The role of extracellular matrix on unfavorable maternal-fetal interface:focusing on the function of collagen in human fertility
作者机构：Center for Reproductive MedicinePeking University Shenzhen HospitalFutian DistrictShenzhen 518000GuangdongChina Shantou University Medical CollegeShantou 515063GuangdongChina BMI Center for Biomass Materials and NanointerfacesCollege of Biomass Science and EngineeringChengdu 610065SichuanChina Key Laboratory of Birth Defects and Related of Women and Children of Ministry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041China The University of Hong Kong-Shenzhen HospitalCenter for Reproductive MedicineFutian DistrictShenzhen 518000GuangdongChina Department of UltrasonographyPeking University Shenzhen HospitalFutian DistrictShenzhen 518000GuangdongChina State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065SichuanChina The Reproductive Medical CenterDepartment of Obstetrics and GynecologyWest China Second University HospitalSichuan UniversityChengdu 610041China.
出 版 物：《Journal of Leather Science and Engineering》 (皮革科学与工程（英文）)
年 卷 期：2022年第4卷第1期
页 面：184-200页
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：the Research project of Science&Technology Department of Sichuan Province(Y.Z.,Grant No.2021YJ0416) project of Chengdu Science and Technology Bureau,(Y.Z.,Grant No.2021-YF05-02110-SN) National Natural Science Foundation of China(Y.Z.,Grant No.82001496) China Postdoctoral Science Foundation(Y.Z.,Grant No.2020M680149,2020T130087ZX) China Postdoctoral Science Foundation(C.C.,Grant No.2021M702223) Shenzhen Science and Technology Innovation Committee(C.C.,Grant No.JCYJ20210324105808022) the Research Team of Female Reproductive Health and Fertility Preservation(W.Q.,Grant No.SZSM201612065)
主 题：Collagen Extracellular matrix(ECM) Matrix metalloproteinases(MMPs) Endometrium Maternal-fetal interface Infertility
摘 要：Extracellular matrix(ECM)is characterized as widespread,abundant,and *** ECM members,collagen is widely accepted as one of the most prominent components for its essential structural property that can provide a scaffold for other components of ECM and the rich biological functions,which has been extensively used in tissue *** evidence has shown that the balance of ECM degradation and remodeling is vital to regulations of maternal-fetal interface including menstrual cycling,decidualization,embryo implantation and pregnancy ***,disorders in these events may eventually lead to failure of *** the improvement of assisted conception and embryo culture technologies bring hope to many infertile couples,some unfavorable outcomes,such as recurrent implantation failure(RIF),recurrent pregnancy loss(RPL)or recurrent miscarriage(RM),keep troubling the clinicians and ***,in vitro three-dimensional(3D)model mimicking the microenvironment of the maternal-fetal interface is developed to investigate the physiological and pathological conditions of conception and *** progress of this technology is based on clarifying the role of ECM in the endometrium and the interaction between endometrium and *** on collagen,the present review summarized the degradation and regulation of ECM and its role in normal menstruation,endometrium receptivity and unsatisfying events occurring in infertility treatments,as well as the application in therapeutic approaches to improve pregnancy *** investigations about ECM focusing on the maternal-fetal interface interaction with mesenchymal stem cells or local immunoregulation may inspire new thoughts and advancements in the clinical application of infertility treatments.
维普期刊数据库