying Yang Zheng-Wei Song Department of Hepatobiliary Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina The Key Laboratory The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Intensive Medicine The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND neuroendocrine carcinoma(NEC)of the extrahepatic bile duct is very rare,and the treatment and prognosis are ***,we report the case of a middleaged female with primary large cell NEC(LCNEC)of the common hepatic duct combined with distal cholangiocarcinoma(dCCA).Additionally,after a review of the relevant literature,we summarize and compare mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)and pure NEC to provide a reference for selecting the appropriate treatment and predicting the prognosis of this rare *** SUMMARY A 62-year-old female presented to the hospital due to recurrent abdominal pain for 2 *** examination showed mild tenderness in the upper abdomen and a positive Courvoisier *** tests showed elevated liver transaminase and carbohydrate antigen 199 *** examination revealed node dissection was performed,and hepatic duct tumours were unexpectedly found during *** suggested poorly differentiated LCNEC(approximately 0.5 cm×0.5 cm×0.4 cm),Ki-67(50%),synaptophysin+,and chromogranin A+.dCCA pathology suggested moderately differentiated *** patient eventually developed lymph node metastasis in the liver,bone,peritoneum,and abdominal cavity and died 24 months after *** sequencing methods were used to compare gene mutations in the two primary bile duct *** The prognosis of MiNEN and pure NEC alone is different,and the selection of treatment options needs to be differentiated.

关键词： neuroendocrine carcinoma mixed neuroendocrine-non-neuroendocrine neoplasm Cholangiocarcinoma Extrahepatic bile duct Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Composite intestinal adenoma-microcarcinoid:An update and literature review

引用

World Journal of Gastrointestinal Endoscopy 2021年第12期13卷 593-606页

作者： Zhi-Yan Fu Michel Kmeid Mahmoud Aldyab Stephen M Lagana Hwajeong Lee Pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew YorkNY 10032United States

Composite intestinal adenoma-microcarcinoid(CIAM)is a rare intestinal lesion consisting of conventional adenoma and small,well differentiated carcinoid[microcarcinoid(MC)]at its *** incidence of CIAM is 3.8%in surgically resected colorectal *** its pathogenesis is unknown,studies support the role of Wnt/β-catenin pathway in the tumorigenesis of *** have been primarily reported in the colon wherein they present as polyps with well-defined margins,similar to conventional adenomatous *** is usually found in adenomatous polyps with high-risk features such as large size,villous architecture,or high grade ***,the MC component is often multifocal and spans 3.9 to 5.8 millimeters in *** is usually confined within the mucosa but occasional CIAM cases with MC extending to the submucosa have been *** of CIAM demonstrates bland cytology and inconspicuous proliferative *** lesional cells are positive for synaptophysin and 60%to 100%of cases show nuclearβ-catenin *** poses a diagnostic challenge with its morphologic and immunohistochemical resemblance to both benign and malignant lesions,including squamous morules/metaplasia,adenocarcinoma,squamous cell carcinoma,sporadic neuroendocrine tumor and goblet cell *** is an indolent lesion with a favorable *** removal by polypectomy is considered *** and recognition of this rare entity will help arrive at correct diagnosis and improve patient ***,CIAM is not recognized as a subtype of mixed neuroendocrine-nonneuroendocrine neoplasm by WHO.

关键词： Composite Adenoma Microcarcinoid Composite intestinal adenomamicrocarcinoid Wnt/β-catenin mixed neuroendocrine-non-neuroendocrine neoplasm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：