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Nature-skin-derived multi-responsive e-skin as on-demand drug-delivery system facilitated melanoma postoperative therapy

引用

Journal of Materials Science & Technology 2024年第21期188卷 155-168页

作者： Manhui Zheng Xuechuan Wang Jiamin Zhang Ouyang Yue Jingyu Zhang Zhongxue Bai Huie Jiang Jiang Wu Ling Wen Xinhua Liu College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXi’an 710021China Institute of Biomass&Functional Materials Shaanxi University of Science&TechnologyXi’an 710021China Department of General Surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China School of Pharmaceutical Sciences Key Laboratory of Biotechnology and Pharmaceutical EngineeringWenzhou Medical UniversityWenzhou 325035China Department of Radiology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China

An ideal strategy for integrated melanoma treatment involves the pursuit of multifunctional biomaterials that possess adjuvant therapy functions,enabling full-scale postoperative relapse prevention,wound healing,and real-time postoperative *** simulation of electronic skin(e-skin),which emulates the mechanical properties and functions of natural skin,holds significant potential for broad biomedical ***,a novel multi-responsive controlled-release e-skin(PADM-MX-Ag-Si@Dox)was developed using natural porcine dermal matrix,MXene nanosheets,silver nanowires(AgNWs),and mesoporous hollow silica microspheres(TSOHSiO_(2)@Dox)for *** resulting e-skin exhibited temperature-,pH-,and electric-responsiveness due to the incorporation of TSOHSiO_(2)@Dox microspheres,which allowed for on-demand controlled-release of *** biomimetic structure of porcine acellular dermal matrix(PADM)can significantly accelerate the wound healing process under the synergistic effect of electrical stimulation(ES).PADM-MX-Ag-Si@Dox has demonstrated remarkable antimicrobial and electrophysiological activities,thereby establishing a robust basis for enhancing wound healing and facilitating real-time postoperative tumor *** in vitro and in vivo investigations have substantiated that the combined utilization of PADM-MX-Ag-Si@Dox and ES results in a proactive amalgamation of melanoma postoperative relapse prevention,wound healing,and real-time postoperative surveillance,thereby establishing a potent therapeutic approach for postoperative cancer adjuvant therapy and paving the way for novel precision medical care.

关键词： Acellular dermal matrix Multi-responsive properties Drug-delivery system melanoma postoperative therapy,wound healing

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