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Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota

Journal of Environmental Sciences 2023年第5期127卷 603-614页

作者： Chenyang Ji Yunkai Luo Jiawen Yang Yaoyao Dai Jiahui Miao Siqing Yue Meirong Zhao Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province Interdisciplinary Research AcademyZhejiang Shuren UniversityHangzhou 310015China Department of Ultrasound in Medicine The Fourth Affiliated Hospital of Zhejiang University School of MedicalYiwu 322000China Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province College of EnvironmentZhejiang University of TechnologyHangzhou 310014China

Polyhalogenated carbazoles(PHCZs)have been widely accepted as emerging pollutants,whereas their ecological and health risks remain ***,female and male Sprague-Dawley(SD)mice were treated with four typical PHCZs to investigate their negative consequences,along with alternations in gutmicrobiota to indicate *** female mice,the relative liver weight ratio increased after four PHCZs exposure;2-bromocarbazole(2-BCZ)increased urine glucose level;3-bromocarbazole(3-BCZ)decreased the glucose and total cholesterol levels;3,6-dichlorocarbazole(3,6-DCCZ)decreased glucose *** only disturbed biochemical index in male mice was the promoted alkaline phosphatase(ALP)level by 3,*** also found that the differential blood biochemical indices were correlated with gut microbiota.3-BCZ and 3,6-DCCZ altered Bacteroidetes and Proteobacteria phyla in female and male mice,which were correlated with metabolic *** findings demonstrated the correlation between PHCZs induced potential hepatotoxicity andmetabolic disordersmay be due to their dioxin-like potentials and endocrine disrupting activities,and the gender differences might result from their estrogenic ***,data presented here can help to evaluate the ecological and health risks of PHCZs and reveal the underlying mechanisms.

关键词： Polyhalogenated carbazoles Liver metabolic disorders Gut microbiota

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The influence of metabolic disorders on adaptive immunity

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Cellular & Molecular Immunology 2024年第10期21卷 1109-1119页

作者： Thomas J.C.Collins Pooranee K.Morgan Kevin Man Graeme I.Lancaster Andrew J.Murphy Division of Immunometabolism Baker Heart and Diabetes InstituteMelbourneVIC3004Australia Department of Immunology Monash UniversityMelbourneVIC3004Australia Peter Doherty Institute for Infection and Immunity MelbourneVIC3000Australia Department of Microbiology and Immunology University of MelbourneParkvilleVIC3052Australia

The immune system plays a crucial role in protecting the body from invading pathogens and maintaining tissue *** homoeostatic lipid metabolism is an important aspect of efficient immune cell function and when disrupted immune cell function is *** are numerous metabolic diseases whereby systemic lipid metabolism and cellular function is *** the context of metabolic disorders,chronic inflammation is suggested to be a major contributor to disease progression.A major contributor to tissue dysfunction in metabolic disease is ectopic lipid deposition,which is generally caused by diet and genetic ***,we propose the idea,that similar to tissue and organ damage in metabolic disorders,excessive accumulation of lipid in immune cells promotes a dysfunctional immune system(beyond the classical foam cell)and contributes to disease ***,we review the evidence that lipid accumulation through diet can modulate the production and function of immune cells by altering cellular lipid *** can impact immune cell signalling,activation,migration,and death,ultimately affecting key aspects of the immune system such as neutralising pathogens,antigen presentation,effector cell activation and resolving inflammation.

关键词： Immunity metabolic disorders Lipid Metabolism Cell Metabolism Immunometabolism Cancer

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metabolic disorders of fatty acids and fatty acid amides associated with human gastric cancer morbidity

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Chinese Medical Journal 2012年第5期125卷 757-763页

作者： SONG Hu PENG Jun-sheng YAO Dong-sheng LIU Da-ling YANG Zu-li DU Yan-ping XIANG Jun Department of Gastrointestinal Surgery Xuzhou Central Hospital（Affiliated Hospital of Medical College of Southeast University）Xuzhou Jiangsu 221009 China Department of Gastrointestinal Surge% Sixth Affiliated Hospital（Gaslrointestinal ＆ Anal Hospital） Sun Yat-sen University GuangzhouGuangdong 510655 China National Engineering Research Center of Genetic Medicine Ji NanUniversity Guangzhou Guangdong 510632 China

Background Gastric cancer （GC） is one of the most common types of cancer in the world. A change in the metabolism of lipids in tumor cells could lead to the pathogenesis of cancer. In this study, we investigated fat... 详细信息

关键词： gastric cancer fatty acids amides metabolic disorders

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Impact of the adherence to medical treatment on the main urinary metabolic disorders in patients with kidney stones

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Asian Journal of Urology 2021年第3期8卷 275-279页

作者： Braulio Omar Manzo Jose David Cabrera Esteban Emiliani Hector Manuel Sanchez Brian Howard Eisner Jose Ernesto Torres Urology Department Hospital Regional de Alta Especialidad del BajioBlvd.Milenio#130Col.San Carlos la RonchaLeonGuanajuatoMexico Urology Department Fundacion PuigvertUniversidad Autonoma de BarcelonaBarcelonaSpain Urology Department Massachusetts General HospitalHarvard Medical SchoolBostonUSA

Objective:To assess the effect of the adherence to medical treatment on urinary parameters in the 24-h metabolic study of patients with kidney ***:A retrospective,longitudinal,descriptive,and observational study was carried out by reviewing the hospital electronic medical record from 2014 to *** adherence to drug treatment was measured 6 months after its initiation,and the numerical values of the metabolic studies were *** tests were performed to compare the difference before and after ***:Ninety patients were evaluated,with 73.3% of *** 180-day overall adherence rate was 61.2% in patients treated with a single drug and 85.4% in patients treated with multiple *** is a statistically significant increase in citrate levels in patients with good adherence in comparison with non-adherent patients(p=0.031 vs.p=0.528).Conclusions:Medical treatment and dietary measures in patients with kidney stones have an initial impact at 6 months on the values of the main urinary metabolic alterations that predispose to calculi formation;the most significant is seen in those patients with adherence to medical treatment for hypocitraturia.

关键词： Kidney stones Renal stones metabolic disorders Medical treatment Citrate Oxalate Lithiasis

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The journey of gut microbiome - An introduction and its influence on metabolic disorders

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Frontiers in Biology 2018年第5期13卷 327-341页

作者： Ankita Chattopadhyay Mythili S. School of Bio Sciences and Technology VIT University Vellore - 632014 Tamil Nadu India

BACKGROUND： metabolic disorders such as Obesity, Diabetes Type 2 （T2DM） and Inflammatory Bowel Diseases （IBD） are the most prevalent globally. Recently, there has been a surge in the evidence indicating the correlation between the intestinal microbiota and development of these metabolic conditions apart from predisposing genetic and epigenetic factors. Gut microbiome is pivotal in controlling the host metabolism and physiology. But imbalances in the microbiota patterns lead to these disorders via several pathways. Animal and human studies so far have concentrated mostly on metagenomics for the whole microbiome characterization to understand how microbiome supports health in general. However, the accurate mechanisms connecting the metabolic disorders and alterations in gut microbial composition in host and the metabolites employed by the microorganisms in regulating the metabolic disorders is still vague. OBJECTIVE： The review delineates the latest findings about the role of gut microbiome to the pathophysiology of Obesity, IBD and Diabetes Mellitus. Here, we provide a brief introduction to the gut microbiome followed by the current therapeutic interventions in restoration of the disrupted intestinal microbiota. METHODS： A methodical PubMed search was performed using keywords like ＂gut microbiome,＂＂obesity, diabetes,＂＂IBD,＂ and ＂metabolic syndromes.＂ All significant and latest publications up to January 2018 were accounted for the review. RESULTS： Out of the 93 articles cited, 63 articles focused on the gut microbiota association to these disorders. The rest 18 literature outlines the therapeutic approaches in maintaining the gut homeostasis using probiotics, prebiotics and faecal microbial transplant （FMT）. CONCLUSION： metabolic disorders have intricate etiology and thus a lucid understanding of the complex host-microbiome inter-relationships will open avenues to novel therapeutics for the diagnosis, prevention and treatment of the metabolic diseases.

关键词： gut microbiome metabolic disorders obesity diabetes type 2 inflammatorybowel diseases probiotics prebiotics FMT

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Prevalence of metabolic Syndrome and Its Associations with Other metabolic disorders and Cardiovascular Changes in Health Examination Population in Beijing

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Chinese Medical Sciences Journal 2009年第4期24卷 227-230页

作者： Wei-ming Kang Jie-shi Zhang Min-shan Wang Ying-chao Gu Jian-chun Yu Department of General Surgery Health Examination Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the prevalence of metabolic syndrome(MS) and its associations with other metabolic disorders and cardiovascular changes in health examination population in *** Totally,10 916 individuals who received health examination in Health Examination Center of Peking Union Medical College Hospital were *** height,weight,blood pressure,serum levels of triglyceride,high-density lipoprotein cholesterol(HDL-C),and fasting blood glucose were *** was diagnosed based on the working criteria of Chinese Diabetes Society 2004(CDS2004).Meanwhile,other metabolic disorders,including fatty liver and hyperuricemia,were *** cardiovascular changes were reflected by the reports of electrocardiogram(ECG) ST-T changes and atherosclerosis of retinal *** The overall prevalence rate of MS was 6.1%(666/10 916) in the *** prevalence rate of MS in male was much higher than that in female(9.0% vs.2.7%,P=0.000).For individuals with MS,the prevalence rates of fatty liver and hyperuricemia were significantly higher than those without MS,respectively(70.4% vs.35.4%,P=0.000;29.9% vs.17.7%,P=0.000).As for cardiovascular changes,the prevalence rates of ECG ST-T changes and atherosclerosis of retinal arteries were significantly higher in individuals with MS than those without MS,respectively(13.8% vs.11.7%,P=0.012;12.0% vs.6.8%,P=0.000).Conclusions The prevalence of MS in Beijing population is *** individuals with MS have a higher risk for other metabolic disorders and cardiovascular changes.

关键词： metabolic syndrome prevalence metabolic disorders cardiovascular changes

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Prediction of metabolic disorders Using NMR-Based Metabolomics:The Shanghai Changfeng Study

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Phenomics 2021年第4期1卷 186-198页

作者： Qi Wu Qing-xia Huang Hai-luan Zeng Shuai Ma Huan-dong Lin Ming-feng Xia Hui-ru Tang Xin Gao Department of Endocrinology and Metabolism Zhongshan HospitalFudan Institute for Metabolic DiseaseHuman Phenome InstituteFudan UniversityShanghai 2000032China State Key Laboratory of Genetic Engineering School of Life SciencesMetabonomics and Systems Biology LaboratoryHuman Phenome InstituteFudan UniversityShanghai 201203China

A metabolically healthy status,whether obese or not,is a transient stage with the potential to develop into metabolic disor-ders during the course of *** investigated the incidence of metabolic disorders in 1078 metabolically healthy Chinese adults from the Shanghai Changfeng Study and looked for metabolites that discriminated the participants who would develop metabolic disorders in the *** were divided into metabolically healthy overweight/obesity(MHO)and meta-bolically healthy normal weight(MHNW)groups according to their body mass index(BMI)and metabolic *** serum metabolomic profile was measured using a ^(1)H nuclear magnetic resonance spectrometer(^(1)H-NMR).The prevalence of diabetes,hypertriglyceridemia,hypercholesterolemia and metabolic syndrome was similar between the MHNW and MHO participants at *** a median of 4.2 years of follow-up,more MHO participants became metabolically unhealthy than MHNW ***,a subgroup of MHO participants who remained metabolically healthy(MHO→MHO)had a similar prevalence of metabolic disorders as the MHNW participants at the follow-up examination,despite a signifi-cant reduction in their serum concentrations of high-density lipoprotein(HDL)and an elevation in valine,leucine,alanine and *** correlation analysis indicated that serum intermediate-density lipoprotein(IDL)and very low-density lipoprotein cholesterol(VLDL-CH)might be involved in the transition from metabolically healthy to unhealthy status and could be valuable to identify the MHNW and MHO with increased metabolic risks.

关键词： metabolically healthy normal weight(MHNW) metabolically healthy overweight/obesity(MHO) ^(1)H nuclear magnetic resonance spectrometer(^(1)H-NMR) metabolic disorders Very low-density lipoprotein cholesterol(VLDL-CH) Intermediate-density lipoprotein(IDL)

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A novel function of CREG in metabolic disorders

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Medical Review 2021年第1期1卷 18-22页

作者： Yang Li Xiaoxiang Tian Quanyu Zhang Chenghui Yan Yaling Han Cardiovascular Research Institute and Department of Cardiology General Hospital of Northern Theater CommandShenyang 110016LiaoningChina

metabolic disorders are public health problems that require prevention and new efficient drugs for *** repressor of E1A-stimulated genes(CREG)is ubiquitously expressed in mature tissues and cells in mammals and plays a critical role in keeping cells or tissues in a mature,homeostatic ***,CREG turns to be an important mediator in the development of metabolic *** in this review,we briefly discuss the structure and molecular regulation of CREG along with the therapeutic strategy to combat the metabolic disorders.

关键词： CREG insulin resistance metabolic disorders NAFLD obesity skeletal muscle energy metabolism.

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Liujunzi decoction ameliorats cisplatin-induced anorexia via adjusting metabolic disorders in rats

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中国药理学与毒理学杂志 2021年第10期35卷 728-729页

作者： DAI Yong-zhao CHEN Si-qi NIE Ke School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China

OBJECTIVE Cisplatin is a formidable chemotherapy agent widely applying in antineoplastic treatments,but its side effects often limit the clinical *** disorders are one of the side effects induced by cisplatin,which closely relate to the onset of chemotherapy-induced anorexia(CIA)in cancer patients but lacks effective *** decoction(LJZD)is a traditional Chinese formula that has a promising effect in treating ***,whether LJZD ameliorates CIA through adjusting cisplatin-induced metabolic disorders remain *** present study evaluated the mechanism of cisplatin-induced metabolic disorders,and the effect of LJZD in ameliorating these *** 42 male Sprague-Dawley(SD)rats(180-220 g)were randomly divided into 3 groups:normal control group(distilled water+saline),model group(distilled water+cisplatin),LJZD group(4.8 g·kg^(-1)Liujunzi decoction ingredients+cisplatin).Intragastrical administered each drug twice a day(7∶00-19∶00)since day 0 for 4 d,animals were intraperitoneal injected with cisplatin 6 mg·kg^(-1)1 h after administration while normal control groups were injected with same volume of *** day 3,each group was anesthetized with pentobarbital sodium 45 mg·kg^(-1)(ip),and blood samples were collected from aorta *** the samples were analyzed using an LC-ESI-MS/MS *** regulated metabolites between groups were determined by VIP≥1 and absolute Log2FC(fold change)≥*** metabolites were mapped to Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway database using Metaboanalyst 5.0(https://***/).RESULTS A total of 133,77 and 32 differential metabolites were filtrated in control vs model,control vs LJZD and model vs LJZD groups *** to control,the levels of hexadecanoic acid(Log2FC=6.3153),linoleic acid(Log2FC=5.3478),and 8,11-icosadienoic acid(Log2FC=5.2342)significantly increased,and the levels of N-acetyl-L-tyrosine(Log2FC=-2.6283),cinnamic a

关键词： Liujunzi decoction chemotherapy-induced anorexia cisplatin metabolomic metabolic disorders

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Prevalence of stroke and metabolic disorders in the middle-aged and elderly Chinese with type 2 diabetes

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Chinese Medical Journal 2014年第20期127卷 3537-3542页

作者： Zhang Xuebing Mu Yiming Yan Wenhua Ba Jianming Li Hongmei Department of Endocrinology Chinese People's Liberation ArmyGeneral Hospital Beijing 100853 China Department of Endocrinology Meitan General Hospital Beijing100028 China

Background Stroke is now the most prevalent and debilitating disease affecting diabetic population in China. The study aimed to investigate the prevalence of stroke and metabolic disorders in the middle-aged and elderly Chinese with type 2 diabetes. Methods A total of 4 629 subjects with type 2 diabetes （males： 1 917; females： 2 712） aged ≥ 40 years from Shijingshan district, Beijing, China from November 2011 to August 2012 were included in the study. Data on demographic information, lifestyle, history of diabetes mellitus, stroke, coronary heart disease, hypertension, and dyslipidemia were collected. The oral glucose tolerance test or a standard meal test was performed. Non-fatal stroke was reported by the subjects. The 2-tailed test was used, and P 〈0.05 was regarded as statistically significant. Results Prevalence of stroke in the subjects with type 2 diabetes was 5.5%. The prevalence of smoking, overweight or obesity, hypertension, and dyslipidemia was 41.0%, 65.8%, 67.4%, and 52.0% in males, and 2.2%, 65.5%, 69.5%, and 57.6% in females. Multivariate Logistic regression analysis showed that increased age, hypertension, diabetic duration, and overweight or obesity were positively correlated with stroke in the population with type 2 diabetes, whereas high- density lipoprotein cholesterol level was negatively correlated with stroke. After adjustment for age and gender, the odds ratio values of stroke in subjects having 1,2 or ≥3 of 4 risk factors, including smoking, overweight or obesity, hypertension and dyslipidemia, were 2.302 （95% CI： 0.789-6.712）, 4.089 （95% CI： 1.470-11.373）, 6.023 （95% CI： 2.176-16.666）, compared with subjects without any of the above 4 risk factors. Conclusions The prevalence of stroke was higher in middle-aged and eldedy Chinese with type 2 diabetes than that in the general population. With the aggregation of risk factors, the prevalence of stroke increased.

关键词： middle-aged and elderly stroke type 2 diabetes metabolic disorders

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