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One-step approach for full-thickness skin defect reconstruction in rats using minced split-thickness skin grafts with Pelnac overlay

引用

Burns & Trauma 2019年第1期7卷 167-179页

作者： Tong Liu Chao Qiu Chi Ben Haihang Li Shihui Zhu Department of Burn Surgery Institute of BurnsThe First Affiliated HospitalNaval Medical UniversityShanghai 200433China Emergency Department The First Affiliated HospitalNaval Medical UniversityShanghai 200433China

Background:Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin ***,for patients with extensive burns,split-thickness skin grafting is limited by donor skin *** split-thickness skin minced into micrografts increases the expansion ratio but may reduce wound repair *** substitutes such as Pelnac can enhance the healing of full-thickness skin wounds,but their application currently requires two *** present study investigated whether it is possible to repair full-thickness skin defects and improve wound healing quality in a single surgery using Pelnac as an overlay of minced split-thickness skin grafts in a rat ***:A full-thickness skin defect model was established using male Sprague-Dawley rats of 10 weeks *** animals were randomly divided into control and experimental groups in which Vaseline gauze and Pelnac,respectively,were overlaid on minced split-thickness skin grafts to repair the *** healing rate and quality were compared between the two *** better illustration of the quality of wound healing,some results were compared with those obtained for normal skin of ***:We found that using Pelnac as an overlay for minced split-thickness skin grafts accelerated wound closure and stimulated cell proliferation and tissue *** addition,this approach enhanced collagen synthesis and increased the formation of basement membrane and dermis as well as the expression of growth factors related to wound healing while reducing scar ***:Using minced split-thickness skin grafts overlaid with Pelnac enables the reconstruction of fullthickness skin defects in a single step and can increase the healing rate while improving the quality of wound healing.

关键词： skin wound healing Full-thickness skin defect minced skin graft Pelnac Split-thickness skin grafts Reconstruction

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