Serum Spondin-2 expression,tumor invasion,and antitumor immune response in patients with cervical cancer
作者机构：Department of GynecologyMaternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina Department of SurgeryMaternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina Department of Women’s HealthMaternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2022年第10卷第36期
页 面：13304-13312页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cervical cancer Spondin-2 Invasion and infiltration Immune response Prognosis Malignant tumor
摘 要：BACKGROUND Cervical cancer is a gynecological malignancy common in middle-aged and older patients,with a high mortality ***-2 is an extracellular matrix protein that involved in innate and acquired immune ***,we investigated the relationship between serum Spondin-2 expression,tumor invasion and infiltration,and immune response in patients with cervical cancer and provided a theoretical basis for clinical *** To investigate the relationship between serum Spondin-2 expression and cervical cancer-related *** Overall,147 patients with cervical cancer who were admitted to our institution between January 2019 and August 2019 were assigned to the cervical cancer group,and 92 patients with benign uterine lesions and 86 healthy individuals were assigned to the benign and control groups,*** each group,serum Spondin-2 expression was measured,and the receiver operating characteristic(ROC)curve was *** with cervical cancer were classified into high or low Spondin-2 groups depending on the Spondin-2 threshold value used for diagnosing cervical ***’s clinical data were collected to compare the clinicopathologic characteristics,immune cytokine levels,and prognosis of patients with varying Spondin-2 expression *** The expression level of serum Spondin-2 was significantly higher in the cervical cancer group than in the benign and control groups(P0.05).According to the ROC curve,the cutoff value of Spondin-2 used in the diagnosis of cervical carcinoma was 25.68±7.11μg/*** proportion of patients with Federation of Gynecology and Obstetrics stage III,nerve invasion,vascular invasion,and lymph node metastasis was higher in the high Spondin-2 group than in the low Spondin-2 group(P0.05).Interleukin-5(IL-5)and IL-4 Levels were higher in the high Spondin-2 group than in the low Spondin-2 *** contrast,IL-2 and tumor necrosis factor-αlevels were lower in the high Spondin-2 group than in th
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