检索结果-南通市图书馆

Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease

引用

Translational Neurodegeneration 2023年第1期12卷 170-188页

作者： Hyunkyung Mo Juryun Kim Jennifer Yejean Kim Jang Woon Kim Heeju Han Si Hwa Choi Yeri Alice Rim Ji Hyeon Ju Present Address:CiSTEM Laboratory Catholic iPSC Research CenterCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine and Health Science College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea YiPSCELL IncOmnibus ParkBanpo-daero 222Seocho-guSeoul 06591Republic of Korea Department of Biology Georgetown University3700 O St NWWashingtonDC 20057USA Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalInstitute of Medical ScienceCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Background Alzheimer’s disease(AD)is the most common neurodegenerative disorder in the elderly,resulting in gradual destruction of cognitive *** on the development of various AD treatments is underway;however,no definitive treatment has been developed ***,we present induced pluripotent stem cell(iPSC)-derived cortical neural stem cell secretome(CNSC-SE)as a new treatment candidate for AD and explore its *** We first assessed the effects of CNSC-SE treatment on neural maturation and electromagnetic signal during cortical nerve cell *** to confirm the efficacy in vivo,CNSC-SE was administered to the 5×FAD mouse model through the nasal cavity(5μg/g,once a week,4 weeks).The cell-mediated effects on nerve recovery,amyloid beta(Aβ)plaque aggregation,microglial and astrocyte detection in the brain,and neuroinflammatory responses were *** analysis of iPSC-derived CNSC-SE revealed that it contained components that could exert neuro-protective effects or amplify cognitive restorative *** Human iPSC-derived CNSC-SE increased neuronal proliferation and dendritic structure formation in ***,CNSC-SE-treated iPSC-derived cortical neurons acquired electrical network activity and action potential *** 5×FAD mice treated with CNSC-SE showed memory restoration and reduced Aβplaque *** Our findings suggest that the iPSC-derived CNSC-SE may serve as a potential,non-invasive therapeutic option for AD in reducing amyloid infiltration and restoring memory.

关键词： Induced pluripotent stem cells Alzheimer’s disease Cortical neural stem cells Secretome Intranasal administration memory disorders Neuroprotective agents

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical observation on effect of scalp electroacupuncture for mild cognitive impairment

引用

Journal of Traditional Chinese Medicine 2013年第1期33卷 46-50页

作者： Hong Zhang Ling Zhao Sha Yang Zhigang Chen Yingkun Li Xiaohong Peng Yulong Yang Manjia Zhu Department of Acupuncture and Tuina the Chengdu University of Tranditional Chinese Medicine Department of Acupuncture the Teaching Hospital of Chengdu University of Tranditional Chinese Medicine Department of Tranditional Chinese Medicine the Chengdu Hospital of Integrated Chinese and Western Medicine Department of Tranditional Chinese Medicine the Sichuan Provincial People's Hospital

OBJECTIVE: To evaluate the therapeutic effect of scalp electroacupuncture for mild cognitive impairment (MCI) in the early stage. METHODS: Two hundred and thirty three MCI patients were randomly divided into three groups: the drug group, the scalp electroacupuncture group, and the syndrome differentiation group. For the scalp electroacupuncture group, the points of Baihui (DU 20), Sishecong (EX-HN1), Fengchi (GB 20), and Shenting (DU 24) were selected. For the syndrome differentiation group, specific acupoints were added on the basis of syndrome differentiation and according to the scale for the differentiation of syndromes in vascular dementia (SDSVD) beside the acupoints used in the scalp electroacupuncture group. For the drug group, nimodipine was orally administered. Each patient was treated for two courses, eight weeks. The score differences in minimental state examination (MMSE), picture recognition, and clock drawing test were observed before and after the treatment. RESULTS: After treatment, the score differences in MMSE and clock drawing test were of obvious statistical significance among three groups (P0.05). There were statistical significant differences in therapeutic effects between the scalp electroacupuncture group and the drug group, and between the syndrome differentiation group and the drug group (P0.05). CONCLUSION: All the three therapies may improve the cognitive function of MCI patients. The therapeutic effects in the scalp electroacupuncture and syndrome differentiation groups were basically the same, but superior to nimodipine.

关键词： memory disorders Electroacupunc-ture Nimodipine Picture recognition Clock draw-ing test

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Batroxobin on Spatial Learning and memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70

引用

Journal of Traditional Chinese Medicine 2000年第4期20卷 297-301页

作者：吴卫平匡培根姜树军张小澍杨炯炯隋南 Albert Chen 匡培梓 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General HospitalPostgraduate Military Medical SchoolBeijing 100853 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General HospitalPostgraduate Military Medical School Beijing 100853 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General Hospital Postgraduate Military Medical SchoolBeijing 100853 PLA 261 Hospital Beijing 100094 Institute of Psychology Chinese Academy of SciencesBeijing 100101

　　The effect of Batroxobin on spatial memory disorder of left temporal ischemic rats and the expression of HSP32 and HSP70 were investigated with Morri`s water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats in searching a goal were significantly longer than those of the sham-operated rats and at the same time HSP32 and HSP70 expression of left temporal ischemic region in rats was significantly increased as compared with the sham-operated rats. However, the mean reaction time and distance of the Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of HSP32 and HSP70 immune reactive cells of Batroxobin-treated rats was also less than that of the ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats; and the down-regulation of the expression of HSP32 and HSP70 is probably related to the attenuation of ischemic injury.

关键词： Oxygenases Animals Batroxobin Brain Ischemia Down-Regulation HSP70 Heat-Shock Proteins Heat-Shock Proteins Heme Oxygenase (Decyclizing) Learning disorders Male Maze Learning memory disorders Random Allocation Rats Rats, Wistar Snake Venoms Spatial Behavior Temporal Lobe

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Batroxobin on Expression of C-Jun in Left Temporal Ischemic Rats with Spatial Learning and memory Disorder

引用

Journal of Traditional Chinese Medicine 2000年第2期20卷 147-151页

作者：吴卫平匡培根姜树军扬炯炯隋南匡培梓张小澍 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General HospitalPostgraduate Military Medical SchoolBeijing 100853 Institute of Psychology Chinese Academy of SciencesBeijing 100101 PLA 261 Hospital Beijing 100094

The effect of Batroxobin on expression of c-Jun in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats, and at the same time c-Jun expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of c-Jun immune reactive cells of Batroxobin-treated rats was also less than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder in temporal ischemic rats, and the down-regulation of the expression of c-Jun is probably related to the neuroprotective mechanism.

关键词： Genes, jun Animals Batroxobin Gene Expression Hypoxia-Ischemia, Brain Male memory disorders Proto-Oncogene Proteins c-jun Random Allocation Rats Rats, Wistar Temporal Lobe

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Batroxobin on Expression of Neural Cell Adhesion Molecule in Temporal Infarction Rats and Spatial Learning and memory Disorder

引用

Journal of Traditional Chinese Medicine 2001年第4期21卷 294-298页

作者：吴卫平管兴志匡培根姜树军扬炯炯隋南 AlbertChen 匡培梓张小澍 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General HospitalPostgraduate Military Medical SchoolBeijing 100853 Institute of Psychology Chinese Academy of SciencesBeijing 100101 PLA 261 Hospital Beijing 100094China

The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of NCAM immune reactive cells of Batroxobin-treated rats was more than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of the expression of NCAM is probably related to the neuroprotective mechanism.

关键词： Animals Batroxobin Cell Adhesion Molecules, Neuronal Cerebral Infarction Male Maze Learning memory disorders Neuroprotective Agents Random Allocation Rats Rats, Wistar Temporal Lobe

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats

引用

Acta Pharmacologica Sinica 2003年第12期24卷 96-102页

作者： HUANG Yu-Wen, CHEN Zhong~2, HU Wei-Wei, ZHANG Li-San, WU Wei, YING Li-Yang, WEI Er-Qing Department of Neurobiology and Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China Department of Neurobiology and Pharmacology School of Medicine Zhejiang University

AIM: To investigate whether or not histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) as evaluated by 8-arm radial maze of rats. METHODS: 8-Arm (4-arm baited) radial maze was used to measure spatial memory in rats. RESULTS: Bilaterally intrahippocampal (ih) injection of MK-801 (0.3 μg/site) impaired working memory and reference memory in rats. Both histamine (50, 100 ng/site, ih) and intraperitoneal (ip) injection of histidine (100, 200 mg/kg) markedly improved the spatial memory deficits induced by MK-801. On the other hand, the ameliorating effect of histidine (100 mg/kg, ip) was completely antagonized by α-fluoromethylhistidine (α-FMH, 5 μg/site, ih), a potent and selective histidine decarboxylase (HDC) inhibitor, and H1-antagonist pyrilamine (1 μg/site, ih), but not by H2-antagonist cimetidine, even at a high dose (2.5 μg/site, ih). CONCLUSION: The hippocampal histamine plays an important role in the ameliorating effect on MK-801-induced spatial memory deficits,

关键词： histamine maze learning dizocilpine memory disorders

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Can outbred mice be used as a mouse model of mild cognitive impairment?

引用

Neural Regeneration Research 2010年第21期5卷 1650-1656页

作者： Fang Wang Wenhua Xu Chao Wang Dewu Huang Guihai Chen Department of Neurology the First Affiliated Hospital of Anhui Medical University Hefei 230022 Anhui Province China Department of Neurology the People's Hospital of Huaibei City Huaibei 235000 Anhui Province China Laboratory of Animal Center Anhui Medical University Hefei 230032 Anhui Province China

Deficits in spatial learning and memory are some of the earliest symptoms in mild cognitive impairment （MCI）. However, there are few valid MCI animal models available to evaluate putative therapeutic strategies. The aim of this study was to obtain a natural animal model of MCI. Outbred Kunming （aged 5 and 12.5 months） and ICR （7 and 12 months） mice were utilized in the present study. Morris water maze and radial six-arm water maze （RAWM） were simultaneously used to evaluate impaired spatial learning and memory in middle-aged mice （approximately 12 months of age）. Compared with younger mice in the respective groups, the middle-aged mice suffered visible impairment of spatial memory in the Morris water maze and RAWM, and mild spatial learning deficiency occurred in the RAWM study alone. Thus outbred Kunming and ICR mice could be utilized as a natural animal model for MCI, in particular for memory impairment studies.

关键词： middle-aged mice animal models memory disorders Alzheimer's disease neurodegenerative diseases neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relationship between event-related potential P300 and first episode schizophrenia

引用

Chinese Medical Journal 2007年第4期120卷 339-341页

作者： CHEN Xing-shi LU Ying-zhi WANG Ji-jun WANG Hong-xing ZHANG Ming-dao LOU Fei-yin CHEN Chong Department Of Electrophysiology Shanghai Mental Health Center Shanghai 200030China Depantment of Psychiatry Fifth People＇s Hospital Zibo 255120Shandong Province China Department of Electronic EphalographySource Imaging Shanghai Mental Health Center Shanghai 200030China

Although P300 abnormalities of event-related .potentials （ERPs） are consistently reported among schizophrenic patients as being the most compelling indices of their brain dysfunction, whether they are trait markers or state markers of schizophrenia remains in controversy. To shed a light on this point, we made a longitudinal study of P300 among first episode schizophrenic patients, from no medication until the patients had been medicated for 12 weeks.

关键词： schizophrenia event-relatedpotentials, P300 memory disorders

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

THE RESEARCH ON MECHANISMS OF AMYLOID- β PROTEIN INDUCING ALZHEIMER'S DISEASE IN RAT AND EFFECTS OF NIMODIPINE TREATMENT

引用

中国临床神经科学 2000年第Z1期8卷 81-页

作者： Chunfeng Liu Shiyao Bao Yongping Dai Department of Neurology 2nd Affiliated Hospital Suzhou Medical College Department of Neurology 2nd Affiliated Hospital Suzhou Medical College Department of Neurology 2nd Affiliated Hospital Suzhou Medical College

0bjective In order to clarify the mechanism of the neurotoxics of Aβ, we studied the effects on the rCBF, extra-cellular amino acid (EAA), apoptosis and Bcl-2 protein expression, and their relationship with learning and memory deficiency. Methods Aβ was injected into NBM in rats to establish the AD model, learning and memory abilities were observed by Y-maze. The rCBF was measured by hydrogen clearance method. The EAA was detected by microdialysis in vivo with HPLC. The apoptosis and Bc1-2 protein expression was examined by flow cytometry. The male SD rats were divided into three groups: the model group was injected Aβ (10 μ g) into NBM of the rat. The control group was injected NaC1 (0.9%) in the same way. The treatment group was made with intraperitoneal injections of Nimodipine for 2 weeks after A β injections. Results The administration of Aβ into rat′s NBM could lead to the loss of learning and memory abilities. It was found that in frontal cortex and hippocampus, the rCBF decrease, however, with no trend of progressive decline. On the other hand, the levels of EAA increased, especially glutamate. Furthermore, A β significantly induced neurons apoptosis of frontal cortex and hippocampi cell, and upregulated the expression of the bcl-2. The Nimodipine might entirely improve rCBF of AD rats nearly to normal level, lessen the release of EAA and augment restrain neurotransmission. It might reduce the apoptosis partly, but it couldn't improve the learning and memory disorders completely. Conclusion The results implied that the neurotoxic effect of Aβ exists multi-mechanism.

关键词： learning and memory protein expression memory disorders flow cytometry In order

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：