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Primary aldosteronism due to bilateral micronodular hyperplasia and concomitant subclinical Cushing’s syndrome:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1119-1126页

作者： Hiroki Teragawa Chikage Oshita Yuichi Orita Kunihiro Hashimoto Hirofumi Nakayama Yuto Yamazaki Hironobu Sasano Department of Cardiovascular Medicine JR Hiroshima HospitalHiroshima 732-0057Japan Department of Urology JR Hiroshima HospitalHiroshima 732-0057Japan Department of Pathology and Laboratory Medicine JR Hiroshima HospitalHiroshima 732-0057Japan Department of Pathology Tohoku University Graduate School of MedicineSendai 980-8574Japan

BACKGROUND Adrenal incidentaloma(AI)has been frequently encountered in the clinical *** has been shown that primary aldosteronism(PA)or subclinical Cushing’s syndrome(SCS)are the representative causative diseases of ***,the coexistence of PA and SCS has been reportedly ***,we encountered a case of AI,in which PA and SCS coexisted,confirmed by histopathological examinations after a laparoscopic *** believe that there were some clinical implications in the diagnosis of the present *** SUMMARY A 58-year-old man presented with lower right abdominal pain with a blood pressure of 170/100 mmHg.A subsequent computed tomography scan revealed right ureterolithiasis,which was the cause of right abdominal pain,and right AI measuring 22 mm×25 *** the disappearance of right abdominal pain,subsequent endocrinological examinations were ***-related evaluations,including adrenal venous sampling,revealed the presence of bilateral *** addition,several cortisol-related evaluations showed the presence of SCS on the right adrenal adenoma.A laparoscopic right adrenalectomy was then *** histopathological examination of the resected right adrenal revealed the presence of a cortisol-producing adenoma,while CYP11B2 immunoreactivity was absent in this ***,in the adjacent nonneoplastic adrenal,multiple CYP11B2-positive adrenocortical micronodules were detected,showing the presence of aldosterone-producing adrenocortical *** Careful clinical and pathological examination should be performed when a patient harboring AI presents with concomitant SCS and PA.

关键词： Primary aldosteronism Subclinical Cushing’s syndrome Adrenal incidentaloma micronodular hyperplasia Case report

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