检索结果-南通市图书馆

Cellular & Molecular Immunology 2018年第12期15卷 1038-1046页

作者： Xiao-Qiu Wang Wen-Jie Zhou Xin-Xin Hou Qiang Fu Da-Jin Li Laboratory for Reproductive Immunology Key Laboratory of Reproduction Regulation of NPFPCSIPPRShanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesHospital and Institute of Obstetrics and GynecologyIRDFudan UniversityShanghai Medical CollegeShanghaiChina College of Basic Medicine Binzhou Medical UniversityYantaiShandongChina

Decidual macrophages (dMΦ) are distinct from the conventional macrophages present in other tissues and express M2macrophage markers, but the molecular mechanisms of formation and the roles of M2 MΦ during pregnancy have not beencompletely elucidated. The crosstalk between decidual natural killer cells (dNK) and dMΦ plays an important role in themaintenance of maternal–fetal immune tolerance. Here, CXCL16 derived from first-trimester trophoblast cells induces thepolarization of human M2 macrophages. The M2 MΦ polarized by CXCL16 exhibit decreased interleukin-15 production, whichfacilitates the inactivation of NK cells. The cytotoxicity of NK cells is attenuated by the CXCL16-polarized M2 MΦ. The data shown inthe present study provide evidence to support the hypothesis that CXCL16 secreted by trophoblast cells is a key molecule involvedin decidual M2 MΦ polarization, which in turn regulates the killing ability of NK cells, thereby contributing to the homeostatic andimmune-tolerant milieu required for successful fetal development.

关键词： CXCL16 trophoblasts macrophage polarization NK cells maternal-fetal interface

IL-24 Expression at maternal-fetal interface and Its Roles in Trophoblast Invasion

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第4期28卷 456-459页

作者：程红邹丽 Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology

In this study, the expression of IL-24 at maternal-fetal interface and the roles in extravillous trophoblast （the TEV-1 cell line） invasion were examined. Immunohistochemistry was used to detect the expression of IL-24 in villi and decidual tissue. The proliferation of TEV-1 cells under the effect of IL-24 was measured by MTT assay. The invasiveness of TEV-1 cells under the effect of recombinant IL-24 （rhIL-24） was examined by transwell system. Immunohistochemical detection showed that IL-24 was expressed in the villi and decidual tissue, and distributed in villous column, trophoblasts, stroma and blood vessels. The proliferation of TEV-1 cells was not inhibited by rhIL-24 of various concentrations. The examination of invasion in vitro showed that rhIL-24 could inhibit the invasion of TEV-1 cells in a concentration-dependent manner. The results suggested IL-24 could inhibit the invasion of TEV-1 cells. Therefore, IL-24 produced by maternal-fetal interface in human first trimester pregnancy may influence the invasion of trophoblasts and is involved in normal pregnancy.

关键词： IL-24 maternal-fetal interface TEV-1 cell line extravillous trophoblast invasion

The role of extracellular matrix on unfavorable maternal-fetal interface:focusing on the function of collagen in human fertility

在线全文

学校读者我要写书评

暂无评论

Journal of Leather Science and Engineering 2022年第1期4卷 184-200页

作者： Rang Liu Mengyuan Dai Guidong Gong Mei Chen Canhui Cao Tianren Wang Zhenhui Hou Yu Shi Junling Guo Yaoyao Zhang Xi Xia Center for Reproductive Medicine Peking University Shenzhen HospitalFutian DistrictShenzhen 518000GuangdongChina Shantou University Medical College Shantou 515063GuangdongChina BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringChengdu 610065SichuanChina Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education West China Second University HospitalSichuan UniversityChengdu 610041China The University of Hong Kong-Shenzhen Hospital Center for Reproductive MedicineFutian DistrictShenzhen 518000GuangdongChina Department of Ultrasonography Peking University Shenzhen HospitalFutian DistrictShenzhen 518000GuangdongChina State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065SichuanChina The Reproductive Medical Center Department of Obstetrics and GynecologyWest China Second University HospitalSichuan UniversityChengdu 610041China.

Extracellular matrix(ECM)is characterized as widespread,abundant,and *** ECM members,collagen is widely accepted as one of the most prominent components for its essential structural property that can provide a scaffold for other components of ECM and the rich biological functions,which has been extensively used in tissue *** evidence has shown that the balance of ECM degradation and remodeling is vital to regulations of maternal-fetal interface including menstrual cycling,decidualization,embryo implantation and pregnancy ***,disorders in these events may eventually lead to failure of *** the improvement of assisted conception and embryo culture technologies bring hope to many infertile couples,some unfavorable outcomes,such as recurrent implantation failure(RIF),recurrent pregnancy loss(RPL)or recurrent miscarriage(RM),keep troubling the clinicians and ***,in vitro three-dimensional(3D)model mimicking the microenvironment of the maternal-fetal interface is developed to investigate the physiological and pathological conditions of conception and *** progress of this technology is based on clarifying the role of ECM in the endometrium and the interaction between endometrium and *** on collagen,the present review summarized the degradation and regulation of ECM and its role in normal menstruation,endometrium receptivity and unsatisfying events occurring in infertility treatments,as well as the application in therapeutic approaches to improve pregnancy *** investigations about ECM focusing on the maternal-fetal interface interaction with mesenchymal stem cells or local immunoregulation may inspire new thoughts and advancements in the clinical application of infertility treatments.

关键词： Collagen Extracellular matrix(ECM) Matrix metalloproteinases(MMPs) Endometrium maternal-fetal interface Infertility

Mechanisms of Traditional Chinese Medicine Bushenantai granules(补肾安胎颗粒) in promoting angiogenesis at the maternal-fetal interface of recurrent spontaneous abortion mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2021年第4期41卷 556-563页

作者： LI Yuanqi LI Weili YU Xinhui WU Hua WANG Yuanzhong JIN Ya HAO Lele LIU Mingmin SONG Xiaoge Nanjing University of Chinese Medicine Nanjing 230023China Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230000China Anhui University of Chinese Medicine Hefei 230000China

OBJECTIVE:To assess the effects of Bushenantai(BSAT)granule(补肾安胎颗粒)on angiogenesis-related factors[E2,P,and vascular endothelial growth factor(VEGF)]at the maternal-fetal interface of recurrent spontaneous abortion(RSA)mice,and to evaluate the role of BSAT in promoting angiogenesis at the maternal-fetal interface by influencing the expression of sex hormones,and ***:A mouse model with normal pregnancy and another with Clark’s classic RSA were *** RSA mice were randomly assigned to six groups:normal,model,progesterone,high-doseBSAT granule(BSAT-H),medium-dose-BSAT granule(BSAT-M),and low-dose-BSAT granule(BSAT-L)(n=10 for each group).The embryo loss rate and the histopathological changes in the decidual tissues were *** levels of estrogen(E2),progesterone(P),and VEGF were detected by enzyme-linked immunosorbent *** m RNA and protein expressions of estradiol receptor(ER),progesterone receptor(PR),VEGF,and vascular endothelial growth factor receptor 2(VEGFR2)in the decidual tissues were identified by immunohistochemistry,Western blotting,and quantitative reverse transcription polymerase chain ***:The embryo loss rate in all groups that received BSAT treatment was reduced,while the number of blood vessels at decidual tissues was *** serum levels of E2,P and VEGF were elevated,and the m RNA and protein expressions of ER,PR,VEGF,and VEGFR2 in the decidual tissues were ***:BSAT can improve angiogenesis at the maternal-fetal interface and reduce the embryo loss rate,which may be associated with its ability to increase the serum levels of estrogen,progesterone,and VEGF,in addition to up-regulation of m RNA and protein expression of ER,PR,VEGF,and VEGFR2 in the decidual tissues.

关键词： abortion spontaneous progesterone vascular endothelial growth factor angiogenesis maternal-fetal interface Bushenantai granule

同方期刊数据库

Toll-Like Receptor-Dependent Antiviral Responses at the maternal-fetal interface

在线全文

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2020年第4期4卷 249-256页

作者： Liu Xiao-Rui Wei Xiao-Wei Lin Yi Department of Obstetrics and Gynecology Shanghai Key Laboratory of Embryo Original DiseasesSchool of MedicineInternational Peace Maternity and Child Health HospitalShanghai Jiao Tong UniversityShanghai 200030China

The maternal-fetal interface is a key barrier to protect the fetus from ***-like receptors (TLRs) at the maternal-fetal interface are involved in antiviral *** are expressed in both maternal decidua and fetal ***-induced activation of TLR signaling pathways triggers the release of interferon-related antiviral molecules and other inflammatory cytokines and/or chemokines by the host innate immune system,which may disrupt immune tolerance at the maternal-fetal interface and lead to pregnancy *** this review,we summarize the state of knowledge on the most common viral infections during pregnancy,antiviral TLR responses at the maternal-fetal interface,and TLR-associated pregnancy complications.

关键词： Toll-Like Receptor Antiviral Response maternal-fetal interface

Single-cell sequencing analysis of the maternal-fetal interface

在线全文

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2023年第2期7卷 122-127页

作者： Pei-Ru Wei Yi-Hua Yang Center of Reproductive Medicine the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China

The microenvironment at the maternal-fetal interface is optimized to facilitate the development and survival of the fetus during *** involves a balance between cell populations and interactions of the fetal placenta with various cell types(ie,stromal cells,endothelial cells,immune cells,and fibroblasts)that are embedded in the maternal endometrium/*** shifts in cell populations and deranged cell-cell interactions are closely related to pregnancy ***,analysis of the dynamic changes in cell populations and their interactions at the maternal-fetal interface in normal and complicated pregnancies is essential to provide insights into the fundamental processes involved in the establishment and maintenance of normal pregnancy,and how these processes are ***,informing novel pathways for therapeutic targets of pregnancy ***-cell sequencing(SCS)is a powerful tool for transcriptome analysis at single-cell *** with information on the developmental trajectory and function of different cell populations,SCS can provide an unparalleled opportunity for refining the spatiotemporal cell atlas to elaborate dynamic changes in cell populations and their interactions in tissues that consist of highly heterogeneous cell populations such as the maternal-fetal *** minireview briefly summarizes traditional methods and their limitations for analyzing maternal-fetal interface cell-cell interactions,and introduces the current applications,advantages,limitations,and prospective applications of SCS in research on maternal-fetal interactions.

关键词： Single-cell sequencing technology maternal-fetal interface Placenta Decidua

Single-Cell RNA Expression Profiling of ACE2 and AXL in the Human maternal-fetal interface

在线全文

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2020年第1期4卷 7-10页

作者： Qing-Liang Zheng Tao Duan Li-Ping Jin Clinical and Translational Research Center Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China

2019 novel coronavirus disease has resulted in thousands of critically ill patients in China,which is a serious threat to people’s life and *** acute respiratory syndrome-coronavirus 2(SARS-CoV-2)was reported to share the same receptor,angiotensin-converting enzyme 2(ACE2),with ***,based on the public single-cell RNA-sequencing database,we analyzed the mRNA expression profile of putative receptor ACE2 and AXL receptor tyrosine kinase(AXL)in the early maternal-fetal *** result indicates that the ACE2 has very low expression in the different cell types of early maternal-fetal interface,except slightly high in decidual perivascular cells cluster 1(PV1).Interestingly,we found that the Zika virus(ZIKV)receptor AXL expression is concentrated in perivascular cells and stromal cells,indicating that there are relatively more AXL-expressing cells in the early maternal-fetal *** study provides a possible infection route and mechanism for the SARS-CoV-2-or ZIKV-infected mother-to-fetus transmission disease,which could be informative for future therapeutic strategy development.

关键词： 2019 Novel Coronavirus Disease ACE2 AXL maternal-fetal interface Severe Acute Respiratory Syndrome Coronavirus 2 Vertical Transmission

Research Progress of the maternal-fetal interface Immune Microenvironment Regulated by Traditional Chinese Medicine in the Treatment of Recurrent Spontaneous Abortion

在线全文

学校读者我要写书评

暂无评论

Proceedings of Anticancer Research 2021年第6期5卷 20-23页

作者： Jingyi Wang Nan Li Shaanxi University of Chinese Medicine Xianyang 712000Shaanxi ProvinceChina The Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000Shaanxi ProvinceChina

This article is a summary of the research progress of the maternal-fetal interface immune microenvironment regulated by traditional Chinese medicine in the treatment of recurrent spontaneous *** imbalance of the immune microenvironment at the maternal-fetal interface is closely related to the occurrence of recurrent spontaneous *** Chinese medicine can maintain the homeostasis of the immune microenvironment at the maternal-fetal interface by regulating the function of immune cells and the expression of related cytokines.

关键词： maternal-fetal interface Immune microenvironment Traditional Chinese medicine Research progress

TLRs may induce Th1/Th2 responses by affect the secretion of CCL2 at the maternal-fetal interface

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TLRs may induce Th1/Th2 responses by affect the secretion of...

Frontier Progress in the Establishment of Trophoblast Stem Cell and the Identification of New Cell Subtypes at the maternal-fetal interface

第十一届全国免疫学学术大会

作者： Zhang Jin Sun Ya He Yinyan Department of Obstetrics & Gynecology Shanghai General Hospital (Shanghai first people’s hospital)

Background:Toll-like receptors(TLRs)are a family of pattern recognition receptors that recognize specific components of microbes and certain host *** plays an important role in host innate immune *** most of ligands r... 详细信息

关键词： Toll-like receptors CCL2 Th1/Th2 responses maternal-fetal interface

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

maternal-fetal Medicine 2019年第2期1卷 105-112页

作者： Xiao-Bo Zhou Chan Zhou Yang Sun Dong Liu Shuang-Bo Kong Jin-Hua Lu Hong-Bo Qi Hai-Bin Wang Reproductive Medical Center The First Affiliated Hospital of Xiamen UniversityXiamenFujian 361000China Fujian Provincial Key Laboratory of Reproductive Health Research Medical College of Xiamen UniversityXiamenFujian 361000China Department of Obstetrics andGynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Proper development of the human placenta is of vital importance for a successful pregnancy,and a series of pregnancy complications are considered originating from dysfunctional *** other organ system development,placentation requires large numbers of co-regulators,while the underlying molecular mechanisms orchestrating the placental formation and function are poorly *** we have made many signs of progress in understanding the placental architectures and developments using mouse models,the species-specific differences impede our progress due to the lack of appropriate model *** the past few years,major progress has been made by the establishment of novel in-vitro self-renewing stem cell models,as well as identifying the full picture of the cellular organization of the maternal and fetal *** the tools for the investigation of placentation and reproductive-related regulation *** this review,we focus on the detailed progress of the human trophoblast stem cells culturing system,and the cellular and molecular terrain at the maternal-fetal interface,respectively,thus providing new insights into placental development.

关键词： Human placenta maternal-fetal interface Trophoblast stem cell

同方期刊数据库