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Monopolar capacitive coupled Radiofrequency (mcRF) and ultrasound-guided Platelet Rich Plasma (PRP) give similar results in the treatment of enthesopathies: 18-Month follow-up

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Health 2013年第6期5卷 72-77页

作者： Joseph Cronkey Diana Villegas 7700 Edgewater Dr. Suite 405 Oakland CA USA

Introduction: Emergent technologies, i.e., monopolar capacitive coupled Radiofrequency (mcRF) and Platelet Rich Plasma (PRP) are now available to treat conditions characterized by a failed Wound Healing Response. Both mcRF and PRP positively influence the chemical/cellular inflammatory cascade to promote healing. mcRF application results in temperature elevation at the targeted structure up to 50℃ stimulating heat shock proteins, thus inciting the Wound Healing Response. Ultrasound-guided PRP injections results in an inflammatory/reparative reaction through cytokinin release. Methods: Sixty-eight patients who have failed previous conservative treatment for tendinopathies and chronic ligament conditions of the elbow, hip, knee and ankle/foot, were treated either with mcRF or PRP. Treatments were delivered directly by the investigator, and patients were followed prospectively for an average of 19.7 months (range 15 to 24 months). Results: Average age for the mcRF cohort was 53 years (range 17 to 88). Average age for the PRP group was 58 (range 19 to 90). The male to female ratio for both groups was 1/1. 33 of 42 patients treated with mcRF experienced marked improvement (78%), while in the PRP group 19 of 26 patients experienced marked improvement (73%) as self-assessed by study subjects. Discussion/Conclusion: Results of this study are in agreement with reports on the use of both technologies;however, this is the first time that a side-by-side comparison is established. PRP and mcRF represent a new approach to musculoskeletal pathology;both modalities aim at inducing a biological response and are considered at the frontier of regenerative therapeutics. The high safety profile suggests that these, non-invasive (mcRF) and minimally invasive (PRP), office-based alternatives for the management of musculoskeletal conditions are valuable tools and should be used in accordance with a clear understanding of the underlying pathology.

关键词： Heat-Shock RelēF Tendinosis Wound Healing Response (WHR) Tendinopathy microtenotomy Antinociceptive Thermal Field

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Mechanisms of Action of Noninvasive Monopolar Radiofrequency: Technology Review

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Open Journal of Orthopedics 2013年第1期3卷 23-28页

作者： Terry L. Whipple Scott P. Steinmann Department of Orthopaedics Mayo Clinic Rochester USA. Orthopaedic Research of Virginia Richmond USA

Tendinosis is now understood as the result of a failed tendon healing process regardless of where it occurs in the body. Current noninvasive therapeutic alternatives are anti-inflammatory in nature and outcomes are unpredictable at best. The benefit of invasive alternatives resides in the induction of the healing response as demonstrated in pre-clinical and clinical studies in cardiology and orthopaedics. A new technology that employs noninvasivemonopolar capacitive-coupled radiofrequency (mcRF), has demonstrated the ability to raise temperatures in tendons and ligaments upwards of 50°C, the temperature threshold for collagen modulation and recruitment of macrophages, fibroblasts and Heat Shock Protein factors—without damaging the overlying structures—resulting in activation of the Wound Healing Response (WHR).

关键词： Thermal Shrinkage Thermoplasty Heat-Shock AT2 Radiofrequency Collagen Denaturation Tendinosis Wound Healing Response Tendinopathy microtenotomy Antinociceptive

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