Nature-skin-derived multi-responsive e-skin as on-demand drug-delivery system facilitated melanoma postoperative therapy

作     者：Manhui Zheng Xuechuan Wang Jiamin Zhang Ouyang Yue Jingyu Zhang Zhongxue Bai Huie Jiang Jiang Wu Ling Wen Xinhua Liu Manhui Zheng;Xuechuan Wang;Jiamin Zhang;Ouyang Yue;Jingyu Zhang;Zhongxue Bai;Huie Jiang;Jiang Wu;Ling Wen;Xinhua Liu

作者机构：College of Bioresources Chemical and Materials EngineeringShaanxi University of Science&TechnologyXi’an 710021China Institute of Biomass&Functional MaterialsShaanxi University of Science&TechnologyXi’an 710021China Department of General SurgeryThe Second Affiliated Hospital of Soochow UniversitySuzhou 215004China School of Pharmaceutical SciencesKey Laboratory of Biotechnology and Pharmaceutical EngineeringWenzhou Medical UniversityWenzhou 325035China Department of RadiologyDushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2024年第188卷第21期

页      面：155-168页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：financial support from the National Natural Science Foundation of China(Nos.22278257 and 21804084) the Key Research and the Development Program of Shaanxi Province(No.2022GY-272) the Scientific Research Plan Projects of the Shaanxi Education Department(No.22JY013) the Young Talent Support Program Project of Shaanxi University of Science and Technology Association(No.20200424) 

主　　题：Acellular dermal matrix Multi-responsive properties Drug-delivery system Melanoma postoperative therapy,Wound healing 

摘      要：An ideal strategy for integrated melanoma treatment involves the pursuit of multifunctional biomaterials that possess adjuvant therapy functions,enabling full-scale postoperative relapse prevention,wound healing,and real-time postoperative *** simulation of electronic skin(e-skin),which emulates the mechanical properties and functions of natural skin,holds significant potential for broad biomedical ***,a novel multi-responsive controlled-release e-skin(PADM-MX-Ag-Si@Dox)was developed using natural porcine dermal matrix,MXene nanosheets,silver nanowires(AgNWs),and mesoporous hollow silica microspheres(TSOHSiO_(2)@Dox)for *** resulting e-skin exhibited temperature-,pH-,and electric-responsiveness due to the incorporation of TSOHSiO_(2)@Dox microspheres,which allowed for on-demand controlled-release of *** biomimetic structure of porcine acellular dermal matrix(PADM)can significantly accelerate the wound healing process under the synergistic effect of electrical stimulation(ES).PADM-MX-Ag-Si@Dox has demonstrated remarkable antimicrobial and electrophysiological activities,thereby establishing a robust basis for enhancing wound healing and facilitating real-time postoperative tumor *** in vitro and in vivo investigations have substantiated that the combined utilization of PADM-MX-Ag-Si@Dox and ES results in a proactive amalgamation of melanoma postoperative relapse prevention,wound healing,and real-time postoperative surveillance,thereby establishing a potent therapeutic approach for postoperative cancer adjuvant therapy and paving the way for novel precision medical care.