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A two-photon mitotracker based on a naphthalimide fluorophore:Synthesis, photophysical properties and cell imaging

Chinese Chemical Letters 2014年第7期25卷 1001-1005页

作者： Yong Dai Bao-Kuo Lv Xin-Fu Zhang Yi Xiao Department of Criminal Science and Technology Sichuan Police College State Key Laboratory of Fine Chemicals Dalian University of Technology Liaoning Water Environment Monitoring Center Shenyang Branch

PAHPN. a naphthalimide-based mitotracker with reasonable two-photon excitation emission activity and polarity-sensitive fluorescence properties has been efficiently synthesized and studied in twophoton, co-localizatio... 详细信息

关键词： mitotracker Mitochondria Namphthalimide Two-photon Fluorescence imaging

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Mitochondrial dysfunctions in neurodegenerative diseases:role in disease pathogenesis,strategies for analysis and therapeutic prospects

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Neural Regeneration Research 2022年第4期17卷 754-758页

作者： Federica Rey Sara Ottolenghi Gian Vincenzo Zuccotti Michele Samaja Stephana Carelli Department of Biomedical and Clinical Sciences“L.Sacco” University of MilanMilanoItaly Paediatric Clinical Research Centre Fondazione“Romeo ed Enrica Invernizzi” University of MilanoMilanoItaly Laboratory of Biochemistry Department of Health SciencesUniversity of MilanMilanoItaly Department of Paediatrics Children’s Hospital“V.Buzzi”MilanoItaly

Fundamental organelles that occur in every cell type with the exception of mammal erythrocytes,the mitochondria are required for multiple pivotal processes that include the production of biological energy,the biosynthesis of reactive oxygen species,the control of calcium homeostasis,and the triggering of cell *** disruption of anyone of these processes has been shown to impact strongly the function of all cells,but especially of *** this review,we discuss the role of the mitochondria impairment in the development of the neurodegenerative diseases Amyotrophic Lateral Sclerosis,Parkinson's disease and Alzheimer's *** highlight how mitochondria disruption revolves around the processes that underlie the mitochondria's life cycle:fusion,fission,production of reactive oxygen species and energy *** genetic and sporadic forms of neurodegenerative diseases are unavoidably accompanied with and often caused by the dysfunction in one or more of the key mitochondrial ***,in order to get in depth insights into their health status in neurodegenerative diseases,we need to focus into innovative strategies aimed at characterizing the various mitochondrial *** techniques include Mitostress,mitotracker,transmission electron microscopy,oxidative stress assays along with expression measurement of the proteins that maintain the mitochondrial *** will also discuss a panel of approaches aimed at mitigating the mitochondrial *** include canonical drugs,natural compounds,supplements,lifestyle interventions and innovative approaches as mitochondria transplantation and gene *** conclusion,because mitochondria are fundamental organelles necessary for virtually all the cell functions and are severely impaired in neurodegenerative diseases,it is critical to develop novel methods to measure the mitochondrial state,and novel therapeutic strategies aimed at improving their health.

关键词： Alzheimer's disease amyotrophic lateral sclerosis mitochondria mitochondria modulation mitochondrial dysfunction mitochondrial health Mitostress mitotracker neurodegenerative disease Parkinson's disease

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地塞米松诱导小鼠胸腺细胞凋亡中线粒体质量的变化

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中国药理学通报 2006年第5期22卷 563-567页

作者：王通曾耀英邢飞跃梁佩燕暨南大学组织移植与免疫教育部重点实验室广东广州510630

目的研究地塞米松(DEX)诱导的小鼠胸腺细胞凋亡中线粒体质量变化。方法分别设对照组(Control)和DEX组;在6 h,分别以NAO和M itotracker G reen(MG)单染流式细胞术检测线粒体质量变化,以D iOC6(3)染色流式细胞术检测线粒体膜电势变化,以An... 详细信息

目的研究地塞米松(DEX)诱导的小鼠胸腺细胞凋亡中线粒体质量变化。方法分别设对照组(Control)和DEX组;在6 h,分别以NAO和M itotracker G reen(MG)单染流式细胞术检测线粒体质量变化,以D iOC6(3)染色流式细胞术检测线粒体膜电势变化,以Annexin V-PE/MG双染流式细胞术检测细胞凋亡中线粒体质量改变特点。结果NAO染色检测结果显示终浓度1μmol.L-1DEX可以诱导小鼠胸腺细胞线粒体心磷脂含量降低,与对照组比较P<0.01;MG染色流式细胞术结果表明DEX(P<0.01)诱导了胸腺细胞线粒体质量的降低;DEX(P<0.01)诱导线粒体膜电势依赖性D iOC6(3)在胸腺细胞中可染性下降;Annexin V-PE/MG双染流式细胞术显示,凋亡细胞中存在一定比例的低线粒体质量细胞,DEX组该群细胞多于对照组(P<0.01)。结论DEX诱导小鼠胸腺细胞凋亡中线粒体质量降低;线粒体质量评价在细胞凋亡相关药理学研究领域有应用前景。

关键词：胸腺细胞凋亡线粒体质量 NAO mitotracker Green

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