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A novel microcurrent dressing for wound healing in a rat skin defect model

Military Medical Research 2020年第2期7卷 190-198页

作者： Chao Yu Zhi-Xiu Xu Yan-Hui Hao Ya-Bing Gao Bin-Wei Yao Jing Zhang Bing Wang Zong-Qian Hu RuiYun Peng Department of Experimental Pathology Beijing Institute of Radiation MedicineBeijing 100850China department of Internal Neurology The First Affiliated Hospital/Xinxiang Medical UniversityXinxiang 453100HenanChina department of Biotechnology Beijing Institute of Radiation MedicineBeijing 100850China

Background:The exogenous application of low-intensity electric stimulation(ES)may mimic a natural endogenous bioelectric current and accelerate the repair process of skin *** study designed a novel microcurrent dressing(MCD)and evaluated its potential effects on wound healing in a rat skin defect ***:First,wireless ES was integrated into a medical cotton cushion to fabricate the MCD,and its electrical property was examined by using a universal power ***,animal experiments were conducted to evaluate the MCD’s ***-five rats were randomized into control(Con)group,Vaseline gauze(VG)group and MCD group.A full-thickness round skin incision 1.5 cm in diameter was made on the back of each *** from routine disinfection,the Con rats were untreated,whereas the other two groups were treated with VG or *** days 3,7 and 14 post injury,the wound areas were observed and measured using image analysis software following photography,and the skin samples were harvested from wound ***,histopathological morphology was observed routinely by hematoxylin and eosin(HE)staining;tumor necrosis factorα(TNF-α)and interleukin(IL)-1βexpression were detected by Western *** endothelial growth factor(VEGF)and epidermal growth factor(EGF)expression were detected with ***:The MCD generated a sf electric potential greater than 0.95 *** experiments showed that the woundhealing rate in the MCD group was significantly increased compared with the Con and VG groups(P<0.05 or P<0.01).Histopathological observation revealed an alleviated inflammatory response,induced vascular proliferation and accelerated epithelization in the MCD ***,samples from the MCD group expressed reduced TNF-αand IL-1βlevels and increased VEGF and EGF levels compared with those of the other two groups(P<0.05 or P<0.01).However,no significant difference was noted between the Con and VG groups at each time ***:The MCD

关键词： microcurrent dressing Electric stimulation Skin Wound healing

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