Mitochondrial dysfunctions in neurodegenerative diseases:role in disease pathogenesis,strategies for analysis and therapeutic prospects

作     者：Federica Rey Sara Ottolenghi Gian Vincenzo Zuccotti Michele Samaja Stephana Carelli Federica Rey;Sara Ottolenghi;Gian Vincenzo Zuccotti;Michele Samaja;Stephana Carelli

作者机构：Department of Biomedical and Clinical Sciences“L.Sacco”University of MilanMilanoItaly Paediatric Clinical Research Centre Fondazione“Romeo ed Enrica Invernizzi”University of MilanoMilanoItaly Laboratory of BiochemistryDepartment of Health SciencesUniversity of MilanMilanoItaly Department of PaediatricsChildren’s Hospital“V.Buzzi”MilanoItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第4期

页      面：754-758页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：Alzheimer's disease amyotrophic lateral sclerosis mitochondria mitochondria modulation mitochondrial dysfunction mitochondrial health Mitostress Mitotracker neurodegenerative disease Parkinson's disease 

摘      要：Fundamental organelles that occur in every cell type with the exception of mammal erythrocytes,the mitochondria are required for multiple pivotal processes that include the production of biological energy,the biosynthesis of reactive oxygen species,the control of calcium homeostasis,and the triggering of cell *** disruption of anyone of these processes has been shown to impact strongly the function of all cells,but especially of *** this review,we discuss the role of the mitochondria impairment in the development of the neurodegenerative diseases Amyotrophic Lateral Sclerosis,Parkinson s disease and Alzheimer s *** highlight how mitochondria disruption revolves around the processes that underlie the mitochondria s life cycle:fusion,fission,production of reactive oxygen species and energy *** genetic and sporadic forms of neurodegenerative diseases are unavoidably accompanied with and often caused by the dysfunction in one or more of the key mitochondrial ***,in order to get in depth insights into their health status in neurodegenerative diseases,we need to focus into innovative strategies aimed at characterizing the various mitochondrial *** techniques include Mitostress,Mitotracker,transmission electron microscopy,oxidative stress assays along with expression measurement of the proteins that maintain the mitochondrial *** will also discuss a panel of approaches aimed at mitigating the mitochondrial *** include canonical drugs,natural compounds,supplements,lifestyle interventions and innovative approaches as mitochondria transplantation and gene *** conclusion,because mitochondria are fundamental organelles necessary for virtually all the cell functions and are severely impaired in neurodegenerative diseases,it is critical to develop novel methods to measure the mitochondrial state,and novel therapeutic strategies aimed at improving their health.