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microfluidics-based strategies for molecular diagnostics of infectious diseases

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Military Medical Research 2022年第6期9卷 727-753页

作者： Xin Wang Xian-Zhe Hong Yi-Wei Li Ying Li Jie Wang Peng Chen Bi-Feng Liu The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics&Molecular Imaging Key Laboratory Systems Biology ThemeDepartment of Biomedical EngineeringCollegeof Life Science and TechnologyHuazhong University of Scienceand TechnologyWuhan 430074China State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics Wuhan National Laboratory for OptoelectronicsNational Centre for Magnetic Resonancein WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430071China Department of Radiology Canary Center at Stanford for Cancer Early DetectionSchool of MedicineStanford UniversityPalo AltoCA 94304USA

Traditional diagnostic strategies for infectious disease detection require benchtop instruments that are inappropriate for point-of-care testing(POCT). Emerging microfluidics, a highly miniaturized, automatic, and integrated technology,are a potential substitute for traditional methods in performing rapid, low-cost, accurate, and on-site *** diagnostics are widely used in microfluidic devices as the most effective approaches for pathogen *** review summarizes the latest advances in microfluidics-based molecular diagnostics for infectious diseases from academic perspectives and industrial outlooks. First, we introduce the typical on-chip nucleic acid processes,including sample preprocessing, amplification, and signal read-out. Then, four categories of microfluidic platforms are compared with respect to features, merits, and demerits. We further discuss application of the digital assay in absolute nucleic acid quantification. Both the classic and recent microfluidics-based commercial molecular diagnostic devices are summarized as proof of the current market status. Finally, we propose future directions for microfluidics-based infectious disease diagnosis.

关键词： microfluidics Molecular diagnostics Infectious disease Point-of-care testing(POCT) Digital assay

microfluidics-based technologies for the analysis of extracellular vesicles at the single-cell level and single-vesicle level

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Chinese Chemical Letters 2022年第6期33卷 2893-2900页

作者： Fengjiao Zhu Yahui Ji Jiu Deng Linmei Li Xue Bai Xianming Liu Bingcheng Lin Yao Lu Department of Biotechnology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

Extracellular vesicles(EVs)are membrane vesicles secreted by cells,playing critical roles in mediating intercellular communications for various physiological and pathological *** of the EV analysis is currently performed at the bulk level,obscuring the origin of the EVs and diverse characteristics of the individual extracellular *** to analyze the extracellular vesicles at the single-cell and single-vesicle levels are needed to evaluate EV comprehensively and decode the heterogeneity underlying EV *** platforms that could control and manipulate fluids at the microscale provide an efficient way to achieve the *** microfluidics-based technologies are emerging to realize single-cell EV secretion analysis and single EV analysis,which would be summarized in this mini-review.

关键词： microfluidics Single-cell EV analysis Single EV analysis Extracellular vesicle Heterogeneity

microfluidics for Medical Additive Manufacturing

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Engineering 2020年第11期6卷 1244-1257页

作者： Jie Wang Changmin Shao Yuetong Wang Lingyun Sun Yuanjin Zhao Department of Rheumatology and Immunology.Institute of Translational Medicine The Afliated Drum Tower Hospital of Nonjing University Medical SchoolNanjing 210008China College of Artificial Intelligence Nanjing Agricultural UniversityNanjing 210031China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Additive manufacturing plays a vital role in the food,mechanical,pharmaceutical,and medical *** these fields,medical additive manufacturing has led to especially obvious improvements in medical instruments,prostheses,implants,and so forth,based on the advantages of cost-effectiveness,customizability,and quick *** the features of precise structural control,high throughput,and good component manipulation,microfluidic techniques present distinctive benefits in medical additive manufacturing and have been applied in the areas of drug discovery,tissue engineering,and organs on ***,a comprehensive review of microfluidic techniques for medical additive manufacturing is useful for scientists with various ***,we review recent progress in the development of microfluidic techniques for medical additive *** evaluate the distinctive benefits associated with microfluidic technologies for medical additive manufacturing with respect to the fabrication of droplet/fiber templates with different *** applications of microfluidic techniques for medical additive manufacturing are emphasized,such as cell guidance,three-dimensional(3D)cell culture,tissue assembly,and cell-based ***,we present challenges in and future perspectives on the development of microfluidics for medical additive manufacturing.

关键词： microfluidics Biomaterial Additive manufacturing Droplet Fiber

microfluidics embedded with microelectrodes for electrostimulation of neural stem cells proliferation

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Chinese Chemical Letters 2022年第3期33卷 1308-1312页

作者： Qian Li Bodong Kang Libin Wang Tao Chen Yu Zhao Shilun Feng Rongjing Li Hongtian Zhang Institute of Advanced Photonics Technology Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Trans-scale Laser Manufacturing Technology(Beijing University of Technology) Ministry of EducationBeijing 100124China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Department of Neurosurgery The 7th Medical CenterGeneral Hospital of the Chinese People's Liberation ArmyBeijing 100700China

The regeneration of the injured nerve and recovery of its function have brought attention in the medical field. Electrical stimulation(ES) can enhance the cellular biological behavior and has been widely studied in the treatment of neurological diseases. Microfluidic technology can provide a cell culture platform with the well-controlled environment. Here a novel microfluidic/microelectrode composite microdevice was developed by embedding the microelectrodes to the microfluidic platform, in which microfluidics provided a controlled cell culture platform, and ES promoted the NSCs proliferation. We performed ES on rat neural stem cells(NSCs) to observe the effect on their growth, differentiation, proliferation, and preliminary explored the ES influence on cells in vitro. The results of immunofluorescence showed that ES had no significant effect on the NSCs specific expression, and the NSCs specific expression reached 98.9%± 0.4% after three days of ES. In addition, ES significantly promoted cell growth and the cell proliferation rate reached 49.41%. To conclude, the microfluidic/microelectrode composite microdevice can play a positive role in the nerve injury repair and fundamental research of neurological diseases.

关键词： microfluidics Microelectrode Electrical stimulation NSCs Proliferation

microfluidics-derived microfibers in flexible bioelectronics

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Materials Futures 2024年第3期3卷 54-70页

作者： Chaoyu Yang Xingyu Hou Li Zhang Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatinN.T.Hong Kong Special Administrative Region of China 999077People’s Republic of China

Flexible electronics have attracted extensive attention across a wide range of fields due to their potential for preventive medicine and early disease ***-based textiles,encountered in everyday life,have emerged as promising platforms with integrated sensing *** technology has been recognized as a promising avenue for the development of flexible conductive microfibers and has made significant *** this review,we provide a comprehensive overview of the state-of-the-art advancements in microfiber-based flexible electronics fabricated using microfluidic ***,the fundamental strategies of the microfluidic fabrication of conductive microfibers with different structures and morphologies are ***,attention is then directed towards the diverse applications of these microfibers in ***,we offer a forwardlooking perspective on the future challenges about microfluidic-derived microfibers in flexible bioelectronics.

关键词： microfluidics conductive microfibers sensing flexible bioelectronics

microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture

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Bioactive Materials 2022年第6期7卷 133-142页

作者： Xingjie Yin Jingli Ren Wei Lan Yu Chen Mengping Ouyang Hua Su Lianbin Zhang Jintao Zhu Chun Zhang Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan430022China Key Lab of Material Chemistry for Energy Conversion and Storage of Ministry of Education School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Coal Combustion and School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China

Although common in clinical practice,bleeding after tissue puncture may cause serious outcomes,especially in arterial ***,gelatin-tannic acid composite hydrogels with varying compositions are prepared,and their adhesive properties are further optimized in microfluidic channel-based simulated vessels for haemostasis in arterial *** is revealed that the composite hydrogels on the syringe needles used for arterial puncture should possess underwater adhesion higher than 4.9 kPa and mechanical strength higher than 86.0 *** needles coated with the gelatin-tannic acid composite hydrogel completely prevent blood loss after both vein and arterial puncture in different animal *** study holds great significance for the preparation of haemostatic needles for vessel puncture,and gelatin-tannic acid hydrogel coated needles may help to prevent complications associated with arterial puncture.

关键词： Gelatin hydrogel Underwater adhesive microfluidics Haemostatic coating Vessel puncture

Process intensification for the synthesis and purification of battery-grade Li_(2)CO_(3)with microfluidics

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Particuology 2024年第7期90卷 106-117页

作者： Haodu Li Jie Zhang Lin Dai Le Du Jiqin Zhu The State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Battery-grade lithium carbonate(Li_(2)CO_(3))with a purity of higher than 99.5 wt%is of great importance as a high value-added lithium ***,influences of different reaction systems and process control on product purity remain ***,a membrane dispersion microreactor was used to enhance the mass transfer of preparation and purification processes in homogeneous and heterogeneous *** systems of Na_(2)CO_(3)–LiCl,NH_(4)HCO_(3)–LiCl,and NH_(3)·H_(2)O−CO_(2)−LiCl,CO_(2)purification based on carbonation and decomposition were *** Li_(2)CO_(3)purity was increased by the improvement of mixing *** carbonation time was reduced by 62.5%and 58.3%for the NH_(3)·H_(2)O−CO_(2)and CO_(2)purification systems,*** the two ammonia-based systems,Li_(2)CO_(3)particles with a purity of 99.7–99.8 wt%were one-step prepared with a size of 3–5μm,which also met the requirement of the battery-grade *** purity was further increased to 99.9 wt%by CO_(2)purification and LiHCO_(3)*** investigation could provide a feasible alternative for the controllable preparation of battery-grade Li_(2)CO_(3)in one or multiple steps.

关键词： microfluidics Battery grade Li_(2)CO_(3) Process intensification High purity

Surface-tension-confined droplet microfluidics

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Chinese Physics B 2018年第2期27卷 29-42页

作者：陈新莲伍罕巫金波 Materials Genome Institute Shanghai University College of Science Shanghai University

This article is a concise overview about the developing microfluidic systems named surface-tension-confined droplet microfluidics （STORMs）. Different from traditional complexed droplet microfluidics which generated and confined the droplets by three-dimensional （3D） poly（dimethylsiloxane）-based microchannels, STORM systems provide two- dimensional （2D） platforms for control of droplets. STORM devices utilize surface energy, with methods such as surface chemical modification and mechanical processing, to control the movement of fluid droplets. Various STORM devices have been readily prepared, with distinct advantages over conventional droplet microfluidics, which generated and confined the droplets by 3D poly（dimethylsiloxane）-based microchannels, such as significant reduction of energy consumption neces- sary for device operation, facile or even direct introduction of droplets onto patterned surface without external driving force such as a micropump, thus increased frequency or efficiency of droplets generation of specific STORM device, among others. Thus, STORM devices can be excellent alternatives for majority areas in droplet microfluidics and irreplaceable choices in certain fields by contrast. In this review, fabrication methods or strategies, manipulation methods or mechanisms, and main applications of STORM devices are introduced.

关键词： surface-tension-confined droplet microfluidics micropatterning wettability

Micro-nano-fabrication of green functional materials by multiphase microfluidics for environmental and energy applications

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Green Energy & Environment 2024年第8期9卷 1199-1219页

作者： Cheng Qi Tao Zhou Xingjiang Wu Kailang Liu Lei Li Zhou Liu Zhuo Chen Jianhong Xu Tiantian Kong Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhenGuangdong518000China The State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing100084China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenGuangdong518000China Department of Biomedical Engineering School of MedicineShenzhen UniversityShenzhenGuangdong518000China

Multiphase microfluidic has emerged as a powerful platform to produce novel materials with tailor-designed functionalities,as microfluidic fabrication provides precise controls over the size,component,and structure of resultant ***,functional materials with well-defined micro-/nanostructures fabricated by microfluidics find important applications as environmental and energy *** review first illustrated in detail how different structures or shapes of droplet and jet templates are formed by typical configurations of microfluidic channel networks and multiphase flow ***,recent progresses on several representative energy and environmental applications,such as water purification,water collecting and energy storage,were ***,it is envisioned that integrating microfluidics and other novel materials will play increasing important role in contributing environmental remediation and energy storage in near future.

关键词： microfluidics Multi-phase flow Droplet and microfiber Environmental remediation Energy Storage