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Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study

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World Journal of Gastroenterology 2007年第47期13卷 6356-6364页

作者： EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung Department of Diagnostic Radiology University Hospital RegensburgFranz-Josef Strauss-Allee 11Regensburg 93043Germany Department of Radiology Ultrasound SectionGroβhadern HospitalLudwig Maximilian University of MunichMarchioninistr15Mnchen 81377Germany Department of Trauma Surgery Passau HospitalInnstraβe 76Passau 94034Germany Institutes of Radiology Nuclear Medicine and UltrasoundPirmasens HospitalGermany Center for Biomaterial Development Institute of Polymer ResearchGKSSKantstr55Teltow 14513Germany

AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the poss

关键词： Liver tumors malignant tumor Contrast harmonic imaging Quantitative contrast enhancement

Pancreas-preserving duodenectomy for treatment of a duodenal papillary tumor:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4748-4753页

作者： Biao Wu Shi-Yong Chen Yuan Li Yu He Xin-Xin Wang Xiao-Jun Yang Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina

BACKGROUND Duodenal papillary tumor is a rare tumor of the digestive tract,accounting for about 0.2%of gastrointestinal tumors and 7%of periampullary *** clinical manifestations of biliary obstruction are most *** benign tumors or small malignant tumors are often not easily found because they have no obvious symptoms in the early *** resection is the only treatment for duodenal papillary *** present,the methods of operation for duodenal papillary tumors include pancreatoduodenectomy,duodenectomy,ampullectomy,and endoscopic *** SUMMARY A 47-year-old man was admitted to because of a duodenal mass that had been discovered 2 mo *** gastroscopy at another hospital revealed a duodenal papillary mass that had been considered to be a high-grade intraepithelial ***,we conducted a multidisciplinary group discussion and decided to perform a pancreas-preserving duodenectomy and a R0 resection was successfully *** surgery,the patient underwent a follow-up period of 5 *** recurrence or metastasis *** According to our experience with a duodenal papillary tumor,compared with pancreaticoduodenectomy,the use of pancreas-preserving duodenectomy can preserve pancreatic function,maintain gastrointestinal structure and function,reduce tissue damage and complications,and render the postoperative recovery ***-preserving duodenectomy for treatment of a duodenal papillary tumor is feasible under strict control of surgical indications.

关键词： Duodenal papillary tumor Benign tumor malignant tumor Pancreaspreserving duodenectomy Case report

A retrospective study of 2228 cases with eyelid tumors

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1835-1841页

作者： Sha-Sha Yu Yun Zhao Hong Zhao Jin-Yong Lin Xin Tang Clinical College of Ophthalmology Tianjin Medical University Tianjin 300020 China Tianjin Eye Hospital Tianjin 300020 China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin 300020 China Tianjin Eye Institute Tianjin 300020 China

AIM： To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS： In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin： epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location. RESULTS： Most eyelid tumors were epidermal in origin（1080, 48.5%）, followed by miscellaneous（885, 39.7%） and adnexal tumors（263, 11.8%）. Among all the tumors, 292（13.1%） were malignant lesions, 1910（85.7%） benign and 26（1.1%） premalignant lesions. Most malignant tumors originated from epidermal cells（60.0%）, followed by adnexal cells（34.6%）. The most common malignant tumors were basal cell carcinomas（56.5%） followed by sebaceous carcinoma（34.6%）, squamous cell carcinomas（3.8%） and lymphoma/plasmocytoma（1.7%）. The benign and premalignant eyelid lesions mostly originated from epidermal cells（46.4%） followed by miscellaneous cell sources（45.2%）, including melanocytic nevus（33.8%）, seborrheic keratosis（13.7%）, squamous cell papilloma（13.0%） and epidermal cysts（11.5%）. CONCLUSION： Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.

关键词： eyelid tumors benign tumors malignant tumor basal cell carcinoma sebaceous carcinoma squamous cell carcinoma melanocytic nevus

Fever as a first manifestation of advanced gastric adenosquamous carcinoma:A case report

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World Journal of Gastroenterology 2014年第29期20卷 10193-10201页

作者： Harsha Ajoodhea Ren-Chao Zhang Xiao-Wu Xu Wei-Wei Jin Ke Chen Yong-Tao He Yi-Ping Mou Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University Department of Pathology Sir Run Run Shaw HospitalSchool of MedicineZhejiang University

Gastric adenosquamous carcinoma(ASC)is a rare type of gastric *** is a mixed neoplasm,consisting of glandular cells and squamous *** is often diagnosed at an advanced stage,thus carrying a poor *** describe a case of a 73-year-old male,who presented with refractory fever and an intra-abdominal mass on *** underwent a laparoscopic exploration followed by a successful totally laparoscopic total gastrectomy with D2 lymphadenectomy for gastric *** pathology revealed primary gastric ASC(T4aN0M0).The patient received adjuvant radiotherapy and chemotherapy with S1 and is alive 20mo after surgery without *** is the first case of advanced gastric ASC with fever as the initial presentation treated with totally laparoscopic total gastrectomy reported in the English literature.

关键词： Gastric adenosquamous carcinoma Advanced gastric cancer malignant tumor Laparoscopic gastrectomy Totally laparoscopic total gastrectomy

Establishing Chinese Medicine Characteristic tumor Response Evaluation System Is the Key to Promote Internationalization of Chinese Medicine Oncology

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Chinese Journal of Integrative Medicine 2012年第10期18卷 730-736页

作者：李杰黎磊刘瑞林洪生 Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical Sciences Cancer Institute China Academy of Chinese Medical Sciences

The features and advantages of Chinese medicine （CM） in cancer comprehensive treatment have been in the spotlight of experts both at home and abroad. However, how to evaluate the effect of CM more objectively, scientifically and systematically is still the key problem of clinical trial, and also a limitation to the development and internationalization of CM oncology. The change of tumor response evaluation system in conventional medicine is gradually consistent with the features of CM clinical effect, such as they both focus on a combination of soft endpoints （i.e. quality of life, clinical benefit, etc.） and hard endpoints （i.e. tumor remission rate, time to progress, etc.）. Although experts have proposed protocols of CM tumor response evaluation criteria and come to an agreement in general, divergences still exist in the importance, quantification and CM feature of the potential ***, establishing a CM characteristic and wildly accepted tumor response evaluation system is the key to promote internationalization of CM oncology, and also provides a more convenient and scientific platform for CM international cooperation and communication.

关键词： Chinese medicine malignant tumor response evaluation system

HIGH-INTENSITY FOCUSED ULTRASOUND FOR TREATMENT OF UNRESECTABLE tumorS LOCATED IN THE WALLS OF CHEST AND ABDOMEN IN 10 PATIENTS

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Chinese Journal of Cancer Research 2003年第3期15卷 217-222页

作者：郑国强郭峰霍苓李正 Department of Surgical Oncology Peking University School of Oncology Beijing Cancer Hospital Beijing Institute for Cancer Research Beijing 100036

Objective: To present our results of high-intensity focused ultrasound (HIFU) treatment in 10 patients with unresectable tumors involved in the walls of chest and abdomen. Methods: tumors located in the walls of the chest and abdomen in 10 patients were treated by HIFU, including local recurrence of fibrosarcoma in 1 case and local invasion or metastases in 9 cases. All of the 10 patients had received anti-cancer treatments before HIFU, 3 patients were complicated with intercostal neuralgia. Results: Partial responses were obtained in 2 patients, minor response in 1 patient, stable disease in 4, progressive disease in 2 after HIFU treatments. All the intercostal neuralgia in 3 patients was disappeared after HIFU. Bone scan showed that site of rib metastasis before HIFU became normal after HIFU in one patient. Conclusion: Our preliminary results showed that HIFU could get good results for patients with malignant tumors located in the walls of chest and abdomen if they are focal tumors, even if they are complicated with rib metastasis.

关键词： malignant tumor HIFU Chest wall Metastasis Intercostal neuralgia

Biliary stent combined with iodine-125 seed strand implantation in malignant obstructive jaundice

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World Journal of Clinical Cases 2021年第4期9卷 801-811页

作者： Hui-Wen Wang Xiao-Jing Li Shi-Jie Li Jun-Rong Lu Dong-Feng He Department of Interventional Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND malignant obstructive jaundice is mainly caused by *** a few patients are indicated for surgical resection,and the 3-year survival rate is<50%.For patients who are not eligible for surgery,biliary stent pla... 详细信息

BACKGROUND malignant obstructive jaundice is mainly caused by *** a few patients are indicated for surgical resection,and the 3-year survival rate ismalignant obstructive *** We enrolled 67 patients between January 2016 and June 2018 with malignant obstructive jaundice and randomized them into a biliary stent combined with 125I seed strand treatment(combined)group(n=32)and biliary stent(control)group(n=35).All patients underwent enhanced computed tomography and magnetic resonance imaging and were tested for biochemical and cancer *** patients underwent pathological examination before *** patients were followed up by telephone or clinical *** liver function improvement,postoperative complications,stent patency time,and survival time were compared between the two *** risk factors were *** Technical success was achieved in all patients in both *** liver function improved significantly in all patients(total bilirubin,direct bilirubin,alanine aminotransferase,and aspartate aminotransferase decreased significantly in all patients,the P values were less than 0.05).There was no significant difference in preoperative or postoperative indexes between the two groups for changes in total bilirubin(P=0.147),direct bilirubin(P=0.448),alanine aminotransferase(P=0.120),and aspartate aminotransferase(P=0.387)between the two *** median stent patency time of the combined group was 9.0±1.4 mo[95%confidence interval(CI):6

关键词： Biliary stent 125I Obstructive jaundice malignant tumor Clinical research Surgery

Serum Spondin-2 expression,tumor invasion,and antitumor immune response in patients with cervical cancer

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World Journal of Clinical Cases 2022年第36期10卷 13304-13312页

作者： Ling-Li Zhang Song Lin Yan Zhang Dong-Mei Yao Xin Du Department of Gynecology Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina Department of Surgery Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina Department of Women’s Health Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina

BACKGROUND Cervical cancer is a gynecological malignancy common in middle-aged and older patients,with a high mortality ***-2 is an extracellular matrix protein that involved in innate and acquired immune ***,we investigated the relationship between serum Spondin-2 expression,tumor invasion and infiltration,and immune response in patients with cervical cancer and provided a theoretical basis for clinical *** To investigate the relationship between serum Spondin-2 expression and cervical cancer-related *** Overall,147 patients with cervical cancer who were admitted to our institution between January 2019 and August 2019 were assigned to the cervical cancer group,and 92 patients with benign uterine lesions and 86 healthy individuals were assigned to the benign and control groups,*** each group,serum Spondin-2 expression was measured,and the receiver operating characteristic(ROC)curve was *** with cervical cancer were classified into high or low Spondin-2 groups depending on the Spondin-2 threshold value used for diagnosing cervical ***’s clinical data were collected to compare the clinicopathologic characteristics,immune cytokine levels,and prognosis of patients with varying Spondin-2 expression *** The expression level of serum Spondin-2 was significantly higher in the cervical cancer group than in the benign and control groups(Ptumor necrosis factor-αlevels were lower in the high Spondin-2 group than in th

关键词： Cervical cancer Spondin-2 Invasion and infiltration Immune response Prognosis malignant tumor

Modulatory Effects of EPA and DHA on Proliferation and Apoptosis of Pancreatic Cancer Cells

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第5期27卷 547-550页

作者：张维康龙跃平张景辉王春友 Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology

In order to investigate the effects of eicosapentaenoic acid （EPA） and docosahexaenoic acid （DHA） on the proliferation, apoptosis of pancreatic cancer cell line SW1990 cells and the expression of cyclin E mRNA, the SW1990 cells were treated with different concentrations of EPA or DHA （20, 40, 60 μg/mL） for 0, 12, 24, 36 and 48 h respectively. By using MTF method, the inhibitory effects of EPA or DHA on the cell growth were assayed. Real time PCR was used to detect the expression changes of cyclin E mRNA after the SW1990 cells were treated with 40μg/mL EPA or DHA for different time. Flow cytometry was used to test the changes of apoptostic rate in the SW1990 cells treated with different concentrations of EPA or DHA for 24 h. The results showed that EPA and DHA could inhibit the growth of SW1990 cells in a time- and concentration-dependent manner （P〈0.01）. EPA or DHA could also significantly inhibit the expression of cyclin E mRNA in a time-dependent manner （P〈0.05）. EPA or DHA could induce the apoptosis of SW1990 cells in a concentration-dependent manner （P〈0.01）. It was concluded that ω-3 fatty acid could inhibit the proliferation of pancreatic cancer cell line SW1990 cells and promote their apoptosis. The down-regulation of the cyclin E expression by ω-3 fatty acid might be one of the mechanisms for its anti-tumor effect on pancreatic cancer.

关键词： ω-3 fatty acid cyclin E, apoptosis malignant tumor