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Correlation between slow transit constipation and spleen Qi deficiency, and gut microbiota: a pilot study

Journal of Traditional Chinese Medicine 2022年第3期42卷 353-363页

作者： YU Zeyue HAO Liyu LI Zongyuan SUN Jianhui CHEN Hongying HUO Hairu LI Xiaoqin SHAN Zhongchao LI Hongmei Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100007China Jiangsu University Zhenjiang 212013China Yunnan University of Traditional Chinese Medicine Kunming 650504China Jiangxi University of Traditional Chinese Medicine Nanning 330004China

OBJECTIVE:To investigate the effect of slow transit constipation(STC)and spleen Qi deficiency on gut microbiota,and the mechanism underlying the action that the positive drug maren runchang(MR)alleviates ***:STC was induced,using the cathartic method of Senna and the hunger-fullness disorder method,in ICR mice;one group of model mice was treated with MR(6.24 g/kg).The changes in the general condition,fecal parameters,D-xylose content in the serum,intestinal propulsion rate,and histopathology of the colon were assessed after STC induction in the control,model,and MR *** microbiota transplantation(FMT)was performed from STC mice into pseudo germ-free *** in the contents of substance P(SP),vasoactive intestinal peptide(VIP),and gut microbiota in STC mice and pseudo germ-free mice were assessed after ***:Compared with the control group,the model mice showed the following results:the time of the first black stool was significantly longer(P<0.01),the number and weight of black stools were significantly reduced within 6 h(P<0.05),the D-xylose content in the serum was significantly reduced(P<0.05),the intestinal propulsion rate decreased(P<0.01),the content of VIP in colon tissue significantly increased(P<0.05),and SP content in the colon tissue significantly decreased(P<0.01);moreover,the colon showed significant inflamemation and ***,the abundance of Firmicutes was increased,the abundance of Bacteroides decreased,and the abundance of Alistipes,unclassified_o_Bacteroidales,Alloprevotella,Bilophila,and Anaerotruncus decreased,while the abundance of the conditional pathogenic bacteria Escherichia and Klebsiella ***,after treatment with MR,the time of the first black stool decreased(P<0.01),the number of black stools within 6 h increased,and the intestinal propulsion rate increased(P<0.05).Moreover,the content of D-xylose in the serum and the content of VIP in colon tissue significantly decreased(P<0.05),the conte

关键词： spleen Qi deficiency gastrointestinal microbiome probiotics fecal microbiota transplantation substance P vasoactive intestinal peptide slow transit constipation maren runchang pills

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