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Efficacy and safety of activating blood circulation and removing blood stasis of Traditional Chinese medicine for managing renal fibrosis in patients with chronic kidney disease:a systematic review and Meta-analysis

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Journal of Traditional Chinese medicine 2023年第3期43卷 429-440页

作者： LUO Xin XIE Jing HUANG Li GAN Wenfan CHEN Ming Hospital of Chengdu University of Traditional Chinese medicine Chengdu 610072China Chengdu University of Traditional Chinese medicine Chengdu 610075China

OBJECTIVE:To evaluate the efficacy and safety of activating blood circulation and removing blood stasis in terms of Traditional Chinese medicine(TCM) for managing renal fibrosis(RF) in patients with chronic kidney disease(CKD).METHODS:We searched randomized controlled trials(RCTs) from eight databases.RESULTS:Sixteen eligible studies with 1,356 participants were included in this study.Compared to treatment with Western medicine(WM) alone,the combined treatment with activating blood circulation and removing blood stasis in terms of TCM(ARTCM) and WM to manage RF in patients with CKD significantly ameliorated type Ⅳ collagen(C-Ⅳ)(SMD:-2.17,95% CI:3.01 to-1.34),type Ⅲ procollagen(PC-Ⅲ)(SMD:-1.08,95% CI:-1.64 to-0.53),laminin(LN)(SMD:-1.28,95% CI:-1.65 to-0.90),transforming growth factor β 1(TGF-β1)(SMD:-0.65,95% CI:-1.18 to-0.12),serum creatinine(Scr)(SMD:-1.36,95% CI:-1.85 to-0.87),blood urea nitrogen(BUN)(MD:-1.51,95% CI:-2.59 to-0.43),and 24 h urine protein(24h Upro)(SMD:-1.23;95% CI:-1.96 to-0.50).The level of hyaluronic acid(HA) was similar in both types of treatment(SMD:-0.74,95% CI:-1.91 to 0.44).The subgroup analysis showed that the duration of 8 weeks might affect the concentration of C-Ⅳ,PC-Ⅲ,and LN(P < 0.05).The effectiveness of the longer duration to C-Ⅳ,PC-Ⅲ,and LN was not certain.However,the result should be interpreted in care.The safety of the treatment using ARTCM and WM could not be evaluated because a few studies had reported adverse effects.The results of the Meta-analysis were not stable enough.There was publication bias for the reports on Scr(P = 0.001),C-Ⅳ(P = 0.001),PC-Ⅲ(P = 0.026),and LN(P = 0.030) and no publication bias for the reports on BUN(P = 0.293).The quality of evidence varied from low to very low.CONCLUSIONS:The combined treatment using ARTCM and WM to manage RF in patients with CKD has some advantages over treatment with WM alone.High-quality RCTs need to be conducted for the strong support.

关键词： medicine Chinese traditional activating blood circulation and removing blood stasis renal fibrosis efficacy safety Meta-analysis systematic review

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Effects of Traditional Chinese medicine on the survival of patients with stage Ⅰ gastric cancer and high-risk factors:a real-world retrospective study

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Journal of Traditional Chinese medicine 2023年第3期43卷 568-573页

作者： HOU Chao ZHANG Yusen YANG Die LI Yifei ZHANG Xiaochun LIU Yanqing Department of Oncology and Hematology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033China College of medicine Yangzhou UniversityYangzhou 225001China the Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese medicine Yangzhou 225001China Oncology Department Yangzhou Hospital of Traditional Chinese MedicineYangzhou 225009China

OBJECTIVE:To investigate the benefits of Traditional Chinese medicine(TCM) therapy for improving the survival of patients with stage I gastric cancer(GC) and high-risk factors in a real-world setting.METHODS:The clinical data of patients who were diagnosed with stage I GC from March 1,2012 to October 31,2020 were collected.Prognostic analysis was performed to explore the high-risk factors that affected the survival of the patients.A Cox multivariate regression model was used to compare the hazard ratios for the mortality risk of patients,especially those with high-risk factors.Kaplan-Meier survival curve and log-rank test were utilized to assess the survival time.RESULTS:Prognostic analysis demonstrated that female sex,tumor invasion into blood vessels,and Ib stage were independent risk factors.The 1-,3-,and 5-year survival rates of the TCM group vs those of the non-TCM group were 100.0% vs 91.0%,97.6% vs 64.5%,and 81.4% vs 55.5%,respectively.A significant difference in median overall survival(m OS) was found between the two groups(χ2 = 7.670,P = 0.006).Subgroup analysis showed that the m OS of female patients and stage Ib patients in the TCM group were longer than those in the non-TCM group (P ≤ 0.001 and 0.001,respectively).CONCLUSIONS:TCM treatment can improve the survival of patients with stage I GC and high-risk factors.

关键词： stomach neoplasms overall mortality integrative medicine medicine Chinese traditional real-world

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Effect of Traditional Chinese medicine combined with Western medicine on blood lipid levels and inflammatory factors in patients with angina pectoris in coronary heart disease identified as intermingled phlegm and blood stasis syndrome:a network Meta-anal

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中医杂志:英文版 2023年第4期43卷 640-649页

作者： WANG Chao WU Qiong LI Ping WANG Zhigang LOU Xusheng LI Yuanyuan ZHANG Lin Postdoctoral Mobile Station of Chinese Academy of Traditional Chinese medicine Beijing 100700China China Academy of Chinese Medical Sciences Beijing 100700China Zang-xiang Teaching and Research Department the Institute of Basic Theory for Chinese MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Department of Cardiovascular medicine Beijing University of Chinese medicine Third Affiliated Hospital Beijing 100029China Shandong College of Traditional Chinese medicine Yantai 264199China School of Traditional Chinese medicine Beijing University of Chinese MedicineBeijing 102488China

OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network Meta-analysis.METHODS:Randomized controlled trials(RCTs)on clinical efficacy of CHD angina pectoris with interaction of phlegm and blood stasis were searched in PubMed,Springer,the Cochrane Library and Chinese-language databases China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data from their inception to December 2021.Literature was screened and literature bias risk was assessed by RevMan5.4 software.The overall response rate,the duration of angina attack,the levels of serum lipids such as total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C),and expression of hypersensitive C-reactive protein(hs-CRP)were selected as outcome indicators for network Meta-analysis and mapped using Stata15.1 software.RESULTS:Totally,26 RCTs were included,involving 2098 participants.There were 6 TCM formulas with the effects of dispelling phlegm and removing blood stasis.Taking conventional Western medicine as the common intervention measures,the results showed that the overall response improvement rate from high to low was displayed as modified Xiaoxianxiong decoction(小陷胸汤,MXD),Danlou tablet(丹蒌片,DT),modified Gualou Xiebai Banxia decoction(瓜蒌薤白半夏汤,MGXBD),modified Wendan decoction(温胆汤,MWD),modified Zhishi Xiebai Guizhi decoction(枳实薤白桂枝汤,MZXGD),and modified Erchen decoction(二陈汤,MED).The sequence of angina attack duration improvement from high to low was MZXGD,MGXBD,DT,MWD,MXD.The sequence of TC improvement from high to low was MZXGD,MED,DT,and MGXBD.Sequence of improving TG from high to low was MED,MZXGD,MGXBD,and DT.For LDL-C improvement,the effect from good to poor was MZXGD,MGXBD,DT,and MED.With regard to HDL-C improvement,the effect was ranked as MED,MZXGD,MGXBD,and DT from good to poor.hs-CRP expression from high

关键词： coronary disease angina pectoris phlegm and blood stasis interaction blood lipid inflammatory factors medicine traditional Chinese network Meta-analysis randomized controlled trial

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Effectiveness of Traditional Chinese medicine on coronavirus disease 2019 in 92 patients:a retrospective study

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Journal of Traditional Chinese medicine 2023年第3期43卷 582-587页

作者： XU Guihua CHEN Feifei ZHANG Wei WU Yingen CHEN Xiaorong SHI Kehua WANG Zhenwei SHI Miaoyan ZHANG Xing LU Yunfei YUAN Weian LYU Hua CHEN Xuan Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China Shanghai Hospital of Traditional Chinese medicine Shanghai 200071China Yueyang Hospital of Integrated Traditional Chinese and Western medicine Shanghai 200437China

OBJECTIVE:To investigate the antipyretic effect of early treatment with Traditional Chinese medicine(TCM) on coronavirus disease 2019(COVID-19) patients.METHODS:We retrospectively analyzed 369 patients from January 26th,2020 to April 15th,2020,who had been diagnosed with COVID-19.Among 92 eligible cases,45 cases were identified as treatment group Ⅰ(n = 45) and 47 cases were identified as treatment group Ⅱ.Patients in the treatment group Ⅰ were treated with TCM herbal decoction within 5 d after admission.Patients in the treatment group Ⅱ were treated with TCM herbal decoction after the 6th admission day.The onset time of antipyretic effect,the antipyretic time,the time of negative oropharyngeal swab nucleic acid conversion,and the changes of cell count in blood routine test were compared.RESULTS:The treatment group Ⅰ showed shorter average antipyretic duration(4 vs 7 d;P 38 ℃,patients in the treatment group I had shorter median onset time of antipyretic effect than those in the treatment group Ⅱ(3 vs 4 d;P < 0.05).The absolute lymphocyte(LYMPH) count and absolute eosinophil(EOS) count on the 3rd day after admission and the neutrophil/lymphocyte ratio on the 6th day after admission of patients in the treatment group I were notably different from those in the treatment group Ⅱ at the same time point(P < 0.05).Based on Spearman’s rank correlation analysis,the change of body temperature on the 3rd day after admission was positively correlated with the increase of EOS count and the increase of EOS count and LYMPH counts on the 6th day after admission(P < 0.01).CONCLUSIONS:Early TCM intervention within 5 d after hospital admission shortened the onset time of antipyretic effect and fever duration of COVID-19 patients,reduced the time required for PCR test results to turn negative.Moreover,early TCM intervention also impr

关键词： COVID-19 medicine Chinese traditional antipyretics immune-inflammatory parameters retrospective studies

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Special Issue: The Global Cross-cultural Integration of TCM in the Mainstream Healthcare, Medical Education and the Practice of medicine

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Chinese medicine and Culture 2024年第1期7卷 F0002-F0002页

Ioannis Solos Ph.D.,M.D.(China),L.Ac.currently serves as President and CEO at the Saint George Clinic and Research Institute,Scottsdale,AZ.,and Associate Editor for Chinese medicine and Culture.Professor Solos has earned his Master of medicine in Traditional Diagnosis at the Beijing University of Chinese medicine,and his Medical Ph.D.in Chinese and Western Integrative medicine at the Jinan University in Guangzhou.He practices and teaches integrative clinical medicine,Jing Fang(经方TCM formulas),martial lineage acupuncture,and his personalized style of“tendon and fascia reconditioning manipulations for bone and joint disease”.

关键词： medicine Medical acupuncture

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Toxic medicine used in Traditional Chinese medicine for cancer treatment: are ion channels involved?

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Journal of Traditional Chinese medicine 2022年第6期42卷 1019-1022页

作者： LIU Hengrui Biocomma Limited Shenzhen 518000China

Cancer has been one of the most serious public health issues in the world. Traditional medicines are widely used in adjunctive therapies in clinical cancer treatment in many countries. One of the unique traditional medicine usages in tumor treatment is the high-dose application of traditional toxin medicine, including venom or body from toxin animals. Evidence has shown that they are very likely to have direct effects on cancer cells. One of the potential pharmacological effects of traditional toxin medicines is their regulation of ion channels in cancers. Many ion channels are found critical in cancers. This study suggested that ion channels were involved in the effect of traditional toxin medicine on cancers. However, so far, the study of the effect of traditional toxin medicine on ion channels in cancers is relatively lacking. This perspective article urged the study in this field because, given the fact that these traditional toxin traditional medicines have been widely used in cancer treatment, the identification of the effective components and pharmacological targets can improve their clinical application.

关键词： neoplasms ion channels venoms toxin medicine traditional

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Chinese medicine Rescues Acute Respiratory Dyspnea Syndrome Caused by COVID-19:A Case Report

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Chinese Journal of Integrative medicine 2022年第1期28卷 76-80页

作者： LIU Shi-xu XIA Kun BIAN Yong-jun LI Guang-xi Department of Respiratory Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China Graduate School of Beijing University of Chinese medicine Beijing(100053)China

The novel coronavirus disease 2019(COVID-19)pandemic has struck a devastating blow to our global health.With its over 100 million reported cases and 2 million death tolls across over 200 countries,every country is see... 详细信息

关键词： medicine Acute death

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An example of toxic medicine used in Traditional Chinese medicine for cancer treatment

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Journal of Traditional Chinese medicine 2023年第2期43卷 209-210页

作者： LIU Hengrui Tianjin Yinuo Biomedical Co. Ltd.Tianjin 061102China

An interesting paper “Toxicmedicine used in Traditional Chinese medicine for cancer treatment:are ion channels involved?”1 was published in the Journal of Traditional Chinese medicine on August 17 this year.This paper proposed a unique view of the potential role of ion channels in the pharmacological effects of toxic Traditional Chinese medicine(TCM) for cancer.

关键词： treatment Traditional medicine

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Pharmacokinetics of traditional Chinese syndrome and recipe:a hypothesis and its verification(Ⅰ)

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World Journal of Gastroenterology 2000年第3期6卷 384-391页

作者： Xi Huang Ping Ren Ai Dong Wen Li Li Wang Li Zhang Feng Gao Laboratory of Clinical Pharmacology of Chinese medicine,Xijing Hospital,The Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Department of Pharmacy,Xijing Hospital,The Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Department of Physiology,The Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China 第四军医大学陕西西安

AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS The pharmacokinetics（PK）of samedose of drug was studied in the animal model oftraditional Chinese syndrome（S）and healthyanimals.The classification,terminology,concept and significance of the hypothesis wereset forth with evidence provided in the presentstudy.The hypotheses consisted of traditionalChinese syndrome PK（S-PK）and traditionalChinese recipe PK（R-PK）.Firstly,the observedtetramethylpyrazine（TMP）PK in healthy,chronically reserpinized rats（rat model ofspleen deficiency syndrome,RMSDS）andRMSDS treated with Sijunzi decoction（SJZD）forconfirmation were used to verify S-PK; secondly,the ferulic acid（FA）PK in healthy andhigh molecular weight dextran（HMWD）-inducedrabbit model with blood stasis syndrome（RDBSS）was also used to verify S-PK;andlastly,TMP PK parameters in serum of healthyrats after orally taken Ligusticum wallichii（LW）,LW and Salvia miltiorrhiza（LW&SM）decoctions were compared to verify R-PK.RESULTS The apparent first-order absorption[Ka,（13.61±2.56）h-1,area under the blooddrug concentration-time curve[AUC,（24.88±9.76）μg.h-1mL-1],maximum drug concentration[Cmax,（4.82±1.23）μg·mL-1]of serum TMP inRMSDS were increased markedly（P-1,AUC=（5.20±2.57）μg·h-1·mL-1,Cmax=（2.33±1.77）μg·mL-1]of healthy rats（HR）.Theapparent first-order rate constant for α and βdistribution phase[α=（0.38±0.09）h-1,β=（0.06±0.03）h-1,the apparent first-orderintercompartmental transfer rate constants[K10=（0.24±0.07）h-1,K12=（0.11±0.02）h-1,K21=（0.11±0.02）h-1]of serum TMP in RMSDS weredecreased significantly（P10=（0.88±0.20）h-1,K12=（1.45

关键词： traditional Chinese syndrome/recipe Chinese medicine pharmacokinetics blood stasis spleen deficiency hypothesis

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Auscultation transformed:the ingenious invention of the stethoscope by René Théophile Hyacinthe Laennec

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History & Philosophy of medicine 2024年第2期6卷 23-27页

作者： René Figueroa Joseph Varon Universidad Autónoma de Baja California Facultad de Ciencias de la Salud Tijuana 22260Mexico Dorrington Medical Associates Houston 77030USA The University of Houston College of medicine Houston 77204USA

This study delves into the life and significant contributions of René Théophile Hyacinthe Laennec,a prominent French physician of the 19^(th) century,and thoroughly examines his revolutionary creation,the stethoscope.Laennec’s innovative spirit not only revolutionized medical diagnosis during his time but also left a lasting imprint on the broader field of medicine,influencing healthcare for generations.This extensive inquiry covers various aspects,including his historical context,the development of the stethoscope,its profound implications for medical diagnosis,and its enduring impact on the history of medicine.

关键词： Laennec stethoscope diagnostic auscultation cardiovascular pulmonary innovation medicine

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