Network pharmacology research of mechanism of Maxing Shigan Decoction in treating COVID-19

作     者：Xian-Fang Wang Zhi-Yong Du Qi-Meng Li Yi-Feng Liu Shao-Hui Ma Jui-Wei Cui Xian-Fang Wang;Zhi-Yong Du;Qi-Meng Li;Yi-Feng Liu;Shao-Hui Ma;Jui-Wei Cui

作者机构：School of Computer Science and TechnologyHenan Institute of TechnologyXinxiang 453003China School of SanquanXinxiang Medical UniversityXinxiang 453003China School of Computer and Information EngineeringHenan Normal UniversityXinxiang 453003China School of the First ClinicalXinxiang Medical UniversityXinxiang 453003China 

出 版 物：《Quantitative Biology》 (定量生物学（英文版）)

年 卷 期：2023年第11卷第1期

页      面：94-103页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.62072157 and 61802116) the Natural Science Foundation of Henan province(202300410102) the Doctoral program of Henan Institute of Technology(KQ2002) the Science and Technology Research Key Project of Henan Province(No.192102210113) 

主　　题：network pharmacology PPI Maxing Shigan Decoction COVID-19 target 

摘      要：Background:The COVID-19 has a huge negative impact on people’s *** Chinese Medicine(TCM)has a good effect on viral *** is of great practical significance to study its ***:The ingredients and targets of each herb in Maxing Shigan Decoction which obtained from Traditional Chinese Medicine Systems Pharmacology(TCMSP)database,and the related targets of COVID-19 were screened by GeneCards database based on the network *** was used to analyze the intersection target between active ingredients and *** software was used to construct an active ingredient-disease target *** protein-protein interaction network was constructed by STRING database and Cytohubba was used to screen out the key *** Ontology(GO)functional enrichment analysis and KEGG pathway analysis were performed by DAVID ***:In this study,a total of 134 active ingredients and 229 related targets,198 targets of COVID-19 and 48 common targets of drug-disease were *** items and pathways were obtained through GO and KEGG pathway *** predicted active ingredients were quercetin,kaempferol,luteolin,naringenin,glycyrol,and the key targets involved IL6,MAPK3,MAPK8,CASP3,IL10,*** results showed that the active ingredients of Maxing Shigan Decoction acted on multiple targets which played roles in the treatment of COVID-19 by regulating inflammation,immune system and other ***:The main contribution of this paper is to use data to mine the principles of the treatment of COVID-19 from the pharmacology of these prescriptions,and the results can be provided theoretical reference for medical workers.