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Effect of Yang-activating and stasis-eliminating decoction from traditional chinese medicine on intestinal mucosal permeability in rats with ulcerative colitis induced by dextran sulfate sodium

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Journal of traditional chinese medicine 2017年第4期37卷 452-460页

作者： Shi Lijie Shi Lei Liu Leilei Feng Xiuxian Wang Jing Yang Qiang Chai Shiwei Gou Jing Zang Fenglin He Sufei Department of Spleen and Stomach First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Graduate School of Beijing University of chinese medicine Beijing 100029 China Department of Graduate School of Tianjin University of traditional chinese medicine Tianjin 300000 China Department of Spleen and Stomach Shijiazhuang Traditional Chinese Medicine hospital Shijiazhuang 050000 China Department of Pharmacy First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Clinical Laboratory First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Pathology Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China Department of Scientific Research Tianjin University of Traditional Chinese Medicine Tianjin 300073 China

OBJECTIVE: To evaluate the effect of decoction prepared with Yang-activating and stasis-eliminating medicinals from traditional chinese medicine(TCM) on the intestinal mucosal permeability in rats with ulcerative colitis induced by dextran sulfate sodium(DSS).METHODS: Totally 55 male Wistar rats(body weight of 170-190 g) were randomly divided into the blank group(n = 10) and the model duplication group(n = 45). The blank group was not intervened, while the other was modeled with 5% dextran sulfate sodium by gavaging in a dosage of4 m L per day to induce ulcerative colitis, a total of7 days. Then, the model rats were divided into model blank group, mesalazine group and TCM group,and each group was consisted of 15 rats. They were given retention enema 10 min with normal saline,mesalazine enema(0.036 g/m L), and Yang-activating and stasis-eliminating decoction [0.54 g/m L of a decoction boiled by Puhuang(Pollen Typhae), Xiebai(Bulbus Allii Macrostemonis) and Wulingzhi(Faeces Trogopteri)] for 10 days respectively. Afterwards,all of the rats were evaluated by disease activity index(DAI), histological changes of distal colon, expression of occludin protein and ultrastructure of intestinal epithelial cells. Furthermore, ratio of lactulose to mannitol(L/M) discharged in urine was ***: Comparing the results between TCM and model control groups, scores of DAI and histological lesions decreased significantly(P = 0.000 0.05).CONCLUSION: The decoction prepared with Yang-activating and stasis-eliminating TCM medicianls can restore intestinal mucosal epithelial cells and tight junctions the model rats with ulcerative colitis; it can redu

关键词： Colitis, ulcerative Epithelial cells Intestinal mucosa Permeability Occludin Dextran sulfate Removing blood stasis Activating Yang medicine, chinese traditional

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Effectiveness of co-treatment with traditional chinese medicine and letrozole for polycystic ovary syndrome:a meta-analysis

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Journal of Integrative medicine 2017年第2期15卷 95-101页

作者： Qian-wen Ma Yong Tan The First Clinical Medical College Nanjing University of Chinese Medicine Department of Gynecology Zhenjiang Hospital of Traditional Chinese Medicine

BACKGROUND： Polycystic ovary syndrome （PCOS） is an endocrine disease that affects gynecologica health. Treatment of PCOS remains a big challenge for clinicians. OBJECTIVE： This meta-analysis was developed to compare the efficacy of co-treatment with traditiona chinese medicine （TCM） and letrozole against letrozole monotherapy in the treatment of PCOS. SEARCH STRATEGY： Randomized controlled trials （RCTs） were electronically retrieved from PubMed, Cochrane Library, China Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang Data; related papers that were not available electronically were manually checked. All papers were assessed according to the Cochrane Handbook for Systematic Reviews of Interventions and the valid data were analyzed using Revman software （The Cochrane Collaboration, Copenhagen, Denmark） INCLUSION CRITERIA： We included RCTs that compared co-treatment with TCM and letrozole against letrozole monotherapy in women with PCOS, which was defined by anovulation, biochemical or clinical hyperandrogenemia and polycystic ovaries. We included trials from all sources. DATA EXTRACTION AND ANALYSIS： Two independent reviewers extracted data, and evaluated study quality according to the Cochrane Handbook for Systematic Reviews of Interventions criteria for RCT, including issues of patient randomization, blinding and bias. RESULTS： Eight RCTs, involving a total of 537 patients, were included in the present study. The meta-analysis showed that the cycle ovulation rate, the pregnancy rate and the total effective rate of symptom treatment were higher in treatments combining TCM with letrozole, compared with letrozole monotherapy. Although the rate of luteinizing hormone （LH）/follicle-stimulating hormone （FSH） and the body mass index of the group receiving combined therapy were lower than in letrozole monotherapy, no statistical difference was found in the LH and FSH level between the two groups. CONCLUSION： Available evidence showed that c

关键词： medicine, chinese traditional letrozole polycystic ovary syndrome meta-analysis

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Identification and classification of traditional chinese medicine syndrome types among senior patients with vascular mild cognitive impairment using latent tree analysis

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Journal of Integrative medicine 2017年第3期15卷 186-200页

作者： Chen Fu Nevin Lianwen Zhang Bao-xin Chen Zhou Rong Chen Xiang Lan Jin Rong-juan Guo Zhi-gang Chen Yun-ling Zhang Department of Neurology Dongfang HospitalBeijing University of Chinese Medicine Department of Computer Science and Engineering The Hong Kong University of Science and Technology

OBJECTIVE： To treat patients with vascular mild cognitive impairment （VMCI） using traditional chinese medicine （TCM）, it is necessary to classify the patients into TCM syndrome types and to apply different treatments to different types. In this paper, we investigate how to properly carry out the classification for patients with VMCI aged 50 or above using a novel data-driven method known as latent tree analysis （LTA）. METHOD： A cross-sectional survey on VMCI was carried out in several regions in Northern China between February 2008 and February 2012 which resulted in a data set that involves 803 patients and 93 symptoms. LTA was performed on the data to reveal symptom co-occurrence patterns, and the patients were partitioned into clusters in multiple ways based on the patterns. The patient clusters were matched up with syndrome types, and population statistics of the clusters are used to quantify the syndrome types and to establish classification rules. RESULTS： Eight syndrome types are identified： Qi deficiency, Qi stagnation, Blood deficiency, Blood stasis, Phlegm-dampness, Fire-heat, Yang deficiency, and Yin deficiency. The prevalence and symptom occurrence characteristics of each syndrome type are determined. Quantitative classification rules are established for determining whether a patient belongs to each of the syndrome types. CONCLUSION： A solution for the TCM syndrome classification problem for patients with VMCI and aged 50 or above is established based on the LTA of unlabeled symptom survey data. The results can be used as a reference in clinic practice to improve the quality of syndrome differentiation and to reduce diagnosis variances across physicians. They can also be used for patient selection in research projects aimed at finding biomarkers for the syndrome types and in randomized control trials aimed at determining the efficacy of TCM treatments of VMCI.

关键词： vascular mild cognitive impairment medicine, chinese traditional syndrome latent tree analysis

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A data-driven method for syndrome type identification and classification in traditional chinese medicine

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Journal of Integrative medicine 2017年第2期15卷 110-123页

作者： Nevin Lianwen Zhang Chen Fu Teng Fei Liu Bao-xin Chen Kin Man Poon Pei Xian Chen Yun-ling Zhang Department of Computer Science and Engineering the Hong Kong University of Science and Technology Department of Neurology Dongfang HospitalBeijing University of Chinese Medicine Department of Mathematics and Information Technology the Education University of Hong Kong

The efficacy of traditional chinese medicine （TCM） treatments for Western medicine （WM） diseases relies heavily on the proper classification of patients into TCM syndrome types. The authors developed a data-driven method for solving the classification problem, where syndrome types were identified and quantified based on statistical patterns detected in unlabeled symptom survey data. The new method is a generalization of latent class analysis （LCA）, which has been widely applied in WM research to solve a similar problem, i.e., to identify subtypes of a patient population in the absence of a gold standard. A well-known weakness of LCA is that it makes an unrealistically strong independence assumption. The authors relaxed the assumption by first detecting symptom co-occurrence patterns from survey data and used those statistical patterns instead of the symptoms as features for LCA. This new method consists of six steps： data collection, symptom co-occurrence pattern discovery, statistical pattern interpretation, syndrome identification, syndrome type identification and syndrome type classification. A software package called Lantern has been developed to support the application of the method. The method was illustrated using a data set on vascular mild cognitive impairment.

关键词： medicine, chinese traditional syndrome syndrome classification latent tree analysis symptomco-occurrence patterns patient clustering stand syndrome differentiation

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A history of standardization in the English translation of traditional chinese medicine terminology

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Journal of Integrative medicine 2017年第5期15卷 344-350页

作者： Xiao Ye Hong-xia Zhang College of Humanities and Social Sciences Zhejiang Chinese Medical University Confucius Institute University of Coimbra Faculty of Education East China Normal University

In order to facilitate and propose further international standardization of traditional chinese medicine（TCM） terminology, this article applies methods of historiography, philology and descriptive study to divide the history of TCM into three phases, based on representative experts and social events; to illustrate different aspects of these experts and their translation principles and standards and to discuss associated factors and inherent problems. The authors find that the development of a terminology standard for TCM has generally progressed from early approaches that were ill-suited to the contemporary needs to culturally and professionally referenced approaches, from uncoordinated research to systematic studies, and from individual works to collaborative endeavors. The present international standards of TCM terminology have been attained through the work of numerous scholars and experts in the history of the field. The authors are optimistic that a more comprehensive and recognized standard will come out soon.

关键词： standardization terminology English translation history medicine, chinese traditional

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Prospects of a comprehensive evaluation system for traditional chinese medicine services

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Journal of Integrative medicine 2017年第6期15卷 426-432页

作者： Wen-jie Xu Ling-tai Wang Zhi-ping Zhao Li-ming Zhu Liang-hua Zu Qi Zhang Dan-bo Dou Center for International Classification Research on traditional medicine Clinical Conditions and Service Evaluation Shanghai University of Traditional Chinese Medicine Department of traditional chinese medicine Shuguang Hospital Shanghai University of Traditional Chinese Medicine Division of traditional chinese medicine Service Supervision Shanghai Municipal Commission of Health and Family Planning traditional and Complementary medicine World Health Organization

traditional chinese medicine （TCM） is a unique health resource in China and one of the main representative traditional medicines globally. TCM has formed a new way of looking at medical practices, health care, scientific research, education, industry and culture. It focuses on promoting and safeguarding the health of people, with an increasing contribution to economic and social development. Establishing a comprehensive evaluation system in accordance with the characteristics of TCM services could promote the scientific merit and the standardization of services management. This would improve health service quality and the social and economic benefits of TCM. It would broaden the field of TCM services research. It would also provide the basis for the formulation of relevant government policies. This study estimates the prospect of establishing a comprehensive evaluation system of TCM services.

关键词： medicine, chinese traditional complementary medicine alternative medicine evaluationsystem review

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Progress in research on the effects of traditional chinese medicine on the tumor microenvironment

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Journal of Integrative medicine 2017年第4期15卷 282-287页

作者： Wan-fu Lin Jian-ying Lu Bin-bin Cheng Chang-quan Ling Changhai Hospital of traditional chinese medicine Second Military Medical University Department of traditional chinese medicine Jing'an Hospital of Integrated Traditional Chinese and Western Medicine

Tumor microenvironment （TME） has received more and more attention as modern medical research has begun to understand its importance in tumorigenesis. The occurrence, development, metastasis and drug resistance of tumors are closely related to TME. TME is a complicated system, including nontumor cells, their secreted cytokines, extracellular matrix, among other components. The concepts of wholism and multitarget regulation in traditional chinese medicine （TCM） make it well suited to the regulation of TME. in this paper, the authors reviewed the progress of TME research and the effect of TCM on TME, providing some views of chinese medicine in antitumor research.

关键词： tumor microenvironment medicine, chinese traditional chinese medicine monomer chinesemedicine compound research progress

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Consensus on the integrated traditional chinese and Western medicine criteria of diagnostic classification in polycystic ovary syndrome(draft)

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Journal of Integrative medicine 2017年第2期15卷 102-109页

作者： Jin Yu Chao-qin Yu Qi Cao Li Wang Wen-jun Wang Li-rong Zhou Jing Li Qiao-hong Qian Department of Integration of Western and traditional chinese medicine Obstetrics and Gynecology Hospital of Fudan University Gynaecologic Department of traditional chinese medicine Changhai Hospital of Traditional Chinese MedicineSecond Military Medical University

Polycystic ovary syndrome （PCOS） is the most common endocrine and metabolic disorder of women, with complex pathogenesis and heterogeneous manifestations. Professor Jin Yu recently wrote an article entitled ＂Proposal of Diagnosis and Diagnostic Classification of PCOS in Integrated traditional chinese and Western medicine.＂ From this, the Obstetrics and Gynecology branches of the chinese Association of Integrative medicine and the China Association of chinese medicine collaborated with the Gynecology branch of the chinese Association for Research and Advancement of chinese medicine to draft a report on the consensus of criteria for the diagnosis and classification of PCOS in integrated traditional chinese and Western medicine. The diagnosis for PCOS includes all three features：（1） oligo-ovulation or anovulation; （2） clinical and/or laboratory evidence of hyperandrogenism; （3） PCOS is classified into four types： types la, Ib, Ila, and lib. Syndrome differentiation types for PCOS in traditional chinese medicine are as follows： Kidney deficiency with phlegm blockage syndrome, Kidney Yin deficiency with phlegm blockage and blood stasis syndrome, and Kidney deficiency with Liver Qi stagnation syndrome.

关键词： polycystic ovary syndrome consensus diagnosis classification integrative medicine holistichealth medicine, chinese traditional

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Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of traditional chinese medicine

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Journal of traditional chinese medicine 2014年第2期34卷 214-220页

作者： Zhangbin Yang Ting Xiang Shijun Zhang Hongrui Zhan Zexiong Chen Baoguo Sun Xiaoling Chen Jingli Shi Bin Ren Department of traditional chinese medicine the First Affiliated Hospital of Sun Yat-Sen University Department of traditional chinese medicine the Fifth Affiliated Hospital of Sun Yat-Sen University Department of Physical medicine and Rehabilitation the Fifth Affiliated Hospital of Sun Yat-Sen University Department of Pharmacy the First Affiliated Hospital of SunYat-Sen University

OBJECTIVE： This study investigated how polypeptide 2B1 is involved in regulating and governing dampness in rat models with dampness pattern defined in terms of traditional chinese medicine. METHODS： We randomly divided 48 SPF 10-week-old male Sprague-Dawley （SD） rats into a normal group, normal ＋ Aristolochic acid I （AA-I） for 5 min group, normal ＋ AA-I for 60 min group, dampness pattern group （DS-Group）, dampness pattern ＋ AA-I for 5 rain tern ＋ AA-I for 60 min group, and dampness pat- group. Groups were then treated accordingly. We took out the lung, stom- ach, liver, spleen, kidney, large intestine, and small intestine tissues to detect gene and protein expres- sion of organic anion transporter polypeptide 2B1 （OATP2B1）. RESULTS= Gene expression of OATP2B1 in spleen, kidney, and small intestine of rats with dampness pattern was lower than that in normal rats （P〈0.05）. The gene expressions of OATP2B1 in liver, stomach, large intestine, and small intestine were lower than that in control rats at different time points after being stimulated by AA-I （P〈0.05）. CONCLUSION There is coordination among multiple viscera in handling the condition of dampness, and the mechanism underlying the action may rely on regulating the expression of OATP2B1.

关键词： medicine, chinese traditional Viscera Organic anion transporter polypeptide 2B1 Dampness pattern Aristolochic acid

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traditional chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis

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Journal of Integrative medicine 2017年第6期15卷 469-475页

作者： xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue department of traditional chinese medicine changzheng hospitalsecond military medical universityShanghai 200003China

OBJECTIVE： traditional chinese medicine （TCM） is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer. METHODS： In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status （KPS） score were measured as the main outcome. RESULTS： The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3- and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups （x2 = 42.244, P 〈 0.001 ）. After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively （P 〈 0.001）. The Cox regression analysis showed that TCM treatment is a protective factor for patients＇ overall survival. CONCLUSION： This study demonstrated that TCM integrated with chemotherapy may prolong overal survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer

关键词： stomach neoplasms drug therapy, combination medicine, chinese traditional integrativemedicine plants, medicinal

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