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In situ generation of biodegradable poly(p-dioxanone)microparticles by polymerization in supercritical carbon dioxide

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Chinese Chemical Letters 2011年第12期22卷 1509-1512页

作者： Tian Qiang Wang Xiu Li Zhao Jian Yuan Hao State Key Lab of Electronic Films and Integrated Devices School of Microelectronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China Institute of Chemical Materials China Academy of Engineering Physics Mianyang 621900 China

Ring-opening suspension polymerization of p-dioxanone（PDO） in supercritical carbon dioxide（scCO_2） was investigated in the presence of poly（caprolactone）-perfluropolyether-poly（caprolactone）（PCL-PFPE-PCL）.The molecular weight,yield and particle morphology of poly（p-dioxanone）（PPDO） were *** stabilizer was effective to stabilize the ring-opening polymerization（ROP） of PDO in scCO_2,leading to the formation of resorbable microparticles in a＂one pot＂*** mean size of PPDO microparticles obtained from suspension polymerizations was sensitive to the rate of agitation and the stabilizer *** method to generate PPDO microparticles has overcome its unprocessable drawback with common organic solvents and provided new product form for biomedical applications.

关键词： Biodegradable Poly(p-dioxanone) Polymerization Stabilizer microparticle

Microfluidic electrospray photo-crosslinkable κ-Carrageenan microparticles for wound healing

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Engineered Regeneration 2021年第1期2卷 257-262页

作者： Zhiqiang Luo Junyi Che Lingyu Sun Lei Yang Yan Zu Huan Wang Yuanjin Zhao Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjing 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory Zhejiang Lab for Regenerative MedicineVision and Brain HealthWenzhouZhejiang 325001China Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325001China The Eighth Affiliated Hospital Sun Yat-sen UniversityShenzhen 518033China

When organs,especially external organs are injured,pathogens and excessive water loss can threaten the wound healing process and cause local irreversible tissue ***,novel natural κ-Carrageenan microparticles(MPs)able to deliver bioactive proteins and small molecules to the wound surface for promoted regeneration were developed using microfluidic *** side chains of κ-Carrageenan were modified with methacrylate pendant groups to make the monomer photonic *** changing the concentration of methacrylated-κ-Carrageenan,different porosities of MPs with controllable drug loading were *** size of the MPs can also be tailored by adjusting the voltage of the applied electric *** endothelial growth factor(VEGF)and antimicrobial peptides Eumenitin were co-loaded into the microparticles(VEGF-Eumenitin-MPs)and released sustainedly in phosphate-buffered *** VEGF-Eumenitin-MPs had high biocompatibility and intensive antibacterial activities for ***,the antibacterial and angiogenetic properties of the VEGF-Eumenitin-MPs were demonstrated in a infectious wound model and the chronic wound healing process was significantly enhanced in ***,the developed porous MPs with sustained drug release properties have the potential to serve as a platform to deliver bioactive proteins and small molecules to the wound surface for promoted regeneration.

关键词： microparticle Hydrogel Microfluidics Wound healing VEGF Antimicrobial peptide

Emerging hemostatic materials for non-compressible hemorrhage control

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National Science Review 2022年第11期9卷 223-239页

作者： Ruonan Dong Hualei Zhang Baolin Guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology Xi'an Jiaotong University Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University

Non-compressible hemorrhage control is a big challenge in both civilian life and the battlefield, causing a majority of deaths among all traumatic injury mortalities. Unexpected non-compressible bleeding not only happens in pre-hospital situations but also leads to a high risk of death during surgical processes throughout in-hospital treatment. Hemostatic materials for pre-hospital treatment or surgical procedures for non-compressible hemorrhage control have drawn more and more attention in recent years and several commercialized products have been developed. However, these products have all shown non-negligible limitations and researchers are focusing on developing more effective hemostatic materials for non-compressible hemorrhage control. Different hemostatic strategies(physical, chemical and biological)have been proposed and different forms(sponges/foams, sealants/adhesives, microparticles/powders and platelet mimics) of hemostatic materials have been developed based on these strategies. A summary of the requirements, state-of-the-art studies and commercial products of non-compressible hemorrhage-control materials is provided in this review with particular attention on the advantages and limitations of their emerging forms, to give a clear understanding of the progress that has been made in this area and the promising directions for future generations.

关键词： non-compressible hemorrhage control commercialized hemorrhage-control strategies hemostatic sponge hydrogel microparticle platelet mimics

A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization

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药学学报:英文版 2023年第7期13卷 3168-3176页

作者： Letian Li Jiayi Hao Yuhang Jiang Pengfei Hao Yuwei Gao Jing Chen Guoqing Zhang Ningyi Jin Maopeng Wang Chang Li Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses Chinese Academy of Medical SciencesChangchun Veterinary Research InstituteChinese Academy of Agricultural SciencesChangchun 130122China Wenzhou Key Laboratory for Virology and Immunology Institute of VirologyWenzhou UniversityWenzhou 325035China

COVID-19 has globally spread to burden the medical *** with a massive vaccination,a mucosal vaccine offering more comprehensive and convenient protection is ***,a micro-sized vaccine based on recombinant Lactiplantibacillus plantarum(rLP)displaying spike or receptor-binding domain(RBD)was characterized as microparticles,and its safety and protective effects against SARS-CoV-2 were *** found a 66.7%mortality reduction and 100%protection with rLP against SARS-CoV-2 in a mouse *** histological analysis showed decreased hemorrhage symptoms and increased leukocyte infiltration in the ***,rLP:RBD significantly decreased pulmonary viral *** the first time,our study provides a ***-vectored vaccine to prevent COVID-19 progress and transmission via intranasal vaccination.

关键词： COVID-19 Mucosal vaccines Lactiplantibacillus plantarum microparticle Intranasal administration Viral challenge Mice Lung targeting delivery system

Microfluidic Generation of Multicomponent Soft Biomaterials

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Engineering 2022年第6期8卷 128-143页

作者： Yuetong Wang Luoran Shang Yuanjin Zhao Lingyun Sun Department of Rheumatology and Immunology Nanjing Drum Tower Hospital&School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210046China Shanghai Xuhui Central Hospital&Zhongshan-Xuhui Hospital&Shanghai Key Laboratory of Medical Epigenetics&International Co-Laboratory of Medical Epigenetics and Metabolism of Ministry of Science and Technology Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)&Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

Soft biomaterials hold great potential for a plethora of biomedical applications because of their deforma-bility,biodegradability,biocompatibility,high bioactivity,and low *** soft bio-materials are particularly attractive as a way of accommodating components made of different materials and generating combinative *** technology has emerged as an outstanding tool in generating multicomponent materials with elaborate structures and constituents,in that it can manipu-late multiphasic flows precisely on the micron *** recent decades,much progress has been achieved in the microfluidic fabrication of multicomponent soft biomaterials with finely defined physicochemical properties capable of controllable therapeutics delivery,three-dimensional(3D)cell culture,flexible devices and wearable electronics,and biosensing for *** the paper,we summarize current pro-gress in multicomponent soft biomaterials derived from microfluidics and emphasize their applications in biomedical *** also provide an outlook of the remaining challenges and future trends in this field.

关键词： Soft biomaterial Microfluidics Multicomponent microparticle Microfiber

表面基于 homolipids 和 Softisan 修改了稳固的类脂化合物 microparticles ?142: 初步的描述

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Asian Pacific Journal of Tropical Medicine 2010年第3期3卷 205-210页

作者： Nnamani PO Ibezim EC Attama AA Adikwu MU Drug Delivery Research Unit Department of PharmaceuticsFaculty of Pharmaceutical SciencesUniversity of Nigeria ICS-UNIDO International Center for High Technology and New Materials AREA Science Park Science and Technology Education Post-Basic(STEP-B) Abuja Nigeria

Objective:To preliminarily investigate three different lipid matrices consisting of two natural homolipids from Capra hircus(goat fat) and Bovine Spp.(tallow fat) and one semi-synthetic lipid(Softisan~? 142) separately structured with Phospholipon~? 90G(P90G) as potential delivery systems for poorly water soluble ***:The structured lipid matrices were characterized by differential scanning calorimetry(DSC) and employed to prepare solid lipid microparticles(SLMs) by the melt homogenization method using gradient concentrations of polysorbate 80 and at different emulsification times of 2,5 and 10 min using a Silverson mixer. The SLMs were analyzed for morphology and particle size,thermal properties,stability studies and determination of ***:The results showed that SLM production was optimum at 5%of lipid matrices,1.5%of polysorbate 80 and emulsification time of 5 *** in polysorbate 80 concentrations decreased the particle size of the *** SLMs were well formed, spherical,smooth and non-porous with particle sizes in the ranges of(13.90±2.10)μm -(0.09±0.01)μm for SLMs produced from the structured - tallow fat;(13.40±1.30)μm-(0.10±0.01)μm for the structured - goat fat and(13.40±2.00)μm-(2.10±1.00)μm for the structured Softisan~? 142 lipid *** traces showed that Softisan~? 142 was the most crystalline of all three bulk matrices due to its high enthalpy(-7.962 mW/mg) while tallow fat was the least(-5.067 mW/mg) but addition of P90G to the matrices lowered their enthalpies mostly in the structured goat fat *** SLMs when stored at 4-6°C were most stable and syringeable with 27 G ***:This suggests that structured goat fat matrices with the enthalpy of -2.813 mW/mg will mosdy favour drug loading of some poorly soluble drugs more than tallow fat(-4.892 mW/mg) and Softisan? 142(-5.501 mW/mg).

关键词： Phospholipon 90G Solid lipid microparticle Goat fat Tallow fat Softisan 142 Characterization

One-Step Preparation of Poly-Lactic-Co-Glycolic-Acid microparticles to Prevent the Initial Burst Release of Encapsulated Water-Soluble Proteins

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Pharmacology & Pharmacy 2013年第8期4卷 578-583页

作者： Hiroyuki Takabe Moriyuki Ohkuma Yasunori Iwao Shuji Noguchi Shigeru Itai Department of Pharmaceutical Engineering Graduate School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Drug Formulation Department Central Research Laboratories Kaken Pharmaceutical Co. Ltd. Shizuoka Japan Drug Formulation Department Central Research Laboratories Kaken Pharmaceutical Co. Ltd. Shizuoka Japan Department of Pharmaceutical Engineering Graduate School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan.

An initial burst is often observed during the release of active pharmaceutical ingredients (APIs) from poly-lactic-coglycolic-acid (PLGA) microparticles (MPs) which have been prepared by the emulsion-solvent evaporation method. Herein, we describe the development of a simple one-step coating method that suppresses the initial burst release process. This new method involves coating the PLGA-MPs with PLGA, with the coating process being performed through the phase separation of PLGA on the surface of PLGA-MPs using the emulsion-solvent evaporation method. Bovine serum albumin (BSA) was encapsulated in the PLGA-MPs as a model API. The coated MPs were spherical in shape with no pores on their smooth surface, whereas the non-coated PLGA-MPs had porous surfaces. An in vitro release study showed that the residual levels of BSA in the coated and non-coated PLGA-MPs after 1 h were about 99% and 16% of the original loads, respectively. The one-step coating method therefore represents a useful method for preparing PLGA-MPs that do not give an initial burst release of proteinaceous APIs.

关键词： Poly-Lactic-Co-Glycolic-Acid microparticle Suppression of Initial Burst Release Coating Bovine Serum Albumin

Preparation of Hollow Calcium Silicate microparticles by Simple Emulsion

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Journal of Encapsulation and Adsorption Sciences 2014年第4期4卷 114-121页

作者： Eiichi Toorisaka Syotaro Nagamatsu Yasunobu Saruwatari Makoto Hirata Tadashi Hano Department of Environmental Science and Engineering Yamaguchi University Yamaguchi Japan Department of Applied Chemistry Oita University Oita Japan

Hollow calcium silicate microparticles were prepared by mixing a water-in-oil (W/O) emulsion containing silicate ions in aqueous phase with an oil phase containing a calcium/di-2-ethylhexyl phosphoric acid (D2EHPA) complex. The inorganic precipitation reaction at the oil-water interface was accelerated by using a simple W/O emulsion. Hollow microparticles were obtained when the mole ratio of D2EHPA and calcium in the oil phase was nearly 2:1. The shell formation of the par-ticles depended on the acceleration of the precipitation reaction, which could be accomplished by controlling the concentrations of the calcium and silicate ions.

关键词： Hollow Inorganic microparticle Water-in-Oil Emulsion Solvent Extraction Interfacial Reaction

Pharmacokinetic Evaluation of Chitosan-Succinyl-Prednisolone Conjugate microparticles as a Colonic Delivery System: Comparison with Enteric-Coated Conjugate microparticles

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Health 2014年第11期6卷 1286-1295页

作者： Hiraku Onishi Department of Drug Delivery Research Hoshi University Tokyo Japan

In the previous study, chitosan-succinyl-prednisolone conjugate microparticles (MP) were found to exhibit good efficacy and reduced toxicity nearly as well as their Eudragit L-coated microparticles (MP/EuL). This proposes a question whether enteric-coating of MP is necessary or not. Although MP/EuL were already examined for their pharmacokinetic and gastrointestinal behaviors, MP have not been done yet. Therefore, in this study, MP were evaluated by investigating pharmacokinetic features in detail. MP with the in vitro features equivalent to those of the previous conjugate microparticles could be produced more readily in the modified preparative method. Pharmacokinetic and gastrointestinal behaviors of MP were investigated by intragastric dosing (5 mg PD eq./kg) to rats with 2,4,6-trinitrobenzenesulfonic acid-induced ulcerative colitis. The plasma concentration was suppressed extensively in MP as well as MP/EuL, supporting the reduction of PD systemic toxic side effects. However, the plasma level increased gradually up to 7 h in MP, but not in MP/EuL. At 8 h after dosing, MP were detected in the stomach to a fair extent, and free PD was found there, indicating that MP were subjected to trapping in the stomach probably due to positive charge of chitosan molecules. For MP, such prolonged localization and slow release of PD in the stomach were probably associated with the gradual increase in plasma concentration. Therefore, MP/EuL were evaluated to be superior to MP for effective targeting to ulcerative colitis. It is concluded that enteric-coating is very important for the targeting system using MP.

关键词： Chitosan-Succinyl-Prednisolone Conjugate microparticle Enteric-Coating Pharmacokinetic Feature Gastrointestinal Behavior 2 4 6-Trinitrobenzenesulfonic Acid-Induced Ulcerative Colitis