Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota

作     者：Chenyang Ji Yunkai Luo Jiawen Yang Yaoyao Dai Jiahui Miao Siqing Yue Meirong Zhao Chenyang Ji;Yunkai Luo;Jiawen Yang;Yaoyao Dai;Jiahui Miao;Siqing Yue;Meirong Zhao

作者机构：Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang ProvinceInterdisciplinary Research AcademyZhejiang Shuren UniversityHangzhou 310015China Department of Ultrasound in MedicineThe Fourth Affiliated Hospital of Zhejiang University School of MedicalYiwu 322000China Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang ProvinceCollege of EnvironmentZhejiang University of TechnologyHangzhou 310014China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2023年第127卷第5期

页      面：603-614页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

基　　金：supported by Joint Innovation Fund for Regional Development of National Natural Science Foundation of China(No.U20A20134) Leading Talent of Technological Innovation of Ten-Thousands Talents Program of Zhejiang Province(No.2020R52012) 

主　　题：Polyhalogenated carbazoles Liver Metabolic disorders Gut microbiota 

摘      要：Polyhalogenated carbazoles(PHCZs)have been widely accepted as emerging pollutants,whereas their ecological and health risks remain ***,female and male Sprague-Dawley(SD)mice were treated with four typical PHCZs to investigate their negative consequences,along with alternations in gutmicrobiota to indicate *** female mice,the relative liver weight ratio increased after four PHCZs exposure;2-bromocarbazole(2-BCZ)increased urine glucose level;3-bromocarbazole(3-BCZ)decreased the glucose and total cholesterol levels;3,6-dichlorocarbazole(3,6-DCCZ)decreased glucose *** only disturbed biochemical index in male mice was the promoted alkaline phosphatase(ALP)level by 3,*** also found that the differential blood biochemical indices were correlated with gut microbiota.3-BCZ and 3,6-DCCZ altered Bacteroidetes and Proteobacteria phyla in female and male mice,which were correlated with metabolic *** findings demonstrated the correlation between PHCZs induced potential hepatotoxicity andmetabolic disordersmay be due to their dioxin-like potentials and endocrine disrupting activities,and the gender differences might result from their estrogenic ***,data presented here can help to evaluate the ecological and health risks of PHCZs and reveal the underlying mechanisms.