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Journal of Environmental Sciences 2013年第5期25卷 882-888页

作者： Thabitha P.Dasari Kavitha Pathakoti Huey-Min Hwang Environmental Science Ph.D.Program Jackson State UniversityJacksonMS 39217USA Department of Biology Jackson State UniversityJacksonMS 39217USA

Cytotoxicity of selected metal oxide nanoparticles（MNPs）（ZnO,CuO,Co 3 O 4 and TiO 2）was investigated in Escherichia coli both under light and dark *** experiments were conducted with spread plate counting and the LC 50 values were *** determined the mechanism of toxicity via measurements of oxidative stress,reduced glutathione,lipid peroxidation,and metal *** overall ranking of the LC 50 values was in the order of ZnO 〈 CuO 〈 Co 3 O 4 〈 TiO 2 under dark condition and ZnO 〈 CuO 〈 TiO 2 〈 Co 3 O 4 under light *** MNPs were the most toxic among the tested *** results indicate depletion of reduced glutathione level and elevation of malondialdehyde level correlated with the increase in oxidative *** metal ions were found to have partial effect on the toxicity of MNPs to *** summary,the dynamic interactions of multiple mechanisms lead to the toxicity of the tested MNPs to ***.

关键词： metal oxide nanoparticles reactive oxygen species median lethal concentration reduced glutathione lipid peroxidation

Impact of metal oxide nanoparticles on cotton(Gossypium hirsutum L.):a physiological perspective

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Journal of Cotton Research 2021年第2期4卷 169-187页

作者： SINGH BRAR Ravinderdeep KUMAR Avneesh KAUR Simranjeet SAHA Sandip KUMAR Anuj KUMAR Sandeep Department of Chemistry Akal UniversityTalwandi SaboBathindaPunjab151302India Department of Botany Akal UniversityTalwandi SaboBathindaPunjab151302India Indian Agricultural Statistics Institute DelhiIndia

Cotton production substantiated a crucial part in the escalating economic development of many *** realize the increasing global demand for cotton,the emphasis should be laid on to improve cotton fiber growth and *** bioengineered transgenic cotton proved expedient in resolving inadequacies of conventional cotton,but still required improvements to encounter heightened demand of textile *** possible solution pertaining to this has been provided by nanoscience in the form of metal or metal oxide *** metal oxide nanoparticles have easy access to the various parts of cotton plants through its transportation system,and thus significantly influence several parameters relative to the growth and production of cotton *** review summarizes the distribution and accumulation of metal oxide nanoparticles in cotton plant and its impact on different plant growth-promoting factors,which resulted in the improved cotton yields.

关键词： Cotton Bt-transgenic nanoparticles metal oxide nanoparticles Phytohormones Superoxide dismutase Nutrient element

Toxic effects of metal oxide nanoparticles and their underlying mechanisms

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Science China Materials 2017年第2期60卷 93-108页

作者：王艳丽丁琳姚晨婕李晨晨邢晓军黄雅男顾天骄吴明红 Institute of Nano-chemistry and Nano-biology Shanghai University Shanghai 200444 China Harvard School of Public Health Harvard University Boston Massachusetts 02115 USA

Nanomaterials have attracted considerable interest owing to their unique physicochemical *** wide application of nanomaterials has raised many concerns about their potential risks to human health and the *** oxide nanopartides（MONPs）,one of the main members of nanomaterials,have been applied in various fields,such as food,medicine,cosmetics,and *** review highlights the bio-toxic effects of widely applied MONPs and their underlying *** main underlying toxicity mechanisms,reactive oxygen species（ROS）-and non-ROS-mediated toxidties,of MONPs have been widely *** activates oxidative stress,which leads to lipid peroxidation and cell membrane *** addition,ROS can trigger the apoptotic pathway by activating caspase-9 ***-ROS-mediated toxicity mechanism includes the effect of released ions,excessive accumulation of NPs on the cell surface,and combination of NPs with specific death ***,the combined toxicity evaluation of some MONPs is also *** may dramatically change when nanomaterials are used in a combined system because the characteristics of NPs that play a key role in their toxicity such as size,surface properties,and chemical nature in the complex system are different from the pristine NPs.

关键词： metal oxide nanoparticles bio-toxicity effect nanotoxicology underlying mechanism

Coulometric sizing of nanoparticles： Cathodic and anodic impact experiments open two independent routes to electrochemical sizing of Fez04 nanoparticles

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Nano Research 2013年第11期6卷 836-841页

作者： Kristina Tschulik Baptiste Haddou Dario Omanovi Neil V. Rees Richard G. Compton Department of Chemistry Physical & Theoretical Chemistry Laboratory Oxford University South Parks Road Oxford OXI 3QZUnited Kingdom Center for Marine and Environmental Research Ruder Boskovic Institute P. O. Box 180 I0001 Zagreb Croatia

Anodic particle coulometry （APC） is a recently established method of sizing individual metal nanoparticles by oxidising them during their impact on a micro electrode. Here it is demonstrated that the application of APC can be extended to sizing of metal oxide nanoparticles, such as Fe304 magnetite nanoparticles. Additionally, a new route to electrochemical nanoparticle sizing is introduced-- cathodic particle coulometry （CPC）. This method uses the reduction of impacting nanoparticles, e.g., metal oxide nanoparticles, and is demonstrated to yield correct size information for Fe304 nanoparticles. The combination of these two independent electrochemical methods of nanoparticle sizing, allows for purely electrochemical sizing of single nanoparticles and simultaneous verification of the obtained results.

关键词： nanoparticle sizing Fe3O4 anodic particle coulometry cathodic particle coulometry impact experiments metal oxide nanoparticles

Stable isotope labeling of nanomaterials for biosafety evaluation and drug development

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Chinese Chemical Letters 2022年第7期33卷 3303-3314页

作者： Xue-Ling Chang Lingyun Chen Boning Liu Sheng-Tao Yang Haifang Wang Aoneng Cao Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission School of Chemistry and EnvironmentSouthwest Minzu UniversityChengdu 610041China Institute of Nanochemistry and Nanobiology Shanghai UniversityShanghai 200444China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of Chinaand University of Chinese Academy of SciencesBeijing 100190China

Quantitative information,such as environmental migration,absorption,biodistribution,biotransformation,and elimination,is fundamental and essential for the nanosafety evaluations of *** to the complexity of biological and environmental systems,it is challenging to develop quantitative approaches and tools that could characterize intrinsic behaviors of nanomaterials in the *** isotopic tracers are ideal candidates to tune the physical properties of nanomaterials while preserving their chemical *** this review article,we summarized the stable isotope labeling methods of nanomaterials for evaluating their environmental and biological *** skeleton labeling protocols of carbon nanomaterials and metal/metal oxide nanoparticles were *** advantages and disadvantages of stable isotope labeling were discussed in comparison with other quantitative methods for *** quantitative information of nanomaterials in environmental and biological systems was summarized along with the biosafety *** benefits for drug development of nanomedicine were analyzed based on the targeting effects,persistent accumulation,and ***,the challenges and future perspectives of stable isotope labeling in nanoscience and nanotechnology were discussed.

关键词： Stable isotope labeling Quantification Carbon nanomaterials metal oxide nanoparticles Nanotoxicity Biomedical effects

Nanoreactors derived from silica-protection-assisted metal-organic framework

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Chinese Chemical Letters 2020年第9期31卷 2207-2210页

作者： Ling Jin Xiaxia Li Chunsen Liu Huan Pang School of Chemistry and Chemical Engineering Guangling CollegeYangzhou UniversityYangzhou 225009China Henan Provincial Key Laboratory of Surface&Interface Science Zhengzhou University of Light IndustryZhengzhou 450002China

The construction of highly stable and regular nanoreactors is a major *** this work,we use a facile template protection method to obtain ZIF-67@SiO2(JS) and to encapsulate metal oxide nanoparticles(Co3O4) into nanoreactors(SiO2).ZIF-67 crystals provide a cobalt species;SiO2 was first used as a protective layer of ZIF-67 and then as a nanoreactor for metastable metal oxide *** this basis,Co3O4@SiO2 with dodecahedron morphology were synthesized by calcining JS at different tempe ratures,followed by a hydrothermal reaction to obtain Co3(OH)***,CoSx and CoP-SiO2 were fabricated through sulfuration and *** results in this work show that nanoreactors derived from metal-organic frameworks(MOFs) with a rational structure have broad development prospects.

关键词： Core-shell structure metal oxide nanoparticles Co3(OH)4Si2O5 Nanoreactors Silicon shell

ZnO,TiO_2,SiO_2,and Al_2O_3 nanoparticles-induced Toxic Effects on Human Fetal Lung Fibroblasts

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Biomedical and Environmental Sciences 2011年第6期24卷 661-669页

作者： ZHANG Xiao Qiang YIN Li Hong TANG Meng PU Yue Pu School of Public Health Southeast University Nanjing 210009 Jiangsu China Key Laboratory of Environmental Medicine and Engineering Ministry of Education Southeast University Nanjing 210009 Jiangsu China

Objective This study aims to investigate and compare the toxic effects of four types of metal oxide （ZnO, TiO2, SiO2, and Al2O3） nanoparticles with similar primary size （-20 nm） on human fetal lung fibroblasts （HFL1） in *** The HFL1 cells were exposed to the nanoparticles, and toxic effects were analyzed by using MTT assay, cellular morphology observation and Hoechst 33 258 *** The results show that the four types of metal oxide nanoparticles lead to cellular mitochondrial dysfunction, morphological modifications and apoptosis at the concentration range of 0.25-1.50 mg/mL and the toxic effects are obviously displayed in dose-dependent manner. ZnO is the most toxic nanomaterials followed by TiO2, SiO2, and Al2O3 nanoparticles in a descending *** The results highlight the differential cytotoxicity associated with exposure to ZnO, TiO2, SiO2, and Al2O3 nanoparticles, and suggest an extreme attention to safety utilization of these nanomaterials.

关键词： metal oxide nanoparticles Toxic effects Fibroblasts

不同表面金属氧化物纳米微粒对干细胞分化行为的影响研究

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不同表面金属氧化物纳米微粒对干细胞分化行为的影响研究

作者： Surakshya Shrestha 浙江大学

学位级别：硕士

Mesenchymal stem cells （MSCs） are broadly accepted in tissue repair and regeneration for its peculiar characteristics. nanoparticles （NPs） are often used together with MSCs for multiple purposes such as tissue repair and regeneration, labelling and tracking, drug delivery and gene delivery. Moreover, the metal oxide NPs are mostly preferred for such applications due to comparatively enhanced properties. It is widely known that the cellular uptake and endocytosis of NPs can alter cell function and even affect the differentiation potential of MSCs. This impact generally depends on the NPs characteristics like their composition, size/shape, protein corona and surface chemistry. Among these parameters, the surface chemistry of NPs has significant effect on MSC differentiation, but it is not thoroughly *** the first project, two kinds of iron oxide nanoparticles with different surface chemistry, i.e. one in its pristine form （P-NPs） without extra capping molecules and the other coated with citrate （C-NPs）, with a similar size,～10 nm measured by transmission electron microscopy （TEM） were used. Both P-NPs and C-NPs aggregated to some extent in water, with hydrodynamic diameters of 211.4 ± 29 and 128.6 ± 6.3 nm, and surface zeta potential of +23.5 ± 0.3 and -49.6 ± 0.5 mV. respectively. However, both NPs further aggregated to a similar extent with hydrodynamic diameters of 260 ±5.5 and 214 ± 6.4 nm and slightly negative surface charge （～-10 mV） in cell differentiation media. On incubation of rat MSCs with NPs for 14 d, both NPs showed similar cell uptake kinetics and final intracellular iron content, and minimal cytotoxicity at a concentration below 100 μg/mL. The adipogenic differentiation potential of MSCs was unaltered regardless of the NPs types, and the P-NPs did not have obvious impact on the osteogenic differentiation potential of MSCs either. The osteogenic differentiation potential of the MSCs was significantly impaired on incubation with the C-NPs, as evid

关键词： Mesenchymal Stem Cells metal oxide nanoparticles surface modification surface chemistry cellular uptake