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Network pharmacology and experimental validation of maxing shigan decoction in the treatment of influenza virus-inducedferroptosis

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Chinese Journal of Natural Medicines 2023年第10期21卷 775-788页

作者： HUANG Jiawang MA Xinyue LIAO Zexuan LIU Zhuolin WANG Kangyu FENG Zhiying NING Yi LU Fangguo LI Ling College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China The Medicine School of Hunan University of Chinese Medicine Changsha 410208China Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China

Influenza is an acute viral respiratory infection that has caused high morbidity and mortality *** A virus(IAV)has been found to activate multiple programmed cell death pathways,including *** is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation,leading to cell ***,little is known about how influenza viruses induce ferroptosis in the host *** this study,based on network pharmacology,we predicted the mechanism of action of maxing shigan decoction(MXSGD)in IAV-induced ferroptosis,and found that this process was related to biological processes,cellular components,molecular function and multiple signaling pathways,where the hypoxia inducible factor-1(HIF-1)signaling pathway plays a significant ***,we constructed the mouse lung epithelial(MLE-12)cell model by IAV-infected in vitro cell experiments,and revealed that IAV infection induced cellular ferroptosis that was characterized by mitochondrial damage,increased reactive oxygen species(ROS)release,increased total iron and iron ion contents,decreased expression of ferroptosis marker gene recombinant glutathione peroxidase 4(GPX4),increased expression of acyl-CoA synthetase long chain family member 4(ACSL4),and enhanced activation of hypoxia inducible factor-1α(HIF-1α),induced nitric oxide synthase(iNOS)and vascular endothelial growth factor(VEGF)in the HIF-1 signaling *** with MXSGD effectively reduced intracellular viral load,while reducing ROS,total iron and ferrous ion contents,repairing mitochondrial results and inhibiting the expression of cellular ferroptosis and the HIF-1 signaling ***,based on animal experiments,it was found that MXSGD effectively alleviated pulmonary congestion,edema and inflammation in IAV-infected mice,and inhibited the expression of ferroptosis-related protein and the HIF-1 signaling pathway in lung tissues.

关键词： Network pharmacology Experimental validation maxing shigan decoction Influenza Ferroptosis HIF-1 signaling pathway

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Network pharmacology research of mechanism of maxing shigan decoction in treating COVID-19

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Quantitative Biology 2023年第1期11卷 94-103页

作者： Xian-Fang Wang Zhi-Yong Du Qi-Meng Li Yi-Feng Liu Shao-Hui Ma Jui-Wei Cui School of Computer Science and Technology Henan Institute of TechnologyXinxiang 453003China School of Sanquan Xinxiang Medical UniversityXinxiang 453003China School of Computer and Information Engineering Henan Normal UniversityXinxiang 453003China School of the First Clinical Xinxiang Medical UniversityXinxiang 453003China

Background:The COVID-19 has a huge negative impact on people’s *** Chinese Medicine(TCM)has a good effect on viral *** is of great practical significance to study its ***:The ingredients and targets of each herb in maxing shigan decoction which obtained from Traditional Chinese Medicine Systems Pharmacology(TCMSP)database,and the related targets of COVID-19 were screened by GeneCards database based on the network *** was used to analyze the intersection target between active ingredients and *** software was used to construct an active ingredient-disease target *** protein-protein interaction network was constructed by STRING database and Cytohubba was used to screen out the key *** Ontology(GO)functional enrichment analysis and KEGG pathway analysis were performed by DAVID ***:In this study,a total of 134 active ingredients and 229 related targets,198 targets of COVID-19 and 48 common targets of drug-disease were *** items and pathways were obtained through GO and KEGG pathway *** predicted active ingredients were quercetin,kaempferol,luteolin,naringenin,glycyrol,and the key targets involved IL6,MAPK3,MAPK8,CASP3,IL10,*** results showed that the active ingredients of maxing shigan decoction acted on multiple targets which played roles in the treatment of COVID-19 by regulating inflammation,immune system and other ***:The main contribution of this paper is to use data to mine the principles of the treatment of COVID-19 from the pharmacology of these prescriptions,and the results can be provided theoretical reference for medical workers.

关键词： network pharmacology PPI maxing shigan decoction COVID-19 target

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Different Effects of Mahuang decoction and maxing shigan decoction on Animal Temperature Tropism and Correlation to Differences of Cold and Hot Nature of Chinese Materia Medica

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Chinese Herbal Medicines 2010年第3期2卷 211-215,243页

作者： WANG Jia-bo1, ZHAO Yan-ling1, ZHANG Xue-ru1,2, ZHOU Can-ping1,2, LIU Ta-si2, ZHAO Hai-ping1, REN Yong-shen1, XIAO Xiao-he1 1. China Military Institute of Chinese Meteria Medica, 302 Military Hospital of China, Beijing 100039, China 2. College of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China China Military Institute of Chinese Meteria Medica 302 Military Hospital of ChinaBeijing 100039China China Military Institute of Chinese Meteria Medica 302 Military Hospital of ChinaBeijing 100039China College of Pharmaceutical Sciences Hunan University of Chinese MedicineChangsha 410208China College of Pharmaceutical Sciences Hunan University of Chinese MedicineChangsha 410208China

Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and maxing shigan decoction (MSD) on animal temperature tropism. Methods The equipment with cold/hot pads was used to investigate the variety of the temperature tropism between two groups of mice treated by MHD and MSD, respectively. Meanwhile, the activities of adenosine triphosphatase (ATPase), superoxide dismutase, succinate dehydrogenase, and malondialdehyde were measured. Results After treated by MHD, the macroscopic behavioral index of remaining rate on warm pad (40 ℃ ) of mice decreased significantly (P < 0.05), suggesting the enhancement of cold tropism, meanwhile, the internal indices of ATPase activity and oxygen consuming volume increased significantly (P < 0.05), suggesting the enhancement of energy metabolism. On the other hand, the above-mentioned indices in MSD group changed on the inverse way. Conclusion The relative drug nature of MHD and MSD revealed in this study is consistent with the theoretical prognostication or definition. It indicates that the internal cold and hot nature of CMM could be reflected in ethological way on the changes of animal temperature tropism which might be internally regulated by body energy metabolism.

关键词： cold/hot nature of Chinese materia medica Mahuang decoction maxing shigan decoction temperature tropism

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