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Recent advances in the management of gastrointestinal stromal tumor

World Journal of Clinical Cases 2020年第15期8卷 3142-3155页

作者： Monjur Ahmed Division of Gastroenterology and Hepatology Department of Internal MedicineThomas Jefferson UniversityPhiladelphiaPA 19107United States

gastrointestinal stromal tumor(GIST)is a rare but an important clinical entity seen in our clinical *** is the most common mesenchymal tumor of the gastrointestinal tract and most common malignancy of the small *** the exact prevalence of GIST is not known,the incidence of GIST has been *** arise from interstitial cells of *** of the GISTs occur due to mutation in c-kit gene or platelet derived growth factor receptor alpha gene.15%of GISTs do not have these mutations and they are called wildtype *** all GISTs express KIT receptor tyrosine ***,GISTs look like spindle cell tumors most of the time but they can be epitheloid or mixed *** median size of GISTs varies from 2.7 cm to 8.9 ***,patients with small GISTs remain asymptomatic but as the GIST size increases,patients present with various symptoms depending on the location of the *** of GISTs are located in the stomach or small *** is suspected on imaging and endoscopic studies,and confirmed by tissue acquisition with immunohistochemical *** aggressiveness of GISTs depends on the size,mitotic index and *** resection is the treatment of *** various endoscopic modalities of resection are increasingly being *** kinase inhibitors are extremely useful in the management of large GISTs,unresectable GISTs and metastatic *** options for metastatic GISTs also include radiotherapy,chemotherapy,hepatic artery embolization,chemoembolization and radiofrequency ablation.

关键词： gastrointestinal stromal tumor Mesenchymal tumor of gastrointestinal tract gastrointestinal subepithelial tumors management of gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Risk stratification

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