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High Ethanol Production by marine-derived Yeasts-<i>Saccharomyces cerevisiae</i>under Stress Pressures

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Advances in Microbiology 2017年第5期7卷 349-357页

作者： Naoto Urano Ayaka Shirao Masahiko Okai Masami Ishida Laboratory of marine Biochemistry Department of Ocean Sciences Tokyo University of Marine Science and Technology Tokyo Japan

For practical applications of bioethanol, the uses of both highly concentrated biomass materials and their effective fermentation by yeasts are indispensable in order to produce ethanol at low costs. However, as the saccharified products of those biomass generally contain abundant sugars, the yeasts are affected by the compounds and are inclined to decrease their physiological activities. In the process of fermentation, ethanol is gradually produced by the yeasts in the culture;the concentrated metabolic product also damages itself, and inhibition of the fermentation frequently occurs. The application of yeasts with high fermentative activities under stress pressures such as sugars and ethanol is thus desired for bioethanol production. In this study, various types of high-fermentative yeasts under stress pressures were isolated mainly from coastal waters in Japan and characterized. All yeast strains with high fermentative activities under 20% v/v ethanol were found to be Saccharomyces cerevisiae. The HK21 strain isolated from Tokyo Bay and identified as S. cerevisiae had the highest fermentation activity under 30% w/v sorbitol and under 20% v/v ethanol, and it produced approx. 70 g/l (9% v/v) ethanol from the 15% w/v glucose solution at 25 oC within 5 days.

关键词： marine-derived Yeast Fermentation Bioethanol Coastal Water Saccharomyces cerevisiae Stress Pressure

Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94

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Acta Pharmaceutica Sinica B 2015年第1期5卷 62-66页

作者： Zhenfang Zhou Xin Wang Hui Zhang Jingya Sun Linghui Zheng Hongchun Liu Jidong Wang Aijun Shen Meiyu Geng Yuewei Guo State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Zhejiang Hisun Pharmaceutical Co. Ltd.

A bicyclic depsipeptide, chromopeptide A(1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K_α radiation(λ ? 0.71073 ?) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC_(50) values of 7.7, 7.0, and 16.5 nmol/L, respectively.

关键词： Chromopeptide A Bacterium Depsipeptide Absolute configuration marine-derived Sediments Cytotoxicity Chromobacterium sp.

Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069

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Chinese Chemical Letters 2019年第1期30卷 44-46页

作者： Chengli Liu Chenglong Yang Yingjie Zeng Jing Shi Lingyu Li Wei Li Ruihua Jiao Renxiang Tan Huiming Ge State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional Biomolecues School of Life Sciences Nanjing University

A novel alkaloid, chartrenoline(1), featuring an unusual 6/6/5/5-tetracyclic nucleus, was isolated from a marine Streptomyces chartreusis NA02069. The structure of 1 including its absolute configurations was established by extensive analyses of its high resolution mass, NMR and single-crystal X-ray diffraction data. A plausible biosynthetic pathway for chartrenoline(1) is proposed.

关键词： Alkaloid Chartrenoline Streptomyces chartreusis 6/6/5/5-Tetracyclic nucleus marine-derived microorganism

Lithocarpinols A and B,a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508

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Chinese Chemical Letters 2019年第2期30卷 439-442页

作者： Jianlin Xu Haibo Tan Yuchan Chen Saini Li Heng Guo Zilei Huang Haohua Li Xiaoxia Gao Hongxin Liu Weimin Zhang State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied Microbiology Guangdong Institute of Microbiology College of Pharmacy Guangdong Pharmaceutical University Program for Natural Products Chemical Biology Key Laboratory of Plant Resources Conservation and Sustainable Utilization Guangdong Provincial Key Laboratory of Applied Botany South China Botanical Garden Chinese Academy of Sciences

Lithocarpinols A(1) and B(2), a pair of tenellone diastereoisomers with novel fused skeleton were isolated from the deep-sea derived fungus Phomopsis lithocarpus FS508. Their structures were elucidated by comprehensive spectroscopic analyses, X-ray diffraction and quantum molecular calculation. Their plausible biogenetic pathway featured an intriguing carbonyl-ene cyclization. Lithocarpinol A exhibited moderate inhibitory effect against HepG-2 and A549 tumor cell lines with IC_(50) values of 9.4 μmol/L and10.9 μmol/L,respectively.

关键词： marine-derived fungus Phomopsis lithocarpus Tenellone derivatives Diastereoisomers Cytotoxicity