Primary aldosteronism due to bilateral micronodular hyperplasia and concomitant subclinical Cushing’s syndrome:A case report

作     者：Hiroki Teragawa Chikage Oshita Yuichi Orita Kunihiro Hashimoto Hirofumi Nakayama Yuto Yamazaki Hironobu Sasano 

作者机构：Department of Cardiovascular MedicineJR Hiroshima HospitalHiroshima 732-0057Japan Department of UrologyJR Hiroshima HospitalHiroshima 732-0057Japan Department of Pathology and Laboratory MedicineJR Hiroshima HospitalHiroshima 732-0057Japan Department of PathologyTohoku University Graduate School of MedicineSendai 980-8574Japan 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第5期

页      面：1119-1126页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Japan Society for the Promotion of Science  JSPS  (19K17974) 

主　　题：Primary aldosteronism Subclinical Cushing’s syndrome Adrenal incidentaloma Micronodular hyperplasia Case report 

摘      要：BACKGROUND Adrenal incidentaloma(AI)has been frequently encountered in the clinical *** has been shown that primary aldosteronism(PA)or subclinical Cushing’s syndrome(SCS)are the representative causative diseases of ***,the coexistence of PA and SCS has been reportedly ***,we encountered a case of AI,in which PA and SCS coexisted,confirmed by histopathological examinations after a laparoscopic *** believe that there were some clinical implications in the diagnosis of the present *** SUMMARY A 58-year-old man presented with lower right abdominal pain with a blood pressure of 170/100 mmHg.A subsequent computed tomography scan revealed right ureterolithiasis,which was the cause of right abdominal pain,and right AI measuring 22 mm×25 *** the disappearance of right abdominal pain,subsequent endocrinological examinations were ***-related evaluations,including adrenal venous sampling,revealed the presence of bilateral *** addition,several cortisol-related evaluations showed the presence of SCS on the right adrenal adenoma.A laparoscopic right adrenalectomy was then *** histopathological examination of the resected right adrenal revealed the presence of a cortisol-producing adenoma,while CYP11B2 immunoreactivity was absent in this ***,in the adjacent nonneoplastic adrenal,multiple CYP11B2-positive adrenocortical micronodules were detected,showing the presence of aldosterone-producing adrenocortical *** Careful clinical and pathological examination should be performed when a patient harboring AI presents with concomitant SCS and PA.